Materials & Design,
Год журнала:
2023,
Номер
226, С. 111604 - 111604
Опубликована: Янв. 6, 2023
The
main
limit
of
hydrogel
used
as
an
independent
wound
dressing
is
its
poor
water
retention,
brittleness,
and
weak
skin
adhesion.
Focusing
on
it,
the
macromolecular
cross-linked
chitosan
polyacrylamide
double
network
(C-A)
chosen
a
functional
layer,
another
robust
poly(vinyl
alcohol)-polyacrylamide/glycerin
(P-A)
protective
layer
designed
to
cover
surface,
interfacial
reaction
happens
link
two
layers
tightly
for
achieving
function
synergy.
In
this
double-layer
(DH)
dressing,
surface
P-A
with
strong
locking
ability
could
keep
moist
long
time,
high
strength
toughness
make
maintain
integrity
under
large
deformation
stress
strengthen
protection,
C-A
modest
adhesion
ensures
fit
skin,
synergistic
swelling
guarantee
fast
absorption
exudate.
Moreover,
in
vitro
vivo
tests,
DH
exhibits
excellent
antibacterial
cytocompatibility,
it
significantly
accelerate
tissue
regeneration
closure
than
commercial
hydrocolloid
dressings.
general,
easy
prepare
shows
superior
comprehensive
performance,
revealing
great
potential
use
independently
applied
dressing.
Materials & Design,
Год журнала:
2023,
Номер
229, С. 111917 - 111917
Опубликована: Апрель 7, 2023
Timely
and
accurate
assessment
of
wounds
during
the
wound
healing
process
is
key
for
correct
diagnosis
treatment
decisions
repair.
However,
traditional
management
strategies
often
fail
to
provide
timely
information
on
status,
thereby
delaying
or
misleading
treatments.
Smart
dressings
that
enable
in
situ
real-time
monitoring
wound-related
biomarkers,
early
on-demand
adverse
events,
such
as
bacterial
infection
inflammation,
by
integrating
wearable
sensors,
advanced
drug
delivery
systems
wireless
communication
technology
have
recently
been
developed
could
improve
management.
In
this
review,
we
provided
an
overview
including
temperature,
pH,
uric
acid,
glucose,
reactive
oxygen
(ROS),
enzymes,
related
events
exiting
sensors
detecting
these
biomarkers
based
colorimetric,
fluorimetric
electrochemical
approaches.
Examples
smart
integrate
controllable
functions
triggered
both
endogenous
exogenous
stimuli,
all-in-one
dressing
capable
treatment,
major
challenges
exciting
opportunities
are
presented
comprehensively
discussed.
Sensors and Actuators Reports,
Год журнала:
2022,
Номер
4, С. 100075 - 100075
Опубликована: Янв. 10, 2022
Wounds
especially
chronic
ones
significantly
affect
the
quality
of
patients'
life
and
present
a
severe
financial
burden
for
healthcare
industry.
Timely
effective
management
wounds,
such
as
diagnosing
wound
parameters,
treating
various
symptoms,
reducing
infection
at
noninvasively,
is
very
important
accelerating
healing
relieving
pain.
Recent
years
have
seen
significant
efforts
dedicated
to
developing
technologies
monitoring
biomarkers
vital
process
including
temperature,
pressure,
pH,
status
assist
with
diagnosis
treatment
well
advanced
therapies
on-demand
local
drug
delivery.
This
review
paper
introduces
recent
progress
on
multimodal
sensing
therapeutic
systems
healing.
Specifically,
we
focus
physical
(temperature,
moisture,
strain),
chemical
(pH,
uric
acid,
cytokine),
(active
delivery
based
external
stimulations
non-drug
stimulations).
In
addition,
leveraging
analytic
techniques,
i.e.,
machine
learning
deep
learning,
data-driven
assessment
has
been
discussed.
Materials & Design,
Год журнала:
2023,
Номер
226, С. 111604 - 111604
Опубликована: Янв. 6, 2023
The
main
limit
of
hydrogel
used
as
an
independent
wound
dressing
is
its
poor
water
retention,
brittleness,
and
weak
skin
adhesion.
Focusing
on
it,
the
macromolecular
cross-linked
chitosan
polyacrylamide
double
network
(C-A)
chosen
a
functional
layer,
another
robust
poly(vinyl
alcohol)-polyacrylamide/glycerin
(P-A)
protective
layer
designed
to
cover
surface,
interfacial
reaction
happens
link
two
layers
tightly
for
achieving
function
synergy.
In
this
double-layer
(DH)
dressing,
surface
P-A
with
strong
locking
ability
could
keep
moist
long
time,
high
strength
toughness
make
maintain
integrity
under
large
deformation
stress
strengthen
protection,
C-A
modest
adhesion
ensures
fit
skin,
synergistic
swelling
guarantee
fast
absorption
exudate.
Moreover,
in
vitro
vivo
tests,
DH
exhibits
excellent
antibacterial
cytocompatibility,
it
significantly
accelerate
tissue
regeneration
closure
than
commercial
hydrocolloid
dressings.
general,
easy
prepare
shows
superior
comprehensive
performance,
revealing
great
potential
use
independently
applied
dressing.
