Exosomes derived from vMIP-II-Lamp2b gene-modified M2 cells provide neuroprotection by targeting the injured spinal cord, inhibiting chemokine signals and modulating microglia/macrophage polarization in mice

Experimental Neurology, Год журнала: 2024, Номер 377, С. 114784 - 114784

Опубликована: Апрель 19, 2024

Язык: Английский

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A multifunctional silk-hyaluronic acid self-healing hydrogel laden with alternatively activated macrophage-derived exosomes reshape microenvironment of diabetic wound and accelerate healing

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 270, С. 132384 - 132384

Опубликована: Май 14, 2024

Язык: Английский

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Engineering extracellular vesicles for diagnosis and therapy

Trends in Pharmacological Sciences, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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Exosome-based platforms for treatment of multiple sclerosis

Brain Research Bulletin, Год журнала: 2025, Номер 222, С. 111256 - 111256

Опубликована: Фев. 12, 2025

Multiple sclerosis (MS) is a chronic autoimmune illness characterized by inflammation and demyelination of the central nervous system (CNS). The effective delivery therapeutic agents to CNS continues be an important barrier in MS treatment due blood-brain limited access affected areas. Exosome-based drug systems have become attractive option for targeted therapy MS. Exosomes, small extracellular vesicles derived from various cell types, possess unique biological properties that make them ideal nanocarriers delivering cargo specific populations CNS. In this study, we supply comprehensive overview current advances future perspectives exosome-based We discuss biogenesis exosomes, strategies loading, engineering approaches enhance their targeting capabilities, potential clinical applications exosome-mediated therapy. Additionally, explore preclinical studies animal models demonstrate effectiveness ameliorating pathology. By highlighting challenges opportunities utilizing exosomes as vehicles, review aims contribute growing body knowledge field nanomedicine Considering accessibility, specificity, therapies while minimizing off-target effects might change scenario

Язык: Английский

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Engineered hybrid exosomes responsive to reactive oxygen species target the treatment of spinal cord injury by repairing mitochondrial damage and promoting neuronal function recovery

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160669 - 160669

Опубликована: Фев. 1, 2025

Язык: Английский

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