Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 21, 2023
Abstract
The
formulation
of
an
antibiotic-free
antibacterial
approach
is
imperative
in
circumventing
escalating
bacterial
drug
resistance.
Electrical
stimulation
presents
a
viable
therapeutic
modality
for
such
approach.
Nonetheless,
obstacles
persist
achieving
efficacious
sterilization
with
biosafe
low-voltage
electrical
fields
(EFs)
and
enduring
capabilities.
In
this
study,
we
have
devised
novel
capacitive
dressing
comprising
polypyrrole-wrapped
carbon
cloth
(PPy-CC)
electrodes
cellulose
(BC)
hydrogel
separator.
Subjected
to
1V
10
minutes,
the
attains
high
bactericidal
efficiency
(up
99.97%)
enhanced
activity
against
multidrug-resistant
(MDR)
bacteria
99.99%).
Its
considerable
electric
capacity
rechargeability
allow
repeated
charging
achieve
sustained
sterilization.
vivo
results
demonstrate
significant
inhibition
wound
infection
facilitated
recovery
infected
full-thickness
defects
mouse
models.
This
represents
antibiotic-free,
physically-stimulated
treatment
wounds
potential
clinical
application.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 12, 2024
Abstract
Harnessing
the
robust
electromechanical
couplings,
piezoelectric
materials
not
only
enable
efficient
bio‐energy
harvesting,
physiological
sensing
and
actuating
but
also
open
enormous
opportunities
for
therapeutic
treatments
through
surface
polarization
directly
interacting
with
electroactive
cells,
tissues,
organs.
Known
its
highly
oriented
hierarchical
structure,
collagen
in
natural
bones
produces
local
electrical
signals
to
stimulate
osteoblasts
promote
bone
formation,
inspiring
application
of
orthopedic
medicine.
Recent
studies
showed
that
piezoelectricity
can
impact
microenvironments
by
regulating
molecular
sensors
including
ion
channels,
cytoskeletal
elements,
cell
adhesion
proteins,
other
signaling
pathways.
This
review
thus
focuses
on
discussing
pioneering
applications
diagnosis
treatment
diseases,
aiming
offer
valuable
insights
advancing
next‐generation
medical
technologies.
Beginning
an
introduction
principles
various
materials,
this
paper
delves
into
mechanisms
which
accelerated
osteogenesis.
A
comprehensive
overview
devices,
systems
enhancing
tissue
repair,
alleviating
inflammation
at
infection
sites,
monitoring
health
is
then
provided,
respectively.
Finally,
major
challenges
faced
conditions
are
thoroughly
discussed,
along
a
critical
outlook
future
development
trends.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
Tissue
repair
and
reconstruction
are
a
clinical
difficulty.
Bioelectricity
has
been
identified
as
critical
factor
in
supporting
tissue
cell
viability
during
the
process,
presenting
substantial
potential
for
application.
This
review
delves
into
various
sources
of
electrical
stimulation
identifies
appropriate
electrode
materials
use.
It
also
highlights
biological
mechanisms
at
both
subcellular
cellular
levels,
elucidating
how
these
interactions
facilitate
regeneration
processes
across
different
organs.
Moreover,
specific
outlined,
detailing
their
impact
on
activity.
The
future
development
trends
projected
from
two
perspectives:
optimization
equipment
performance
fulfillment
demands,
focusing
feasibility,
safety,
cost-effectiveness
technologies.
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 21, 2023
Abstract
The
formulation
of
an
antibiotic-free
antibacterial
approach
is
imperative
in
circumventing
escalating
bacterial
drug
resistance.
Electrical
stimulation
presents
a
viable
therapeutic
modality
for
such
approach.
Nonetheless,
obstacles
persist
achieving
efficacious
sterilization
with
biosafe
low-voltage
electrical
fields
(EFs)
and
enduring
capabilities.
In
this
study,
we
have
devised
novel
capacitive
dressing
comprising
polypyrrole-wrapped
carbon
cloth
(PPy-CC)
electrodes
cellulose
(BC)
hydrogel
separator.
Subjected
to
1V
10
minutes,
the
attains
high
bactericidal
efficiency
(up
99.97%)
enhanced
activity
against
multidrug-resistant
(MDR)
bacteria
99.99%).
Its
considerable
electric
capacity
rechargeability
allow
repeated
charging
achieve
sustained
sterilization.
vivo
results
demonstrate
significant
inhibition
wound
infection
facilitated
recovery
infected
full-thickness
defects
mouse
models.
This
represents
antibiotic-free,
physically-stimulated
treatment
wounds
potential
clinical
application.
