Soft and Flexible Bioelectronic Micro‐Systems for Electronically Controlled Drug Delivery
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 4, 2023
The
concept
of
targeted
and
controlled
drug
delivery,
which
directs
treatment
to
precise
anatomical
sites,
offers
benefits
such
as
fewer
side
effects,
reduced
toxicity,
optimized
dosages,
quicker
responses.
However,
challenges
remain
engineer
dependable
systems
materials
that
can
modulate
host
tissue
interactions
overcome
biological
barriers.
To
stay
aligned
with
advancements
in
healthcare
precision
medicine,
novel
approaches
are
imperative
improve
effectiveness,
biocompatibility,
compliance.
Electronically
delivery
(ECDD)
has
recently
emerged
a
promising
approach
calibrated
spatial
temporal
precision.
This
article
covers
recent
breakthroughs
soft,
flexible,
adaptable
bioelectronic
micro-systems
designed
for
ECDD.
It
overviews
the
most
widely
reported
operational
modes,
engineering
strategies,
electronic
interfaces,
characterization
techniques
associated
ECDD
systems.
Further,
it
delves
into
pivotal
applications
wearable,
ingestible,
implantable
medical
devices.
Finally,
discourse
extends
future
prospects
Язык: Английский
Printed Silk Microelectrode Arrays for Electrophysiological Recording and Controlled Drug Delivery
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(17)
Опубликована: Фев. 24, 2023
The
use
of
soft
and
flexible
bioelectronic
interfaces
can
enhance
the
quality
for
recording
cells'
electrical
activity
by
ensuring
a
continuous
intimate
contact
with
smooth,
curving
surfaces
found
in
physiological
environment.
This
work
develops
microelectrode
arrays
(MEAs)
made
silk
fibroin
(SF)
films
that
also
serve
as
drug
delivery
system.
Inkjet
printing
is
used
tool
to
deposit
substrate,
conductive
electrode,
insulator,
well
drug-delivery
nanocomposite
film.
approach
highly
versatile,
shown
fabrication
carbon
microelectrodes,
sandwiched
between
substrate
insulator.
technique
permits
development
thin-film
devices
be
employed
vitro
extracellular
recordings
HL-1
cell
action
potentials.
tuning
SF
applying
an
stimulus
produce
permeable
layer
on-demand
systems
demonstrated.
multifunctional
MEA
developed
here
pave
way
screening
time-resolved
localized
chemical
stimuli.
Язык: Английский
All Biodisintegratable Hydrogel Biohybrid Neural Interfaces with Synergistic Performances of Microelectrode Array Technologies, Tissue Scaffolding, and Cell Therapy
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(3)
Опубликована: Окт. 12, 2023
Abstract
Biohybrid
neural
interfaces
(BHNIs)
are
a
new
class
of
neuromodulating
devices
that
integrate
microelectrode
arrays
(MEAs)
and
cell
transplantation
to
improve
treatment
nerve
injuries
disorders.
However,
current
BHNI
made
from
abiotic
materials
usually
bio‐passive,
non‐biodisintegratable,
or
rigid,
which
restricts
encapsulated
activity
host
reconstruction
frequently
leads
local
tissue
inflammation.
Herein,
the
first
MEA
composed
all
disintegratable
hydrogel
scaffold
with
synergistic
performances
conformal
adhesiveness,
technologies,
scaffolding
stem
therapy
on
time
scale
appropriate
for
repair
is
proposed.
In
particular,
conductive
tracks
extracellular
matrix
(ECM)‐based
double‐cross‐linked
dual‐electrically
(ECH)
systems
robust
tissue‐mimicking
chemical/physical
properties,
electrical
conductivity,
an
affinity
progenitor
cells.
Meanwhile,
substrate
prepared
transglutaminase‐incorporated
gelatin/silk
precursors
simultaneously
promotes
gelation
interfacial
adhesion
between
stacks,
leading
rapid
scalable
device
integration.
When
full
subjected
various
mechanical
stimuli
moisture,
it
structurally
stable
low
impedance
(4
±
3
kΩ)
comparable
recently
reported
benchmark.
With
seamless
lamination
around
peripheral
fibers,
permits
successive
signal
monitoring
wound
condition
evaluation,
while
demonstrating
effects
spatiotemporally
controlled
stimulation
accelerate
restoration
motor
function.
This
completely
degraded
by
1
month
thus
eliminating
need
surgical
retrieval
stably
remain,
interact,
further
fuse
tissues,
successfully
exhibiting
compatible
integration
biology
implanted
system.
