Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(13)
Опубликована: Фев. 9, 2024
Aggregation-induced
emission
luminogens
(AIEgens)
are
promising
photosensitizers
that
have
exhibited
excellent
antibacterial
ability
with
abundant
reactive
oxygen
species
(ROS)
generation.
TTCPy-PF6
and
TTCPy-Br
deposited
on
the
surface
of
diverse
solid
substrates
through
plasma-assistant
electrostatic
self-assembly.
The
AIEgens-covered
coating
can
effectively
eliminate
different
pathogenic
Gram-positive
(G+)
bacteria
even
their
multidrug-resistant
(MDR)
mutants
negligible
side
effects
such
as
cytotoxicity,
hemolysis,
inflammation.
Moreover,
AIEgen-coated
maintain
high
stability
for
long-time
usage,
which
is
dependent
ROS-mediated
disruption
attached
bacteria.
AIEgen-based
coatings
broad
applicability
many
advantages
in
ability,
great
biocompatibility,
low
possibility
antibiotic
pollution.
robust
biological
safety
would
be
helpful
disinfection
medical
devices.
Abstract
Microbial
infections
based
on
drug‐resistant
pathogenic
organisms
following
surgery
or
trauma
and
uncontrolled
bleeding
are
the
main
causes
of
increased
mortality
from
worldwide.
The
prevalence
pathogens
has
led
to
a
significant
increase
in
medical
costs
poses
great
threat
normal
life
people.
This
is
an
important
issue
field
biomedicine,
emergence
new
antimicrobial
materials
hydrogels
holds
promise
for
solving
this
problem.
Hydrogel
material
with
good
biocompatibility,
water
absorption,
oxygen
permeability,
adhesion,
degradation,
self‐healing,
corrosion
resistance,
controlled
release
drugs
as
well
structural
diversity.
Bacteria‐disturbing
have
applications
direction
surgical
treatment,
wound
dressing,
device
coating,
tissue
engineering.
paper
reviews
classification
hydrogels,
current
status
research,
potential
one
application
analyzes
research
biomedical
five
aspects:
metal‐loaded
drug‐loaded
carbon‐material‐loaded
fixed
activity
biological
provides
outlook
high
activity,
biodegradability,
injectability,
clinical
applicability
future
development
prospects
field.
Chemical Engineering Journal,
Год журнала:
2024,
Номер
487, С. 150403 - 150403
Опубликована: Март 16, 2024
Hydrogels
have
emerged
in
various
biomedical
applications,
including
tissue
engineering
and
medical
devices,
due
to
their
ability
imitate
the
natural
extracellular
matrix
(ECM)
of
tissues.
However,
conventional
static
hydrogels
lack
dynamically
respond
changes
surroundings
withstand
robust
biophysical
microenvironment
trigger
on-demand
functionality
such
as
drug
release
mechanical
change.
In
contrast,
multifunctional
dynamic
can
adapt
external
stimuli
drawn
great
attention
recent
studies.
It
is
realized
that
integration
nanomaterials
into
provides
numerous
functionalities
for
a
variety
applications
cannot
be
achieved
by
hydrogels.
This
review
article
comprehensive
overview
advances
designing
fabricating
applications.
We
describe
different
types
based
on
breakable
reversible
covalent
bonds
well
noncovalent
interactions.
These
mechanisms
are
described
detail
useful
reference
crosslinking
strategies
strongly
influence
properties
also
discuss
use
potential
benefits.
further
explores
nanocomposite
hydrogels,
delivery,
engineering,
bioadhesives,
wound
healing,
cancer
treatment,
mechanistic
study,
multiple-scale
Finally,
we
challenges
future
perspectives
field
diverse
technologies.
Progress in Polymer Science,
Год журнала:
2024,
Номер
150, С. 101792 - 101792
Опубликована: Янв. 26, 2024
In
the
last
decades,
adhesives
derived
from
natural
resources
(i.e.,
bioadhesives)
have
emerged
as
promising
alternative
to
standard
wound
closure
devices,
including
sutures,
clips,
and
strips,
owing
relatively
easy
rapid
application,
minimal
tissue
damage,
fast
hemostasis,
ability
decrease
risk
of
infection.
Various
synthetic
materials
been
utilized
bioadhesives.
These
find
extensive
application
in
various
biomedical
fields,
ranging
simple
sealing
controlled
drug
delivery,
regeneration,
noninvasive
therapy.
Considering
weak
underwater
adhesion,
degradability,
biological
performances
adhesives,
naturally
derived-based
are
more
attractive.
The
first
generation
these
bioadhesives
provided
primarily
only
one
function.
Moreover,
they
had
issues
long
curing
time,
slow
high
degradation
rate,
low
mechanical
properties,
transferring
contamination
wound.
chemically
genetically
engineered
strategies
applied
advance
their
multifunctionality.
synergy
bonding
chemistry,
topography,
mechanics
dissipation
structure
supports
improved
adhesion
rate.
developed
that
cover
subjects
innovative
biomaterial
synthesis
or
functionalization
cutting-edge
manufacturing
processes.
However,
fulfill
all
criteria
an
ideal
bioadhesive
for
clinical
applications,
efforts
should
be
devoted
investigating
surface
characteristics
target
tissues
long-term
relationship
between
physiochemical
properties
polymers
cohesion
mechanisms,
well
adhesive
functionality.
This
review
outlines
recent
progress
on
naturally-derived
bioadhesives,
proteins
polysaccharides,
focusing
designing
approaches
based
engineering
strategies,
development,
applications.
Furthermore,
challenges
current
studies
summarized
show
future
perspectives
developing
bioengineered
high-performance
use.
Advanced Materials,
Год журнала:
2023,
Номер
35(49)
Опубликована: Июнь 3, 2023
Bioadhesives
with
antimicrobial
properties
enable
easier
and
safer
treatment
of
wounds
as
compared
to
the
traditional
methods
such
suturing
stapling.
Composed
natural
or
synthetic
polymers,
these
bioadhesives
seal
facilitate
healing
while
preventing
infections
through
activity
locally
released
drugs,
nanocomponents,
inherently
polers.
Although
many
different
materials
strategies
are
employed
develop
bioadhesives,
design
biomaterials
necessitates
a
prudent
approach
achieving
all
required
including
optimal
adhesive
cohesive
properties,
biocompatibility,
can
be
challenging.
Designing
tunable
physical,
chemical,
biological
will
shed
light
on
path
for
future
advancement
properties.
In
this
review,
requirements
commonly
used
developing
discussed.
particular,
their
synthesis
experimental
clinical
applications
variety
organs
reviewed.
Advances
in
pave
way
better
management
increase
positive
outcomes.
