Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 21, 2023
Abstract
The
formulation
of
an
antibiotic-free
antibacterial
approach
is
imperative
in
circumventing
escalating
bacterial
drug
resistance.
Electrical
stimulation
presents
a
viable
therapeutic
modality
for
such
approach.
Nonetheless,
obstacles
persist
achieving
efficacious
sterilization
with
biosafe
low-voltage
electrical
fields
(EFs)
and
enduring
capabilities.
In
this
study,
we
have
devised
novel
capacitive
dressing
comprising
polypyrrole-wrapped
carbon
cloth
(PPy-CC)
electrodes
cellulose
(BC)
hydrogel
separator.
Subjected
to
1V
10
minutes,
the
attains
high
bactericidal
efficiency
(up
99.97%)
enhanced
activity
against
multidrug-resistant
(MDR)
bacteria
99.99%).
Its
considerable
electric
capacity
rechargeability
allow
repeated
charging
achieve
sustained
sterilization.
vivo
results
demonstrate
significant
inhibition
wound
infection
facilitated
recovery
infected
full-thickness
defects
mouse
models.
This
represents
antibiotic-free,
physically-stimulated
treatment
wounds
potential
clinical
application.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(23)
Опубликована: Янв. 7, 2024
Abstract
The
incidence
of
large
bone
and
articular
cartilage
defects
caused
by
traumatic
injury
is
increasing
worldwide;
the
tissue
regeneration
process
for
these
injuries
lengthy
due
to
limited
self‐healing
ability.
Endogenous
bioelectrical
phenomenon
has
been
well
recognized
play
an
important
role
in
homeostasis
regeneration.
Studies
have
reported
that
electrical
stimulation
(ES)
can
effectively
regulate
various
biological
processes
holds
promise
as
external
intervention
enhance
synthesis
extracellular
matrix,
thereby
accelerating
Hence,
electroactive
biomaterials
considered
a
biomimetic
approach
ensure
functional
recovery
integrating
physiological
signals,
including
electrical,
biochemical,
mechanical
signals.
This
review
will
discuss
endogenous
bioelectricity
tissue,
effects
ES
on
cellular
behaviors.
Then,
recent
advances
materials
their
applications
are
systematically
overviewed,
with
focus
advantages
disadvantages
repair
performances
modulation
cell
fate.
Finally,
significance
mimicking
electrophysiological
microenvironment
target
emphasized
future
development
challenges
strategies
proposed.
Journal of Orthopaedic Translation,
Год журнала:
2024,
Номер
47, С. 191 - 206
Опубликована: Июнь 27, 2024
The
regenerative
capacity
of
bone
is
indispensable
for
growth,
given
that
accidental
injury
almost
inevitable.
Bone
relevant
the
aging
population
globally
and
repair
large
defects
after
osteotomy
(e.g.,
following
removal
malignant
tumours).
Among
many
therapeutic
modalities
proposed
to
regeneration,
electrical
stimulation
has
attracted
significant
attention
owing
its
economic
convenience
exceptional
curative
effects,
various
electroactive
biomaterials
have
emerged.
This
review
summarizes
current
knowledge
progress
regarding
strategies
improving
repair.
Such
range
from
traditional
methods
delivering
via
electroconductive
materials
using
external
power
sources
self-powered
biomaterials,
such
as
piezoelectric
nanogenerators.
Electrical
osteogenesis
are
related
piezoelectricity.
examines
cell
behaviour
potential
mechanisms
electrostimulation
in
healing,
aiming
provide
new
insights
regeneration
biomaterials.
roles
rehabilitating
microenvironment
facilitate
addressing
whereby
cues
mediate
regeneration.
Interactions
between
osteogenesis-related
cells
summarized,
leading
proposals
use
stimulation-based
therapies
accelerate
healing.
Nano-Micro Letters,
Год журнала:
2024,
Номер
17(1)
Опубликована: Окт. 17, 2024
The
incidence
of
large
bone
defects
caused
by
traumatic
injury
is
increasing
worldwide,
and
the
tissue
regeneration
process
requires
a
long
recovery
time
due
to
limited
self-healing
capability.
Endogenous
bioelectrical
phenomena
have
been
well
recognized
as
critical
biophysical
factors
in
remodeling
regeneration.