Язык: Английский
Bioprinting Soft 3D Models of Hematopoiesis using Natural Silk Fibroin‐Based Bioink Efficiently Supports Platelet Differentiation
Advanced Science,
Год журнала:
2024,
Номер
11(18)
Опубликована: Март 21, 2024
Abstract
Hematopoietic
stem
and
progenitor
cells
(HSPCs)
continuously
generate
platelets
throughout
one's
life.
Inherited
Platelet
Disorders
affect
≈
3
million
individuals
worldwide
are
characterized
by
defects
in
platelet
formation
or
function.
A
critical
challenge
the
identification
of
these
diseases
lies
absence
models
that
facilitate
study
hematopoiesis
ex
vivo.
Here,
a
silk
fibroin‐based
bioink
is
developed
designed
for
3D
bioprinting.
This
replicates
soft
biomimetic
environment,
enabling
controlled
differentiation
HSPCs
into
platelets.
The
formulation
consisting
fibroin,
gelatin,
alginate
fine‐tuned
to
obtain
viscoelastic,
shear‐thinning,
thixotropic
with
remarkable
ability
rapidly
recover
after
bioprinting
provide
structural
integrity
mechanical
stability
over
long‐term
culture.
Optical
transparency
allowed
high‐resolution
imaging
generation,
while
incorporation
enzymatic
sensors
quantitative
analysis
glycolytic
metabolism
during
represented
through
measurable
color
changes.
Bioprinting
patient
samples
revealed
decrease
metabolic
activity
production
Disorders.
These
discoveries
instrumental
establishing
reference
ranges
classification
automating
assessment
treatment
responses.
model
has
far‐reaching
implications
application
research
blood‐related
diseases,
prioritizing
drug
development
strategies,
tailoring
personalized
therapies.
Язык: Английский
Designing Silk Biomaterials toward Better Future Healthcare: The Development and Application of Silk‐Based Implantable Electronic Devices in Clinical Diagnosis and Therapy
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 17, 2024
Implantable
medical
electronic
devices
(IMEDs)
have
attracted
great
attention
and
shown
versatility
for
solving
clinical
problems
ranging
from
real-time
monitoring
of
physiological/
pathological
states
to
electrical
stimulation
therapy
brain
cell
activity
deep
stimulation.
The
ongoing
challenge
is
select
appropriate
materials
in
target
device
configuration
biomedical
applications.
Currently,
silk-based
biomaterials
been
developed
the
design
diagnostic
therapeutic
due
their
excellent
properties
abundant
active
sites
structure.
Herein,
aim
summarize
structural
characteristics,
physicochemical
properties,
bioactivities
natural
silk
as
well
derived
materials,
with
a
particular
focus
on
implantable
devices,
such
invasive
brain-computer
interfaces,
neural
recording,
vivo
electrostimulation.
In
addition,
future
opportunities
challenges
are
also
envisioned,
hoping
spark
interests
researchers
interdisciplinary
fields
biomaterials,
medicine,
electronics.
Язык: Английский
An Implantable and Degradable Silk Sericin Protein Film Energy Harvester for Next‐Generation Cardiovascular Electronic Devices
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 2, 2025
Abstract
Current
cardiovascular
implantable
electronic
devices
(CIEDs)
face
a
pressing
clinical
need
for
the
development
of
battery‐free,
biodegradable,
and
biocompatible
to
mitigate
risk
adverse
in
vivo
responses.
To
address
this
demand,
it
is
proposed
utilizing
natural
biomaterial,
silk
sericin
(SS),
which
exhibits
valuable
biological
activities
contains
abundant
asymmetric
amino
acids
with
adjustable
structures,
create
an
self‐powered
system
based
on
piezoelectric
principle.
The
functionalized
SS‐based
(F‐SS‐based)
film
demonstrates
high
longitudinal
tensor
(
d
33
)
12
pC
N
−1
.
An
energy‐generating
device
(EG
device)
can
generate
electric
energy
under
mechanical
force
both
vitro
vivo.
By
manually
tapping
EG‐device
few
minutes,
accumulated
electricity
commercial
capacitor
(1.1
µF)
could
illuminate
LEDs
or
operate
timer.
Furthermore,
instantaneous
power
density
(218.5
µW
m
−2
achieved
by
manual
EG
sufficient
deliver
effective
pacing
restart
non‐beating
heart
normalize
atrioventricular
block
preclinical
model.
Owing
its
biocompatibility
biodegradability
physiological
environments,
F‐SS‐based
holds
significant
promise
advancement
systems
next‐generation
CIEDs
other
degradable
devices.
