Review on Silver Nanoparticles as a Novel Class of Antibacterial Solutions

Applied Sciences, Год журнала: 2021, Номер 11(3), С. 1120 - 1120

Опубликована: Янв. 26, 2021

Nanomaterials represent a promising novel class of materials to be used as antibacterial solutions. Inhomogeneity synthesis and characterization methods, well resulting variate physical chemical properties make selection proper nanostructure difficult when designing antimicrobial experiments. Present study focuses on the already existing evidence regarding silver nanoparticles their applications, with focus various modulatory factors reported efficiency. paper modulating efficiency, laboratory quantification procedures, up–to-date knowledge mechanisms action for nanoparticles. Moreover, challenges future prospects applications are reviewed discussed.

Язык: Английский

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Nanotechnology as a Novel Approach in Combating Microbes Providing an Alternative to Antibiotics

Antibiotics, Год журнала: 2021, Номер 10(12), С. 1473 - 1473

Опубликована: Ноя. 30, 2021

The emergence of infectious diseases promises to be one the leading mortality factors in healthcare sector. Although several drugs are available on market, newly found microorganisms carrying multidrug resistance (MDR) against which existing cannot function effectively, giving rise escalated antibiotic dosage therapies and need develop novel drugs, require time, money, manpower. Thus, exploitation antimicrobials has led production MDR bacteria, their prevalence growth a major concern. Novel approaches prevent antimicrobial drug practice. Nanotechnology-based innovation provides physicians patients opportunity overcome crisis resistance. Nanoparticles have promising potential Recently, nanoparticles been designed address pathogenic microorganisms. A multitude processes that can vary with various traits, including size, morphology, electrical charge, surface coatings, allow researchers composite substances for use different applications performing activities. activity inorganic carbon-based applied research, medical, industrial uses future offer solution traditional approaches. Metal-based also extensively studied many biomedical applications. In addition reduced size selectivity metal-based proven effective pathogens listed as priority, according World Health Organization (WHO). Moreover, studies were carried out not only vitro but vivo well order investigate efficacy. addition, nanomaterials provide numerous opportunities infection prevention, diagnosis, treatment, biofilm control. This study emphasizes effects contrasts nanoparticles’ antibiotics’ role fight Future prospects revolve around developing new strategies products prevent, control, treat microbial infections humans other animals, viral seen current pandemic scenarios.

Язык: Английский

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Recent Advances and Mechanistic Insights into Antibacterial Activity, Antibiofilm Activity, and Cytotoxicity of Silver Nanoparticles

ACS Applied Bio Materials, Год журнала: 2022, Номер 5(4), С. 1391 - 1463

Опубликована: Март 31, 2022

The substantial increase in multidrug-resistant (MDR) pathogenic bacteria is a major threat to global health. Recently, the Centers for Disease Control and Prevention reported possibilities of greater deaths due bacterial infections than cancer. Nanomaterials, especially small-sized (size ≤10 nm) silver nanoparticles (AgNPs), can be employed combat these deadly diseases. However, high reactivity, instability, susceptibility fast oxidation, cytotoxicity remain crucial shortcomings their uptake clinical application. In this review, we discuss various AgNPs-based approaches eradicate provide comprehensive mechanistic insights recent advances antibacterial activity, antibiofilm (both vitro vivo) AgNPs. antimicrobial activity involves four steps: (i) adhesion AgNPs cell wall/membrane its disruption; (ii) intracellular penetration damage; (iii) oxidative stress; (iv) modulation signal transduction pathways. Numerous factors affecting bactericidal such as shape, size, crystallinity, pH, surface coating/charge have also been described detail. review sheds light on photodynamic therapy role versus Ag+ ions release activities. addition, different methods synthesis discussed brief.

Язык: Английский

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Metal-based nanoparticles, sensors, and their multifaceted application in food packaging

Journal of Nanobiotechnology, Год журнала: 2021, Номер 19(1)

Опубликована: Авг. 26, 2021

Abstract Due to the global rise of human population, one top-most challenges for poor and developing nations is use food produces safely sustainably. In this regard, storage surplus (and derived products) without loss freshness, nutrient stability, shelf life, their parallel efficient utilization will surely boost production sector. One best technologies that have emerged within last twenty years with applications in packaging industrial materials green mode-based synthesized nanoparticles (NPs). These NPs are stable, advantageous as well eco-friendly. Over several years, numerous publications confirmed these exert antibacterial, antioxidant, antifungal activity against a plethora pathogens. The metal-based (M-NPs) does not hamper properties efficiency. Additionally, M-NPs help improvement including freshness indicators, mechanical properties, antibacterial water vapor permeability during packaging. As result, nano-technological application facilitates simple, alternate, interactive reliable technology. It even provides positive feedback industries markets. Taken together, current review paper an attempt highlight prominent antimicrobial nanosensors, items. some comparative reports associated mechanism action, risks, toxicity, overall future perspectives also been made.

Язык: Английский

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Engineering the drug carrier biointerface to overcome biological barriers to drug delivery

Advanced Drug Delivery Reviews, Год журнала: 2020, Номер 167, С. 89 - 108

Опубликована: Июнь 11, 2020

Язык: Английский

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