Regenerative Therapy,
Год журнала:
2024,
Номер
26, С. 102 - 113
Опубликована: Май 29, 2024
Collagen,
a
naturally
occurring
fibrous
protein,
is
potential
resource
of
biological
materials
for
tissue
engineering
and
regenerative
medicine
because
it
structurally
biocompatible,
has
low
immunogenicity,
biodegradable,
biomimetic.
Numerous
studies
have
documented
in
the
literature
how
Collagen
nanofibers
exhibit
limited
cell
adhesion,
poor
viscosity,
no
interior
fibril
structure.
The
biomedical
industry
using
Poly
Glycerol
Sebacate
prepolymer(PGSp),
biodegradable
biocompatible
polyester
with
high
adhesion
very
viscous
appearance,
more
often.
Here,
unique
electrospun
Collagen/PGSp/ZnO/NPs
blend
skin
application
were
developed
described
varied
PGSp
percent.
Additionally,
when
ternary
blends
PGSp,
Zink
Oxide
Nanoparticles
(ZnO
NPs)
are
used,
antibacterial
properties
scaffolds
improved.
bead-free
produced
by
raising
concentration
to
30%w/w.
SEM,
EDS,
tensile,
MTT,
FTIR,
SDS-page,
swelling
test,
contact-angle,
antimicrobial,
biodegradation,
XRD,
attachment
procedures
used
characterize
crosslinked
nanofibers.
weight
ratio
Collagen/PGSp
30%/ZnONPs
1%
had
higher
stress/strain
strength
(0.25
mm/mm),
porosity
(563),
survival,
degradation
time.
Moreover,
after
applying
wound
healing
diabetic
rats,
30%/could
be
show
improving
significantly
compared
other
groups.
Journal of Orthopaedic Translation,
Год журнала:
2025,
Номер
50, С. 129 - 143
Опубликована: Янв. 1, 2025
At
present,
there
is
a
significant
population
of
individuals
experiencing
bone
deficiencies
caused
by
injuries,
ailments
affecting
the
bones,
congenital
abnormalities,
and
cancer.
The
management
substantial
defects
global
orthopedic
challenge
due
to
intricacies
involved
in
promoting
restoring
growth
fresh
osseous
tissue.
Autografts
are
widely
regarded
as
"gold
standard"
for
repairing
because
their
superior
tissue
acceptance
ability
control
osteogenesis.
However,
patients
undergoing
autografts
may
encounter
various
challenges,
including
but
not
limited
hernia,
bleeding,
nerve
impairment,
death.
Therefore,
researchers
regenerative
medicine
striving
find
alternatives.
Collagen
most
abundant
protein
human
body,
its
triple
helix
structure
gives
it
unique
characteristics
that
contribute
strength
functionality
tissues.
commonly
processed
into
forms
such
scaffolds,
sponges,
membranes,
hydrogels,
composite
materials,
compatibility
with
affinity
water,
minimal
potential
immune
reactions,
adaptability,
transport
nutrients
or
drugs.
As
an
alternative
material
field
regeneration,
collagen
becoming
increasingly
important.
objective
this
review
provide
comprehensive
analysis
primary
types
sources
collagen,
processes
synthesis
degradation,
well
advancements
made
regeneration
research
applications.
A
investigation
role
undertaken,
providing
valuable
points
reference
more
profound
comprehension
applications
field.
concluding
section
provides
overview
prospective
avenues
research,
underscoring
promising
future
highlighting
regeneration.
Translational
Potential
Article.
exploration
diverse
functions
translational
demonstrated
review,
these
findings
underscore
treatment
option
clinical
implications,
thus
paving
way
innovative
efficacious
therapeutic
strategies
domain.
Biomacromolecules,
Год журнала:
2023,
Номер
25(1), С. 5 - 23
Опубликована: Дек. 26, 2023
Proteins
can
self-assemble
into
a
range
of
nanostructures
as
result
molecular
interactions.
Amyloid
nanofibrils,
one
them,
were
first
discovered
with
regard
to
the
relevance
neurodegenerative
diseases
but
now
have
been
exploited
building
blocks
generate
multiscale
materials
designed
functions
for
versatile
applications.
This
review
interconnects
mechanism
amyloid
fibrillation,
current
approaches
synthesizing
protein-based
materials,
and
application
in
bioplastic
development.
We
focus
on
fundamental
structures
self-assembled
fibrils
how
external
factors
affect
protein
aggregation
optimize
process.
Protein
self-assembly
is
essentially
autonomous
congregation
smaller
units
larger,
organized
structures.
Since
properties
be
manipulated
by
changing
intrinsic
conditions,
serves
an
excellent
block
Building
these
principles,
general
processing
methods
pathways
from
raw
sources
mature
state
are
proposed,
providing
guide
development
large-scale
production.
Additionally,
this
discusses
diverse
nanofibrils
they
utilized
bioplastics.
The
economic
feasibility
bioplastics
also
compared
conventional
plastics
production
scenarios,
supporting
their
potential
sustainable
future
Abstract
The
concept
and
development
of
bone/cartilage
organoids
are
rapidly
gaining
momentum,
providing
opportunities
for
both
fundamental
translational
research
in
bone
biology.
Bone/cartilage
organoids,
essentially
miniature
tissues
grown
vitro,
enable
the
study
complex
cellular
interactions,
biological
processes,
disease
pathology
a
representative
controlled
environment.
This
review
provides
comprehensive
up-to-date
overview
field,
focusing
on
strategies
organoid
construction
strategies,
progresses
research,
potential
applications.
We
delve
into
significance
selecting
appropriate
cells,
matrix
gels,
cytokines/inducers,
techniques.
Moreover,
we
explore
role
advancing
our
understanding
reconstruction,
modeling,
drug
screening,
prevention,
treatment
strategies.
While
acknowledging
these
discuss
inherent
challenges
limitations
field
propose
solutions,
including
use
bioprinting
induction,
AI
improved
screening
exploration
assembloids
more
complex,
multicellular
models.
believe
that
with
continuous
refinement
standardization,
can
profoundly
impact
patient-specific
therapeutic
interventions
lead
way
regenerative
medicine.
