Abstract
Immunotherapy
has
recently
emerged
as
a
promising
therapeutic
modality
for
the
treatment
of
various
diseases
such
cancer,
inflammation,
autoimmune
diseases,
and
infectious
diseases.
Despite
its
potential,
immunotherapy
faces
challenges
related
to
delivery
efficiency
off‐target
toxicity
immunotherapeutic
drugs.
Nano
drug
systems
offer
improvements
in
biodistribution
release
kinetics
but
still
suffer
from
shortcomings
high
immunogenicity,
poor
penetration
across
biological
barriers,
insufficient
tissue
permeability.
Targeted
drugs
using
living
cells
become
an
emerging
strategy
that
can
take
advantage
inherent
characteristics
deal
with
defects
nano
systems.
Furthermore,
themselves
be
genetically
engineered
into
cellular
enhanced
immunotherapy.
This
review
provides
in‐depth
exploration
cell‐derived
carriers,
detailing
their
properties,
functions,
commonly
used
loading
strategies.
In
addition,
role
modified
synergistic
effects
are
also
introduced.
By
summarizing
main
advancements
limitations
field,
this
offers
insights
potential
cell‐based
address
existing
The
introduction
recent
developments
evaluation
ongoing
research
will
pave
way
optimization
widespread
adoption
nano/genetically
ACS Nano,
Год журнала:
2019,
Номер
13(6), С. 6151 - 6169
Опубликована: Май 24, 2019
Layer-by-layer
(LbL)
assembly
is
a
widely
used
tool
for
engineering
materials
and
coatings.
In
this
Perspective,
dedicated
to
the
memory
of
ACS
Nano
associate
editor
Prof.
Dr.
Helmuth
Möhwald,
we
discuss
developments
applications
that
are
come
in
LbL
assembly,
focusing
on
coatings,
bulk
materials,
membranes,
nanocomposites,
delivery
vehicles.
Advanced Therapeutics,
Год журнала:
2018,
Номер
2(1)
Опубликована: Окт. 10, 2018
Abstract
Recent
advances
in
the
versatility
and
sophistication
of
design,
fabrication,
control
methods
mobile
microrobots
could
have
a
transforming
impact
on
future
healthcare
technologies.
Self‐propelled
or
remotely
actuated,
synthetic,
biohybrid
can
navigate
to
difficult‐to‐reach
regions
human
body
deliver
therapeutics
for
microscopically
localized
medical
interventions.
Here,
recent
progress
design
microrobotic
systems
concerning
therapeutic
delivery
drugs,
cells,
genetic
materials
is
reported.
This
perspective
prioritizes
aspects
cargo
loading,
navigation
biologically
relevant
environments,
controlled
release.
In
final
section,
prospects
discussion
critical
shortcomings
benchside‐to‐bedside
translation
are
provided.
ACS Nano,
Год журнала:
2018,
Номер
12(5), С. 4877 - 4885
Опубликована: Май 7, 2018
We
report
the
construction
of
erythrocyte
membrane-cloaked
Janus
polymeric
motors
(EM-JPMs)
which
are
propelled
by
near-infrared
(NIR)
laser
irradiation
and
successfully
applied
in
thrombus
ablation.
Chitosan
(a
natural
polysaccharide
with
positive
charge,
CHI)
heparin
(glycosaminoglycan
negative
Hep)
were
selected
as
wall
materials
to
construct
biodegradable
biocompatible
capsules
through
layer-by-layer
self-assembly
technique.
By
partially
coating
capsule
a
gold
(Au)
layer
sputter
coating,
NIR-responsive
structure
was
obtained.
Due
asymmetric
distribution
Au,
local
thermal
gradient
generated
upon
NIR
irradiation,
resulting
movement
JPMs
self-thermophoresis
effect.
The
reversible
"on/off"
motion
their
motile
behavior
easily
tuned
incident
intensity.
After
biointerfacing
an
membrane,
EM-JPMs
displayed
red
blood
cell
related
properties,
enabled
them
move
efficiently
relevant
biological
environments
(cell
culture,
serum,
blood).
Furthermore,
this
therapeutic
platform
exhibited
excellent
performance
ablation
photothermal
therapy.
As
man-made
micromotors,
these
biohybrid
hold
great
promise
navigating
vivo
for
active
delivery
while
overcoming
drawbacks
existing
synthetic
platforms.
expect
that
motor
has
considerable
potential
be
widely
used
biomedical
field.
Advanced Materials,
Год журнала:
2019,
Номер
32(13)
Опубликована: Июнь 28, 2019
Abstract
Breakthroughs
in
materials
engineering
have
accelerated
the
progress
of
immunotherapy
preclinical
studies.
