Bioengineering,
Год журнала:
2024,
Номер
11(2), С. 158 - 158
Опубликована: Фев. 5, 2024
Tendon
injuries
in
military
servicemembers
are
one
of
the
most
commonly
treated
nonbattle
musculoskeletal
(NBMSKIs).
Commonly
result
demanding
physical
training,
repetitive
loading,
and
frequent
exposures
to
austere
conditions,
tendon
represent
a
conspicuous
threat
operational
readiness.
healing
involves
complex
sequence
between
stages
inflammation,
proliferation,
remodeling
cycles,
but
regenerated
tissue
can
be
biomechanically
inferior
native
tendon.
Chemical
mechanical
signaling
pathways
aid
by
employing
growth
factors,
cytokines,
inflammatory
responses.
Exosome-based
therapy,
particularly
using
adipose-derived
stem
cells
(ASCs),
offers
prominent
cell-free
treatment,
promoting
repair
altering
mRNA
expression.
However,
each
these
approaches
is
not
without
limitations.
Future
advances
engineering
involving
magnetic
stimulation
gene
therapy
offer
non-invasive,
targeted
for
improved
engineering.
Ongoing
research
aims
translate
therapies
into
effective
clinical
solutions
capable
maximizing
readiness
warfighter
lethality.
Microstructures,
Год журнала:
2024,
Номер
4(2), С. 2024014 - 2024014
Опубликована: Янв. 1, 2024
Repairing
tissue
defects
caused
by
diseases
and
traumas
presents
significant
challenges
in
the
clinic.
Recent
advancements
biomaterials
have
offered
promising
strategies
for
promoting
regeneration.
In
particular,
exploration
of
3D
macro
microstructures
has
proven
crucial
this
process.
The
integration
macro,
micro,
nanostructures
facilitates
performance
terms
their
mechanical
properties,
degradation
rate,
distinctive
impacts
on
cellular
activities.
review,
we
summarize
recent
progress
with
hierarchical
structures
We
explore
various
methods
employed
designing
different
dimensions.
improvement
physicochemical
properties
bioactivities
hierarchically
structured
biomaterials,
including
regulation
degradability,
specific
functions
cell
behaviors,
been
highlighted.
Furthermore,
current
applications
regeneration
are
discussed.
Finally,
conclude
summarizing
developments
provide
future
perspectives.
Inorganics,
Год журнала:
2024,
Номер
12(11), С. 292 - 292
Опубликована: Ноя. 11, 2024
Regenerative
medicine
amalgamates
stem
cell
technology
and
tissue
engineering
strategies
to
replace
tissues
organs
damaged
by
injury,
aging,
ailment,
and/or
chronic
conditions
leveraging
the
innate
self-healing
mechanism
of
body.
The
term
‘regenerative
medicine’
was
coined
William
A.
Haseltine
during
a
1999
conference
on
Lake
Como.
Since
its
inception
in
1968,
field
has
offered
clinical
benefits
for
regeneration,
repair,
restoration
bones,
skin,
cartilage,
neural
tissue,
heart,
as
well
scaffold
fabrication.
regenerative
can
vastly
benefit
from
advancements
nanoscience
technology,
particularly
fabrication
application
inorganic-based
nanoparticles
bionanomaterials.
Due
tunable
intrinsic
properties,
i.e.,
size,
topography,
surface
charge,
chemical
stability,
biomaterials
have
surpassed
traditional
synthetic
materials.
Given
wide
gamut
near-future
applications
inorganic
biomaterials,
this
article
gives
an
overview
emerging
roles
research,
engineering,
artificial
skin
cartilage
nerve
injuries,
3D
bioprinting,
development
new
bio-scaffolds.
review
also
addresses
challenges
related
compatibility
utilizing
current
state-of-the-art
techniques.
Frontiers in Chemistry,
Год журнала:
2024,
Номер
12
Опубликована: Ноя. 20, 2024
The
extensive
utilization
of
natural
polymers
in
tissue
engineering
is
attributed
to
their
excellent
biocompatibility,
degradability,
and
resemblance
the
extracellular
matrix.
These
have
a
wide
range
applications
such
as
delivering
therapeutic
medicine,
detecting
diseases,
sensing
biological
substances,
promoting
regeneration,
treating
diseases.
This
brief
review
current
developments
properties
uses
widely
used
biomedical
derived
from
nature.
Additionally,
it
explores
correlation
between
characteristics
functions
these
materials
different
highlights
prospective
direction
for
advancement
polymer
engineering.
Bioengineering,
Год журнала:
2024,
Номер
11(2), С. 158 - 158
Опубликована: Фев. 5, 2024
Tendon
injuries
in
military
servicemembers
are
one
of
the
most
commonly
treated
nonbattle
musculoskeletal
(NBMSKIs).
Commonly
result
demanding
physical
training,
repetitive
loading,
and
frequent
exposures
to
austere
conditions,
tendon
represent
a
conspicuous
threat
operational
readiness.
healing
involves
complex
sequence
between
stages
inflammation,
proliferation,
remodeling
cycles,
but
regenerated
tissue
can
be
biomechanically
inferior
native
tendon.
Chemical
mechanical
signaling
pathways
aid
by
employing
growth
factors,
cytokines,
inflammatory
responses.
Exosome-based
therapy,
particularly
using
adipose-derived
stem
cells
(ASCs),
offers
prominent
cell-free
treatment,
promoting
repair
altering
mRNA
expression.
However,
each
these
approaches
is
not
without
limitations.
Future
advances
engineering
involving
magnetic
stimulation
gene
therapy
offer
non-invasive,
targeted
for
improved
engineering.
Ongoing
research
aims
translate
therapies
into
effective
clinical
solutions
capable
maximizing
readiness
warfighter
lethality.
