Abstract
Nanoparticles
coated
with
natural
cell
membranes
have
emerged
as
a
promising
class
of
biomimetic
nanomedicine
significant
clinical
potential.
Among
them,
macrophage
membrane‐coated
nanoparticles
hold
particular
appeal
due
to
their
versatility
in
drug
delivery
and
biological
neutralization
applications.
This
study
employs
genetic
engineering
approach
enhance
vivo
residence
times,
aiming
further
improve
performance.
Specifically,
macrophages
are
engineered
express
proline‐alanine‐serine
(PAS)
peptide
chains,
which
provide
additional
protection
against
opsonization
phagocytosis.
The
resulting
modified
demonstrate
prolonged
times
when
administered
intravenously
or
introduced
intratracheally,
surpassing
those
the
wild‐type
membrane.
longer
also
contribute
enhanced
nanoparticle
efficacy
inhibiting
inflammatory
cytokines
mouse
models
lipopolysaccharide‐induced
lung
injury
sublethal
endotoxemia,
respectively.
underscores
effectiveness
modification
extending
nanoparticles.
can
be
readily
extended
modify
other
toward
more
favorable
biomedical
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101534 - 101534
Опубликована: Янв. 29, 2025
The
treatment
and
management
of
kidney
diseases
pose
a
significant
global
burden.
Due
to
the
presence
blood
circulation
barriers
glomerular
filtration
barriers,
drug
therapy
for
faces
challenges
such
as
poor
renal
targeting,
short
half-life,
severe
systemic
side
effects,
severely
hindering
therapeutic
progress.
Therefore,
research
development
kidney-targeted
agents
is
great
clinical
significance.
In
recent
years,
application
nanotechnology
in
field
nephrology
has
shown
potential
revolutionizing
diagnosis
diseases.
Carefully
designed
nanomaterials
can
exhibit
optimal
biological
characteristics,
influencing
various
aspects
circulation,
retention,
excretion.
Rationally
designing
modifying
based
on
anatomical
structure
pathophysiological
environment
achieve
highly
specific
or
nanodrug
delivery
systems
both
feasible
promising.
Based
targeted
diseases,
this
review
discusses
advantages
limitations
current
nanomedicine
summarizes
active/passive
targeting
strategies,
order
further
promote
through
preliminary
summary
previous
studies
future
prospects.
Bioactive Materials,
Год журнала:
2022,
Номер
23, С. 369 - 382
Опубликована: Ноя. 28, 2022
Acute
myocardial
infarction
(AMI)
induces
a
sterile
inflammatory
response,
leading
to
cardiomyocyte
damage
and
adverse
cardiac
remodeling.
Interleukin-5
(IL-5)
plays
an
essential
role
in
developing
eosinophils
(EOS),
which
are
beneficial
for
the
resolution
of
inflammation.
Furthermore,
proangiogenic
properties
IL-5
also
contribute
tissue
healing
following
injury.
Therefore,
targeted
delivery
is
innovative
therapeutic
approach
treating
AMI.
It
has
been
shown
that
conventional
can
result
undesirable
effects
potential
drug
overdose.
In
this
study,
we
successfully
synthesized
biomimetic
nanoparticle
by
camouflaging
neutrophilic
membrane.
The
administration
neutrophil
membrane-camouflaged
nanoparticles
(NM-NPIL-5)
vivo
model
showed
these
promoted
EOS
accumulation
angiogenesis
infarcted
myocardium,
thereby
limiting
remodeling
after
Our
results
demonstrated
NM-NPIL-5
could
serve
as
"decoys"
adsorb
neutralize
elevated
neutrophil-related
cytokines
injured
heart
inheriting
multiple
receptors
from
their
"parent"
neutrophils.
Finally,
protected
cardiomyocytes
excessive
inflammatory-induced
apoptosis
maintained
function.
findings
provided
promising
detoxification
agent
acute
Abstract
Nanoparticles
coated
with
natural
cell
membranes
have
emerged
as
a
promising
class
of
biomimetic
nanomedicine
significant
clinical
potential.
Among
them,
macrophage
membrane‐coated
nanoparticles
hold
particular
appeal
due
to
their
versatility
in
drug
delivery
and
biological
neutralization
applications.
This
study
employs
genetic
engineering
approach
enhance
vivo
residence
times,
aiming
further
improve
performance.
Specifically,
macrophages
are
engineered
express
proline‐alanine‐serine
(PAS)
peptide
chains,
which
provide
additional
protection
against
opsonization
phagocytosis.
The
resulting
modified
demonstrate
prolonged
times
when
administered
intravenously
or
introduced
intratracheally,
surpassing
those
the
wild‐type
membrane.
longer
also
contribute
enhanced
nanoparticle
efficacy
inhibiting
inflammatory
cytokines
mouse
models
lipopolysaccharide‐induced
lung
injury
sublethal
endotoxemia,
respectively.
underscores
effectiveness
modification
extending
nanoparticles.
can
be
readily
extended
modify
other
toward
more
favorable
biomedical
