Advanced Functional Materials,
Год журнала:
2023,
Номер
34(2)
Опубликована: Сен. 22, 2023
Abstract
Hydrophilic
lubricant
coatings
with
antifouling
properties
are
commercially
applied
to
urological
devices,
such
as
ureteral
stents
(USs),
inhibit
biofilm
formation
and
reduce
the
likelihood
of
infectious
encrustation.
However,
their
long‐term
effectiveness
is
limited
due
lack
active
precise
antibacterial
activity.
Herein,
this
work
reports
a
hydrophilic
(defined
SA‐PU/PVP)
coating
smart
urease‐responsive
antibiotic
release
functionality,
achieved
by
incorporating
sulfanilamide‐conjugated
polyurethane
(SA‐PU)
polymers
into
commercial
agent
containing
polyvinylpyrrolidone
(PVP).
During
initial
implantation
period,
PVP
chains
rapidly
absorb
urine
on
interface,
forming
lubricating
layer
desired
activities
that
attachment
host
proteins,
bacteria,
urate
crystals
over
90%.
As
time
progresses
bacteria
proliferates
produces
urease,
urease
enzymatically
degrades
urea
linkages
in
SA‐PU/PVP
coating,
actively
releasing
SA
antibiotics
demand
prevent
Benefiting
from
synergistic
activities,
SA‐PU/PVP‐coated
US
exhibits
superior
performance
preventing
encrustation
porcine
model
7‐week
surpassing
US.
This
strategy
offers
practical
solution
for
inhibiting
device‐associated
complications.
ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
10(5), С. 3057 - 3068
Опубликована: Апрель 19, 2024
Blood-contacting
catheters
play
a
pivotal
role
in
contemporary
medical
treatments,
particularly
the
management
of
cardiovascular
diseases.
However,
these
exhibit
inappropriate
wettability
and
lack
antimicrobial
characteristics,
which
often
lead
to
catheter-related
infections
thrombosis.
Therefore,
there
is
an
urgent
need
for
blood
contact
with
anticoagulant
properties.
In
this
study,
we
employed
tannic
acid
(TA)
3-aminopropyltriethoxysilane
(APTES)
create
stable
hydrophilic
coating
under
mild
conditions.
Heparin
(Hep)
poly(lysine)
(PL)
were
then
modified
on
TA-APTES
surface
using
layer-by-layer
(LBL)
technique
superhydrophilic
TA/APTES/(LBL)4
silicone
rubber
(SR)
catheters.
Leveraging
nature
coating,
it
can
be
effectively
applied
blood-contacting
impart
antibacterial,
antiprotein
adsorption,
Due
Hep's
attributes,
activated
partial
thromboplastin
time
thrombin
tests
conducted
SR/TA-APTES/(LBL)4
revealed
remarkable
extensions
276
103%,
respectively,
when
compared
uncoated
commercial
SR
Furthermore,
synergistic
interaction
between
PL
TA
serves
enhance
resistance
against
bacterial
adherence,
reducing
by
up
99.9%
Remarkably,
catheter
exhibits
good
biocompatibility
human
umbilical
vein
endothelial
cells
culture,
positioning
as
promising
solution
address
current
challenges
associated
blood-contact
Macromolecular Rapid Communications,
Год журнала:
2024,
Номер
45(8)
Опубликована: Янв. 19, 2024
Wound
healing
in
movable
parts,
including
the
joints
and
neck,
remains
a
critical
challenge
due
to
frequent
motions
poor
flexibility
of
dressings,
which
may
lead
mismatching
mechanical
properties
fitting
between
dressings
wounds;
thus,
increasing
risk
bacterial
infection.
This
study
proposes
sprayable
zwitterionic
antibacterial
hydrogel
with
outstanding
desirable
adhesion.
precursor
is
fabricated
by
combining
sulfobetaine
methacrylate
(SBMA)
poly(sulfobetaine
methacrylate-co-dopamine
methacrylamide)-modified
silver
nanoparticles
(PSBDA@AgNPs)
through
robust
electrostatic
interactions.
About
150
s
exposure
UV
light,
SBMA
monomer
polymerizes
form
PSB
chains
entangled
PSBDA@AgNPs,
transformed
into
stable
adhesion
PSB-PSB@Ag
at
wound
site.
The
resulting
has
adhesive
strength
(15-38
kPa),
large
tensile
strain
(>400%),
suitable
shape
adaptation,
excellent
resilience.
Moreover,
displays
pH-responsive
behavior;
acidic
microenvironment
infected
sites
prompts
rapidly
release
AgNPs
kill
bacteria.
Further,
effect
demonstrated
on
rat
neck
skin
wound,
showing
improved
closing
rate
reduced
inflammation
enhanced
angiogenesis.
Overall,
significant
potential
promote
joint
healing.
