Molecular engineering of AIE-active boron clustoluminogens for enhanced boron neutron capture therapy

Chemical Science, Год журнала: 2024, Номер 15(11), С. 4019 - 4030

Опубликована: Янв. 1, 2024

This study presents a new type of boron carrier for neutron capture therapy that integrates imaging, lung cancer targeting drug and carborane, showcases an impressive therapeutic efficacy against tumors both in vitro vivo .

Язык: Английский

---

Modular Design of Peptide- or DNA-Modified AIEgen Probes for Biosensing Applications

Accounts of Chemical Research, Год журнала: 2019, Номер 52(11), С. 3064 - 3074

Опубликована: Окт. 28, 2019

ConspectusFluorophore probes are widely used for bioimaging in cells, tissues, and animals as well monitoring of multiple biological processes complex environments. Such imaging properties allow scientists to make direct visualizations pathological events cellular targets. Conventional fluorescent molecules have been developed several decades achieved great successes, but their emissions often weakened or quenched at high concentrations that might suffer from the aggregation-caused quenching (ACQ) effect, which reduces efficiencies applications.In contrast ACQ aggregation-induced emission (AIE) luminogens (AIEgens) display much higher fluorescence aggregated states possess various advantages such low background, long-term tracking ability, strong resistance photobleaching. Therefore, AIEgens employed unique building blocks biosensing applications fields ions, amino acids, carbohydrates, DNAs/RNAs, peptides/proteins, organelles, cancer bacteria, so on.Quite a few above missions accomplished by modular peptide-modified AIEgen (MPAPs) DNA-modified (MDAPs) because capabilities peptide DNA modules, including solubility, biocompatibility, recognition. Meanwhile, both electrostatic interactions coupling reactions could provide efficient methods construct different MPAPs MDAPs, finally resulting large variety probes. Those exhibit leading features detecting nucleic acids proteins mass biomolecules. For example, under design, modules possessing versatile recognition abilities enable detect numerous targets, integrin αvβ3, aminopeptidase N, MMP-2, MPO, H2O2, forth; MDAP mRNA cells tissue chips, suggesting diagnostic functions clinical samples. Modular design offers novel strategy generate AIEgen-based expedites functional biomacromolecules research. In this vein, here we review progress on MDAPs most recent 10 years highlight advanced briefly two aspects: (1) detection (2) imaging. By use MPAPs/MDAPs, bioanalytes can be efficiently analyzed directly visualized through high-contrast luminous Compared with MPAPs, quantities limited difficult synthesis long-length strands. future work, multifunctional sequences needed explore varieties diverse purposes. At end Account, some deficiencies challenges mentioned briging more attention accelerate development

Язык: Английский

---

AIE-based theranostic systems for detection and killing of pathogens

Theranostics, Год журнала: 2019, Номер 9(11), С. 3223 - 3248

Опубликована: Янв. 1, 2019

Pathogenic bacteria, fungi and viruses pose serious threats to the human health under appropriate conditions. There are many rapid sensitive approaches have been developed for identification quantification of specific pathogens, but challenges still exist. Culture/colony counting polymerase chain reaction classical methods used pathogen detection, their operations time-consuming laborious. On other hand, emergence spread multidrug-resistant pathogens is another global threat. It thus utmost urgency develop new therapeutic agents or strategies. Luminogens with aggregation-induced emission (AIEgens) derived supramolecular systems unique optical properties as fluorescent probes turn-on sensing high sensitivity specificity. In addition, AIE-based nanostructures exhibit excellent photodynamic inactivation (PDI) activity in aggregate, offering great potential not only light-up diagnosis pathogen, also image-guided PDI therapy pathogenic infection.

Язык: Английский

---

Endoplasmic reticulum targeted AIE bioprobe as a highly efficient inducer of immunogenic cell death

Science China Chemistry, Год журнала: 2020, Номер 63(10), С. 1428 - 1434

Опубликована: Авг. 27, 2020

Язык: Английский

---

Supramolecular Aggregation-Induced Emission Nanodots with Programmed Tumor Microenvironment Responsiveness for Image-Guided Orthotopic Pancreatic Cancer Therapy

ACS Nano, Год журнала: 2020, Номер 14(4), С. 5121 - 5134

Опубликована: Апрель 13, 2020

Supramolecular nanomaterials as drug carriers have recently received increasing attention due to their intrinsic merits such high stability, strong inclusion capability, and facile modification of the parental structure; however, intelligent ones with combined capacities long blood circulation, highly efficient tumor cell uptake, site-oriented release inside cells are still rather limited. Herein, we report a strategy using supramolecular aggregation-induced emission (AIE) nanodots for image-guided delivery, which integrate both advantages AIE nanomaterials. The dots prepared by host-guest coassembly matrix metalloproteinase-2 (MMP-2) sensitive PEG-peptide (PEG2000-RRRRRRRR (R8)-PLGLAG-EKEKEKEKEKEK (EK6)) functional α-cyclodextrins (α-CD) derivatives that conjugated anticancer gemcitabine (GEM) far-red/near-infrared fluorescent rhodanine-3-acetic acid-based luminogen, respectively. realize circulation time virtue zwitterionic stealth peptide EK6. After largely accumulating in tissues enhanced permeability retention effect, can successively respond tumor-overexpressed MMP-2 intracellular reductive microenvironment, achieving cancer cellular uptake selective GEM within cells, thus exhibit excellent inhibition ability subcutaneous orthotopic pancreatic models.

Язык: Английский

---