Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era

Acta Pharmaceutica Sinica B, Год журнала: 2021, Номер 11(9), С. 2609 - 2644

Опубликована: Июль 21, 2021

Membrane-disruptive peptides/peptidomimetics (MDPs) are antimicrobials or anticarcinogens that present a general killing mechanism through the physical disruption of cell membranes, in contrast to conventional chemotherapeutic drugs, which act on precise targets such as DNA specific enzymes. Owing their rapid action, broad-spectrum activity, and mechanisms action potentially hinder development resistance, MDPs have been increasingly considered future therapeutics drug-resistant era. Recently, growing experimental evidence has demonstrated can also be utilized adjuvants enhance therapeutic effects other agents. In this review, we evaluate literature around antimicrobial properties anticancer activity MDPs, summarize current alone combination with Notably, review highlights recent advances design various MDP-based drug delivery systems improve effect minimize side effects, promote co-delivery multiple chemotherapeutics, for more efficient therapy.

Язык: Английский

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Polymer-Based Coatings with Integrated Antifouling and Bactericidal Properties for Targeted Biomedical Applications

ACS Applied Polymer Materials, Год журнала: 2021, Номер 3(5), С. 2233 - 2263

Опубликована: Апрель 20, 2021

One of the most detrimental consequences surface colonization by bacteria is healthcare-associated infections (HAIs), which contribute to increased patient mortality and morbidity. Medical devices inserted into body provide a route for bacterial migration conducive surfaces their attachment proliferation. Antibacterial coatings can potentially minimize consequently reduce occurrence HAIs. function either inhibiting (antifouling coatings) or killing attached and/or in vicinity (bactericidal coatings). On an antifouling coating, any bacterium that manages attach will proliferate, while on bactericidal coatings, accumulation dead debris provides opportunities other colonize surface. As such, integration functionalities single coating combines advantages each, increasing probability be successfully inhibited. This Review highlights recent developments dual-functional polymer-based antibacterial specific biomedical applications. General strategies endowing with polymeric are first discussed, followed more detailed descriptions integrated target important applications: blood-contacting devices, orthopedic implants, wound dressings, ocular urinary catheters, endotracheal tubes, hospital textiles. The importance tailoring meet constraints requirements intended application beyond functionality emphasized, finally, potential challenges translating such clinical highlighted.

Язык: Английский

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Nanophysical Antimicrobial Strategies: A Rational Deployment of Nanomaterials and Physical Stimulations in Combating Bacterial Infections

Advanced Science, Год журнала: 2022, Номер 9(10)

Опубликована: Янв. 27, 2022

The emergence of bacterial resistance due to the evolution microbes under antibiotic selection pressure, and their ability form biofilm, has necessitated development alternative antimicrobial therapeutics. Physical stimulation, as a powerful method disrupt microbial structure, been widely used in food industrial sterilization. With advances nanotechnology, nanophysical strategies (NPAS) have provided unprecedented opportunities treat antibiotic-resistant infections, via combination nanomaterials physical stimulations. In this review, NPAS are categorized according modes which include mechanical, optical, magnetic, acoustic, electrical signals. biomedical applications combating infections systematically introduced, with focus on design mechanisms. Current challenges further perspectives clinical treatment also summarized discussed highlight potential use settings. authors hope that review will attract more researchers advance promising field NPAS, provide new insights for designing combat resistance.

Язык: Английский

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Recent progress in tannic acid-driven antibacterial/antifouling surface coating strategies

Journal of Materials Chemistry B, Год журнала: 2022, Номер 10(14), С. 2296 - 2315

Опубликована: Янв. 1, 2022

Tannic acid-based bioinspired coating strategies for tethering functional materials or molecules on different medical substrates resisting bacterial pathogens and fouling agents.

Язык: Английский

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Polysaccharide-based hydrogel with photothermal effect for accelerating wound healing

Carbohydrate Polymers, Год журнала: 2022, Номер 299, С. 120228 - 120228

Опубликована: Окт. 14, 2022

Язык: Английский

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