Clinical Oral Investigations, Год журнала: 2020, Номер 24(4), С. 1465 - 1477
Опубликована: Янв. 15, 2020
Язык: Английский
Advanced Healthcare Materials, Год журнала: 2018, Номер 7(13)
Опубликована: Март 5, 2018
Abstract Graphene materials (GMs), such as graphene, graphene oxide (GO), reduced GO (rGO), and quantum dots (GQDs), are rapidly emerging a new class of broad‐spectrum antimicrobial agents. This report describes their state‐of‐the‐art potential future covering both fundamental aspects biomedical applications. First, the current understanding mechanisms GMs is illustrated, complex picture underlying structure–property–activity relationships sketched. Next, different modes utilization explained, which include use colloidal dispersions, surface coatings, photothermal/photodynamic therapy Due to practical relevance, examples where function synergistic agents or release platforms for metal ions and/or antibiotic drugs also discussed. Later, applicability in design wound dressings, infection‐protective antibiotic‐like formulations (“nanoantibiotics”) assessed. Notably, support our assessments, existing clinical applications conventional carbon evaluated. Finally, key hurdles field highlighted, several possible directions investigations proposed. We hope that roadmap provided here will encourage researchers tackle remaining challenges toward translation promising research findings help realize nanomedicine.
Язык: Английский
Процитировано
216
Acta Biomaterialia, Год журнала: 2021, Номер 124, С. 33 - 49
Опубликована: Янв. 14, 2021
Язык: Английский
Процитировано
127
Materials Horizons, Год журнала: 2022, Номер 9(5), С. 1387 - 1411
Опубликована: Янв. 1, 2022
Anatomically, the human tooth has structures both embedded within and forming part of exterior surface body. When a is lost, it often replaced by dental implant, to facilitate chewing food for esthetic purposes. For successful substitution lost tooth, hard tissue should be integrated into implant surface. The microtopography chemistry have been explored with aim enhancing osseointegration. Additionally, clinical success dependent on ensuring that barrier, comprising strong gingival attachment an abutment, does not allow infiltration oral bacteria bone-integrated Epithelial connective cells respond abutment surface, depending its characteristics materials from which made. In particular, biomechanics implant-abutment connection structure (i.e., interface between surfaces, screw mechanics assembly) are critical soft seal integration. Herein, we discuss importance these three interfaces: bone-implant, gingiva-abutment, implant-abutment.
Язык: Английский
Процитировано
43
Bioactive Materials, Год журнала: 2022, Номер 18, С. 178 - 198
Опубликована: Март 19, 2022
Язык: Английский
Процитировано
43
Advanced Healthcare Materials, Год журнала: 2023, Номер 12(11)
Опубликована: Янв. 3, 2023
Abstract A poor seal of the titanium implant–soft tissue interface provokes bacterial invasion, aggravates inflammation, and ultimately results in implant failure. To ensure long‐term success implants, lactoferrin‐derived amyloid is coated on surface to increase expression cell integrins hemidesmosomes, with goal promoting soft imparting antibacterial activity implants. The structures contain a large number amino carboxyl groups their surfaces, promote proliferation adhesion epithelial cells fibroblasts via PI3K/AKT pathway. coating also has strong positive charge possesses potent activities against Staphylococcus aureus Porphyromonas gingivalis . In rat immediate implantation model, amyloid‐coated implants form gingival junctional epithelium at transmucosal region that resembles natural teeth. This provides wall off infection. Taken together, dual‐function transparent promotes activity. These unique properties enable synthesized be used as potential biological coatings.
Язык: Английский
Процитировано
25
Bioactive Materials, Год журнала: 2024, Номер 40, С. 19 - 33
Опубликована: Июнь 3, 2024
Infection and poor tissue repair are the key causes of percutaneous implantation failure. However, there is a lack effective strategies to cope with due its high requirements sterilization, soft healing, osseointegration. In this work, l-arginine (L-Arg) was loaded onto sulfonated polyetheretherketone (PEEK) surface solve issue. Under infection condition, nitric oxide (NO) reactive oxygen species (ROS) produced through catalyzing L-Arg by inducible synthase (iNOS) thus play role in bacteria sterilization. catalyzed ornithine Arginase-1 (Arg-1), which promotes proliferation collagen secretion L929 rBMSCs. Notably, loading samples could polarize macrophages M1 M2 conditions, respectively. The results
Язык: Английский
Процитировано
11
Journal of Materials Chemistry B, Год журнала: 2019, Номер 7(12), С. 2019 - 2031
Опубликована: Янв. 1, 2019
A facile method to achieve a stable collagen coating on titanium alloy was put forward promote the integration between percutaneous implant and soft tissue.
Язык: Английский
Процитировано
58
Advanced Functional Materials, Год журнала: 2020, Номер 30(21)
Опубликована: Март 20, 2020
Abstract The difficulties associated with metal implants and soft tissue integration have significantly affected the applications of in soft‐tissue‐related areas. Prompted by close association between immune response, an immunomodulation‐based strategy is proposed to manipulate microenvironment improve implant–soft integration. Considering their vital roles responses implants, macrophages are used cytokines fingerprints M1 M2 macrophage microenvironments evaluated for potential modulatory effects on different model cells (human gingival epithelium cells) cultured (titanium alloy disks) then described, underlying possible mechanism FAK‐AKT‐mTOR signaling unveiled. As further proof concept, IL‐4/PDA (polydopamine)‐coated titanium aiming at modulating polarization, prepared found vivo implant‐soft It authors' ambition that this will change negative perception encourage active development materials favorable properties, thus improving success rates perforating broadening application
Язык: Английский
Процитировано
58
Journal of Prosthodontic Research, Год журнала: 2020, Номер 65(1), С. 11 - 18
Опубликована: Сен. 8, 2020
Purpose: The concept of biological width has been proposed and widely used in oral implantation. This review aimed to summarize the around implant detail. Study selection: An electronic search literature prior March 2019 was performed identify all articles related periimplant soft tissue. conducted MEDLINE (National Library Medicine) database accessed through PubMed with no date restriction. following main keywords were used: "implant", "biological width", "soft tissue", "junctional epithelium", "peri-implant "connective "gingiva", "mucosa" (connecting multiple AND, OR). Results: identified researches focused on several aspects implantation, namely concept, formation, remodeling, dimension, structure function. Conclusions: Based reviewed literature, structure, functional significances are explored this narrative review. formation is a complex process after weeks healing. 3-4mm distance from top peri-implant mucosa first bone-to-implant contact or stabilized adjacent bone, consisting sulcular epithelium, junctional epithelium fibrous connective tissue between bone. forms barrier against bacteria, influences remodeling hard implications for clinical dental
Язык: Английский
Процитировано
56
Acta Biomaterialia, Год журнала: 2022, Номер 157, С. 108 - 123
Опубликована: Ноя. 24, 2022
Язык: Английский
Процитировано
37