Macromolecular Bioscience,
Год журнала:
2023,
Номер
24(3)
Опубликована: Окт. 13, 2023
The
development
of
injectable
hydrogel
dressings
which
are
long-term
moisturizing,
easy-to-apply,
and
effectively
inhibiting
infection
inflammatory
is
essential
to
promote
burn
wound
repairing.
Herein,
an
with
antibacterial,
anti-inflammation
abilities
via
multiple
reversible
interactions
between
cation
guar
gum
(CG)
metallic-polyphenolic
nanoparticles
(PA-Zn
Materials Today Bio,
Год журнала:
2024,
Номер
26, С. 101089 - 101089
Опубликована: Май 11, 2024
Catheter-associated
urinary
tract
infection
(CAUTI)
is
a
common
clinical
problem,
especially
during
long-term
catheterization,
causing
additional
pain
to
patients.
The
development
of
novel
antimicrobial
coatings
needed
prolong
the
service
life
catheters
and
reduce
incidence
CAUTIs.
Herein,
we
designed
an
catheter
coated
with
piezoelectric
zinc
oxide
nanoparticles
(ZnO
NPs)-incorporated
polyvinylidene
difluoride-hexafluoropropylene
(ZnO-PVDF-HFP)
membrane.
ZnO-PVDF-HFP
could
be
stably
onto
silicone
simply
by
one-step
solution
film-forming
method,
very
convenient
for
industrial
production.
In
vitro,
it
was
demonstrated
that
coating
significantly
inhibit
bacterial
growth
formation
biofilm
under
ultrasound-mediated
mechanical
stimulation
even
after
4
weeks.
Importantly,
on
off
activity
as
well
strenth
antibacterial
property
controlled
in
adaptive
manner
via
ultrasound.
rabbit
model,
ZnO-PVDF-HFP-coated
reduced
CAUTIs
compared
clinically-commonly
used
assistance
ultrasonication,
no
side
effect
detected.
Collectively,
study
provided
prevent
occurance
CAUTIs,
whose
on-demand
manner,
situation
promising
application.
Journal of Materials Chemistry B,
Год журнала:
2023,
Номер
11(33), С. 8020 - 8032
Опубликована: Янв. 1, 2023
Antifouling
coatings
based
on
zwitterionic
polymers
have
been
widely
applied
for
surface
modification
of
interventional
blood-contacting
devices
to
combat
thrombosis
and
infection.
However,
the
weak
adhesion
stability
coating
device
is
still
key
challenge.
In
this
work,
biocompatible
mixed-charge
polyurethane
(MPU)
polymers,
that
bear
equal
amounts
cationic
quaternary
amine
groups
anionic
carboxyl
groups,
were
developed
further
uniformly
dip-coated
onto
a
thermoplastic
(TPU)
substrate
with
commercial
aliphatic
isocyanate
cross-linker
(AIC).
During
curing
process,
AIC
not
only
crosslinks
MPU
chains
into
polymer
network
but
also
reacts
hydroxyl
TPU
interlink
substrate,
resulting
in
cross-linking
reinforced
(CMPU)
excellent
mechanical
robustness
strength.
Taking
advantage
feature,
final
CMPU
exhibits
both
antifouling
antibacterial
activities
against
protein
adsorption
bacterial
growth,
respectively,
which
beneficial
effectively
inhibiting
occurrence
vivo
Moreover,
anticoagulation
studies
show
CMPU-coated
catheters
can
prevent
formation
blood
clots
ex
rabbit
circuits
without
anticoagulants.
Hence,
designed
has
immense
potential
address
infection
devices.
Blood-bearing
medical
devices
are
essential
for
the
delivery
of
critical
care
medicine
and
often
required
to
function
weeks
months.
However,
thrombus
formation
on
their
surfaces
can
lead
reduced
device
failure
expose
patients
systemic
thrombosis
risks.
While
clinical
anticoagulants
reduce
related
thrombosis,
they
also
increase
patient
bleeding
risk.
The
root
cause
inflammation
is
protein
adsorption
biomaterial
these
devices.
Protein
activates
coagulation
cascade
complement,
this,
in
turn,
platelets
white
blood
cells.
Surface
modifications
with
zwitterionic
polymers
particularly
effective
at
reducing
as
well
conformational
changes
proteins
due
hydrophilicity.
Multiple
coating
strategies
have
been
developed
using
carboxybetaine
(CB),
sulfobetaine
(SB),
2-methacryloyloxyethyl
phosphorylcholine
(MPC)
applied
metals
hydrophobic
that
make
up
bulk
blood-bearing
These
coatings
highly
successful
creating
large
reductions
platelet
adhesion
during
studies
order
hours
flat
a
few
days
full
Future
work
needs
focus
ability
limit
inflammation,
hemodialysis,
providing
anticoagulation
weeks,
artificial
lungs.
