Journal of drug targeting,
Год журнала:
2024,
Номер
32(4), С. 365 - 380
Опубликована: Фев. 5, 2024
Various
cells
in
our
body
regularly
divide
to
replace
old
and
dead
cells.
For
a
living
cell
be
growing,
division
differentiation
is
highly
essential.
Cancer
characterised
by
uncontrollable
invasion
of
other
tissues
due
dysregulation
the
cycle.
An
accumulation
genetic
changes
or
mutations
develops
through
different
physical
(UV
radiations),
chemical
(chewing
smoking
tobacco,
pollutants/mutagens),
biological
(viruses)
hereditary
factors
that
can
lead
cancer.
Now,
cancer
considered
as
major
death-causing
factor
worldwide.
Due
advancements
technology,
treatment
like
chemotherapy,
radiation
therapy,
bone
marrow
transplant,
immunotherapy,
hormone
therapy
many
more
rows.
Although,
it
also
has
some
side
effects
fatigue,
hair
fall,
anaemia,
nausea
vomiting,
constipation.
Modern
improved
drug
therapies
come
with
severe
effects.
There
need
for
safer,
effective,
low-cost
lesser
side-effects.
Biologically
active
natural
products
derived
from
plants
are
emerging
strategy
deal
proliferation.
Moreover,
they
possess
anti-carcinogenic,
anti-proliferative
anti-mutagenic
properties
reduced
They
detoxify
remove
reactive
substances
formed
carcinogenic
agents.
In
this
article,
we
discuss
plant-based
their
mechanism
action
against
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
165, С. 115135 - 115135
Опубликована: Июль 13, 2023
Exosomes,
remarkable
extracellular
vesicles,
have
emerged
as
an
advanced
frontier
in
intercellular
communication.
This
capacity
positions
them
promising
contenders
drug
delivery
systems
(DDSs)
for
osteoarthritis
(OA)
therapy,
capitalizing
on
their
inherent
biocompatibility,
stability,
and
minimal
immunogenicity.
In
this
comprehensive
review,
we
summarize
the
emerging
developments
surrounding
exosome-based
DDSs
OA
therapy.
Focusing
exosome
origins,
meticulously
explore
diverse
sources
contributing
to
production,
including
invaluable
stem
cells,
immune
array
of
other
cell
types.
addition,
unravel
underlying
mechanisms
action
that
govern
these
exosome-borne
therapeutics,
illuminating
intricate
interplay
between
exosomes
recipient
cells.
summary,
review
highlights
present
challenges
permeate
Through
in-depth
exploration
intricacies
within
field,
aims
shed
light
future
direction
OA.
It
serves
a
bridge
fostering
collaboration
collective
efforts
reshaping
treatment
landscape
Virtual and Physical Prototyping,
Год журнала:
2024,
Номер
19(1)
Опубликована: Апрель 27, 2024
In
bone
tissue
engineering,
the
search
for
improved
repair
methods
is
crucial,
given
drawbacks
of
traditional
strategies
like
donor
site
issues
and
immune
rejection.
Addressing
these
challenges,
this
paper
introduces
an
innovative
GelMA/Bentonite
composite
bioink
3D
bioprinting,
designed
to
create
scaffolds
that
closely
emulate
native
tissue.
GelMA
selected
its
biocompatibility
modifiable
mechanics,
while
Bentonite's
mineral
richness
ion
exchange
capacity
are
harnessed
enhance
scaffold
structure
promote
osteogenic
microenvironment.
This
research
marks
inaugural
incorporation
Bentonite
into
a
bioink,
significant
stride
forward
established
safety
in
pharmaceuticals
versatility
across
industries.
formulation
signifies
breakthrough
aiming
improve
osteointegration
regeneration
Combining
with
key
step
creating
bioinks
healing,
potentially
transforming
scaffold-based
pioneering
use
natural
nanomaterials
medicine.
Healthy
aging
is
a
common
goal
for
humanity
and
society,
one
key
to
achieving
it
the
rejuvenation
of
senescent
resident
stem
cells
empowerment
organ
regeneration.
However,
mechanistic
understandings
cell
senescence
potential
strategies
counteract
remain
elusive.
Here,
we
reveal
that
bone
microenvironment
impairs
Golgi
apparatus
thus
diminishing
mesenchymal
(MSC)
function
Interestingly,
replenishment
aggregates-derived
extracellular
vesicles
(CA-EVs)
rescues
dysfunction
empowers
MSCs
through
regulatory
protein
Syntaxin
5.
Importantly,
in
vivo
administration
CA-EVs
significantly
enhanced
defect
repair
rate
improved
mass
mice,
suggesting
their
therapeutic
value
treating
age-related
osteoporosis
promoting
Collectively,
our
findings
provide
insights
into
regulation
aging,
which
further
highlight
as
rejuvenative
approach
Journal of drug targeting,
Год журнала:
2024,
Номер
32(4), С. 365 - 380
Опубликована: Фев. 5, 2024
Various
cells
in
our
body
regularly
divide
to
replace
old
and
dead
cells.
For
a
living
cell
be
growing,
division
differentiation
is
highly
essential.
Cancer
characterised
by
uncontrollable
invasion
of
other
tissues
due
dysregulation
the
cycle.
An
accumulation
genetic
changes
or
mutations
develops
through
different
physical
(UV
radiations),
chemical
(chewing
smoking
tobacco,
pollutants/mutagens),
biological
(viruses)
hereditary
factors
that
can
lead
cancer.
Now,
cancer
considered
as
major
death-causing
factor
worldwide.
Due
advancements
technology,
treatment
like
chemotherapy,
radiation
therapy,
bone
marrow
transplant,
immunotherapy,
hormone
therapy
many
more
rows.
Although,
it
also
has
some
side
effects
fatigue,
hair
fall,
anaemia,
nausea
vomiting,
constipation.
Modern
improved
drug
therapies
come
with
severe
effects.
There
need
for
safer,
effective,
low-cost
lesser
side-effects.
Biologically
active
natural
products
derived
from
plants
are
emerging
strategy
deal
proliferation.
Moreover,
they
possess
anti-carcinogenic,
anti-proliferative
anti-mutagenic
properties
reduced
They
detoxify
remove
reactive
substances
formed
carcinogenic
agents.
In
this
article,
we
discuss
plant-based
their
mechanism
action
against