Inspired
bioelectricity,
electrical
stimulation
has
widely
considered
an
external
intervention
induce
osteogenic
lineage
cells
enhance
synthesis
extracellular
matrix,
thereby
accelerating
With
ongoing
advances
biomaterials
energy-harvesting
techniques,
electroactive
self-powered
systems
biomimetic
approaches
ensure
functional
recapitulating
natural
electrophysiological
microenvironment
healthy
tissue.
In
this
review,
we
first
introduce
role
bioelectricity
endogenous
electric
field
summarize
different
techniques
electrically
stimulate
Next,
highlight
latest
progress
exploring
hybrid
such
triboelectric
piezoelectric-based
nanogenerators
photovoltaic
cell-based
devices
their
implementation
engineering.
Finally,
emphasize
significance
simulating
target
tissue's
propose
opportunities
challenges
faced
bioelectronics
for
repair
strategies.
Abstract
The
unique
ability
of
piezoelectric
materials
to
generate
electricity
spontaneously
has
attracted
widespread
interest
in
the
medical
field.
In
addition
convert
mechanical
stress
into
electrical
energy,
offer
advantages
high
sensitivity,
stability,
accuracy
and
low
power
consumption.
Because
these
characteristics,
they
are
widely
applied
devices
such
as
sensors,
controllers
actuators.
However,
also
show
great
potential
for
manufacturing
artificial
organs
tissue
regeneration
repair
applications.
For
example,
use
cochlear
implants,
cardiac
pacemakers
other
equipment
may
help
restore
body
function.
Moreover,
recent
studies
have
shown
that
signals
play
key
roles
promoting
regeneration.
this
context,
application
generated
by
processes
bone
healing,
nerve
skin
become
a
prospective
strategy.
By
mimicking
natural
bioelectrical
environment,
can
stimulate
cell
proliferation,
differentiation
connection,
thereby
accelerating
process
self-repair
body.
many
challenges
remain
be
overcome
before
concepts
clinical
practice,
including
material
selection,
biocompatibility
design.
On
basis
principle
signal
regulation,
article
reviews
definition,
mechanism
action,
classification,
preparation
current
biomedical
applications
discusses
opportunities
their
future
translation.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 22, 2025
Abstract
Despite
advancements
in
engineered
heart
tissue
(EHT),
challenges
persist
achieving
accurate
dimensional
accuracy
of
scaffolds
and
maturing
human
induced
pluripotent
stem
cell‐derived
cardiomyocytes
(hiPSC‐CMs),
a
primary
source
functional
cardiac
cells.
Drawing
inspiration
from
muscle
fiber
arrangement,
three‐dimensional
(3D)‐printed
multi‐layered
microporous
polycaprolactone
(PCL)
scaffold
is
created
with
interlayer
angles
set
at
45°
to
replicate
the
precise
structure
native
tissue.
Compared
control
group
90°
PCL
scaffolds,
exhibited
superior
biocompatibility
for
cell
culture
improved
hiPSC‐CM
maturation
calcium
handling.
RNA
sequencing
demonstrated
that
promotes
mature
phenotype
hiPSC‐CMs
by
upregulating
ion
channel
genes.
Using
scaffold,
multi‐cellular
EHT
successfully
constructed,
incorporating
cardiomyocytes,
endothelial
cells,
mesenchymal
These
complex
EHTs
significantly
enhanced
engraftment
vivo,
attenuated
ventricular
remodeling,
function
mouse
myocardial
infarction.
In
summary,
myocardium‐specific
structured
developed
this
study
represents
promising
advancement
cardiovascular
regenerative
medicine.
Tissue
damage
often
causes
considerable
suffering
to
patients
due
slow
recovery
and
poor
prognosis.
The
use
of
electroactive
materials
deliver
biophysical
signals
plays
a
key
role
in
regulating
tissue
regeneration
processes.
Among
these
materials,
piezoelectric
have
unique
electromechanical
conversion
capabilities,
making
them
suitable
for
as
cell
scaffolds.
They
can
deform
emit
electrical
response
external
stimuli,
thereby
proliferation
differentiation.
In
this
review,
recent
advances
are
presented
physical
signaling
mediators
that
regulate
basic
mechanisms,
classification
their
different
applications
described.
Finally,
comprehensive
discussion
current
challenges
prospects
the
field
is
provided.
Together,
existing
experimental
results
basically
show
improve
process
effect
repair,
providing
new
technical
options
development
engineering
future.
