ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Май 31, 2025

Hydrogel scaffolds represent an attractive tool for tissue repair. However, targeted repair requires a specific shape and biological function design, most natural-protein-based hydrogel are predominantly confined to applications. Here, we developed versatile structural biomimetic natural protein platform through synergistic electrospinning, photopolymerization, metal-coordination strategies. By integrating methacrylated silk fibroin (SFMA) with acrylated bisphosphonates (AcBP), dynamically functionalizable matrix that enables (1) customizable control via tunable electrospinning collectors (2) on-demand customization metal-ion chelation. As proof of concept, demonstrate this platform's scenario-specific therapeutic efficacy: (i) Mg2+-functionalized membranes (S-LB-Mg) orchestrate angiogenic-osteogenic coupling in critical-sized calvarial defects, (ii) Ag+-integrated dressing (S-LB-Ag) enabling bacterial eradication nonantibiotic mechanism accelerating infected wound closure, (iii) Zn2+-loaded conduits (S-LB-Zn) drive macrophage M2 polarization enhance peripheral nerve regeneration. This naturally derived protein-based overcomes the potential side effects associated clinical bioactive factor/antibiotic composite scaffolds, offering simple solution regeneration diverse tissues cost-effective yet highly effective manner. Overall, our strategy provides alternative perspective constructing protein-derived microfibers functions shapes

Язык: Английский