Язык: Английский
Electro- and mechano-responsive vesicular carriers targeting tumors
Omar Khan,
Sumedh Bahadure,
Sri Pada Datta Chigurupati
и другие.
Elsevier eBooks,
Год журнала:
2025,
Номер
unknown, С. 283 - 315
Опубликована: Янв. 1, 2025
Язык: Английский
Printed Electronic Devices and Systems for Interfacing with Single Cells up to Organoids
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(20)
Опубликована: Дек. 13, 2023
Abstract
The
field
of
bioelectronics
with
the
aim
to
contact
cells,
cell
clusters,
biological
tissues
and
organoids
has
become
a
vast
enterprise.
Currently,
it
is
mainly
relying
on
classical
micro‐
nanofabrication
methods
build
devices
systems.
Very
recently
highly
pushed
by
development
novel
printable
organic,
inorganic
biomaterials
as
well
advanced
digital
printing
technologies
such
laser
inkjet
employed
in
this
endeavor.
Recent
advantages
alternative
additive
manufacturing
3D
enable
interesting
new
routes,
particular
for
applications
requiring
incorporation
delicate
or
creation
scaffold
structures
that
show
high
potential
building
hybrid
bio‐/inorganic
devices.
Here
current
state
printed
2D
electronic
related
lithography
techniques
interfacing
systems
are
reviewed.
focus
lies
vitro
single
cell,
organoids.
Challenges
future
prospects
discussed
all‐printed
bio/electronic
targeting
biomedical
research,
diagnostics,
health
monitoring.
Язык: Английский
Wetting Behavior of Inkjet-Printed Electronic Inks on Patterned Substrates
Langmuir,
Год журнала:
2024,
Номер
40(10), С. 5162 - 5173
Опубликована: Фев. 26, 2024
In
inkjet
printing
technology,
one
important
factor
influencing
the
quality
and
reliability
of
printed
films
is
interaction
jetted
ink
with
substrate
surface.
This
short-range
determines
wettability
adhesion
to
solid
surface
hence
responsible
for
final
shape
deposited
ink.
Here,
we
investigate
wetting
morphologies
inkjet-printed
inks
on
patterned
substrates
by
carefully
designed
experimental
test
structures
simulations.
The
contact
angles,
properties,
drop
shapes,
as
well
their
influence
device
variability,
are
experimentally
theoretically
analyzed.
For
simulations,
employ
phase-field
method,
which
based
free
energy
minimization
two-phase
system
given
boundary
conditions.
Through
a
systematic
investigation
drops
consisting
hydrophilic
hydrophobic
areas,
report
that
morphology
related
not
only
layout
volume
but
also
strategy
wettability.
Furthermore,
show
how
can
modify
intrinsic
enhance
reliability.
Based
present
findings,
cast
light
improvement
fabrication
thin
film
transistors.
Язык: Английский
Flexible Microelectrode Arrays Based on Vacuum Filling for Electrophysiology Sensing of Cardiomyocytes
Wangzihan Zhang,
Shanshan You,
Yike Zhou
и другие.
ACS Applied Electronic Materials,
Год журнала:
2024,
Номер
6(9), С. 6431 - 6439
Опубликована: Авг. 21, 2024
Microelectrode
arrays
(MEAs)
are
widely
used
platforms
for
the
electrophysiological
monitoring
of
cardiomyocytes,
providing
an
effective
method
to
enhance
efficiency
drug
development
and
analyze
disease
models.
However,
traditional
MEAs
fabricated
on
rigid
silicon
or
glass
substrates,
which
causes
a
huge
mismatch
modulus
with
myocardial
tissue.
In
this
work,
we
proposed
vacuum
filling
technology
bismuth–indium
(Bi–In)
alloy
flexible
MEA
fabrication.
The
was
realized
at
elevated
temperature
inside
polydimethylsiloxane
microchannels
when
Bi–In
in
its
liquid
state.
Then,
then
underwent
phase
transition
form
solid-state
electrodes
returned
room
temperature.
showed
good
flexibility,
could
resist
bending
(180°),
had
electrochemical
impedance
174.3
kΩ
1
kHz
electrode
diameter
is
50
μm.
devices
were
demonstrated
recording
signals
from
human-induced
pluripotent
stem
cell-derived
presented
excellent
biocompatibility,
able
detect
typical
field
potential
waveforms
amplitudes
>900
μV.
This
work
presents
approach
advancement
fabrication
serves
as
robust
tool
application
preclinical
analysis.
Язык: Английский