The
interplay
chemistry
and
has
resulted
improved
loading,
targeting,
release
immunomodulatory
agents.
An
overview
that
are
used
to
enable
or
improve
success
immunotherapies
studies
is
presented,
from
immunosuppressive
proinflammatory
strategies,
with
particular
emphasis
on
technologies
poised
for
clinical
translation.
organized
based
their
characteristic
length
scale,
whereby
enabling
feature
each
technology
by
structure
material.
For
example,
mechanisms
which
i)
nanoscale
can
targeting
infiltration
payloads
into
tissues
cells,
ii)
microscale
facilitate
cell‐mediated
transport
serve
as
artificial
antigen‐presenting
iii)
macroscale
form
basis
microenvironments
promote
cell
reprogramming
discussed.
As
a
step
toward
establishing
set
design
rules
future
immunotherapies,
intrinsically
activate
suppress
immune
system
reviewed.
Finally,
brief
outlook
trajectory
these
systems
how
they
may
be
address
unsolved
challenges
cancer,
infectious
diseases,
autoimmunity
presented.
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2019,
Номер
15(4), С. 416 - 448
Опубликована: Сен. 26, 2019
Conventional
tumor-targeted
drug
delivery
systems
(DDSs)
face
challenges,
such
as
unsatisfied
systemic
circulation,
low
targeting
efficiency,
poor
tumoral
penetration,
and
uncontrolled
release.
Recently,
tumor
cellular
molecules-triggered
DDSs
have
aroused
great
interests
in
addressing
dilemmas.
With
the
introduction
of
several
additional
functionalities,
properties
these
smart
including
size,
surface
charge
ligand
exposure
can
response
to
different
microenvironments
for
a
more
efficient
targeting,
eventually
achieve
desired
release
an
optimized
therapeutic
efficiency.
This
review
highlights
recent
research
progresses
on
environment
responsive
targeted
delivery.
Dynamic
strategies
functional
moieties
sensitive
variety
stimuli,
pH,
glutathione,
adenosine-triphosphate,
reactive
oxygen
species,
enzyme
inflammatory
factors
are
summarized.
Special
emphasis
this
is
placed
their
mechanisms,
loading
models,
drawbacks
merits.
Several
typical
multi-stimuli
listed.
And
main
challenges
potential
future
development
discussed.
Immunotherapy
strategies
that
use
cell-based
delivery
systems
have
sparked
much
interest
in
the
treatment
of
malignancies,
owing
to
their
high
biocompatibility,
excellent
tumor
targeting
capability,
and
unique
biofunctionalities
growth
process.
A
variety
design
principles
for
immunotherapy,
including
cell
surface
decoration,
membrane
coating,
encapsulation,
genetically
engineered
cell,
cell-derived
exosomes,
give
cancer
immunotherapy
great
potential
improve
therapeutic
efficacy
reduce
adverse
effects.
However,
methods
is
still
limited,
practical
uses
are
hampered
due
complex
physiological
immunological
obstacles,
such
as
physical
barriers
immune
infiltration,
immunosuppressive
microenvironment,
upregulation
pathways,
metabolic
restriction.
In
this
review,
we
present
an
overview
maximize
impact,
along
with
anatomical,
metabolic,
impediments
using
treat
cancer.
Following
that,
a
summary
novel
been
created
overcome
these
obstacles
immunotherapeutic
provided.
Also,
prospects
next-step
development
concluded
end.
Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Сен. 15, 2022
Besides
the
broad
development
of
nanotechnological
approaches
for
cancer
diagnosis
and
therapy,
currently,
there
is
no
significant
progress
in
treatment
different
types
brain
tumors.
Therapeutic
molecules
crossing
blood-brain
barrier
(BBB)
reaching
an
appropriate
targeting
ability
remain
key
challenges.
Many
invasive
non-invasive
methods,
various
nanocarriers
their
hybrids
have
been
widely
explored
tumor
treatment.
However,
unfortunately,
crucial
clinical
translations
were
observed
to
date.
In
particular,
chemotherapy
surgery
main
methods
therapy
Exploring
mechanisms
BBB
penetration
detail
investigating
advanced
drug
delivery
platforms
are
factors
that
could
bring
us
closer
understanding
effective
against
this
review,
we
discuss
most
relevant
aspects
mechanisms,
observing
both
delivery.
We
also
review
recent
functional
platforms,
from
viruses
cell-based
vehicles,
therapy.
The
destructive
potential
chemotherapeutic
drugs
delivered
considered.
This
then
summarizes
existing
challenges
future
prospects
use
