Angewandte Chemie,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Abstract
Infectious
diseases
pose
considerable
challenges
to
public
health,
particularly
with
the
rise
of
multidrug‐resistant
pathogens
that
globally
cause
high
mortality
rates.
These
can
persist
on
surfaces
and
spread
in
healthcare
settings.
Advances
have
been
made
developing
antimicrobial
materials
reduce
transmission
pathogens,
including
composed
naturally
sourced
polyphenols
their
derivatives,
which
exhibit
potency,
broad‐spectrum
activity,
a
lower
likelihood
promoting
resistance.
This
review
provides
an
overview
recent
advances
fabrication
phenolic
biomaterials,
where
natural
compounds
act
as
active
agents
or
encapsulate
other
(e.g.,
metal
ions,
peptides,
biopolymers).
Various
forms
biomaterials
synthesized
through
these
two
strategies,
particles,
capsules,
hydrogels,
coatings,
are
summarized,
focus
application
wound
healing,
bone
repair
regeneration,
oral
coatings
for
medical
devices.
The
potential
advanced
promising
therapeutic
approach
combating
antimicrobial‐resistant
infections
reducing
microbial
transmission.
Bioactive Materials,
Год журнала:
2024,
Номер
36, С. 62 - 82
Опубликована: Фев. 28, 2024
Tendon-bone
interface
injuries
pose
a
significant
challenge
in
tissue
regeneration,
necessitating
innovative
approaches.
Hydrogels
with
integrated
supportive
features
and
controlled
release
of
therapeutic
agents
have
emerged
as
promising
candidates
for
the
treatment
such
injuries.
In
this
study,
we
aimed
to
develop
temperature-sensitive
composite
hydrogel
capable
providing
sustained
magnesium
ions
(Mg2+).
We
synthesized
magnesium-Procyanidin
coordinated
metal
polyphenol
nanoparticles
(Mg-PC)
through
self-assembly
process
them
into
two-component
hydrogel.
The
was
composed
dopamine-modified
hyaluronic
acid
(Dop-HA)
F127.
To
ensure
mitigate
"burst
release"
effect
Mg2+,
covalently
crosslinked
Mg-PC
coordination
bonds
catechol
moiety
within
This
crosslinking
strategy
extended
window
Mg2+
concentrations
up
56
days.
resulting
(Mg-PC@Dop-HA/F127)
exhibited
favorable
properties,
including
injectability,
thermosensitivity
shape
adaptability,
making
it
suitable
injection
adaptation
irregularly
shaped
supraspinatus
implantation
sites.
Furthermore,
Procyanidins,
which
attracted
mesenchymal
stem
progenitor
cells,
alleviated
inflammation,
promoted
macrophage
polarization
towards
M2
phenotype.
Additionally,
enhanced
collagen
synthesis
mineralization,
facilitating
repair
tendon-bone
interface.
By
incorporating
multilevel
phenolic
networks
(MPN)
control
ion
release,
these
hybridized
hydrogels
can
be
customized
various
biomedical
applications.
Abstract
Infected
bone
defects
are
one
of
the
most
challenging
problems
in
treatment
due
to
high
antibiotic
failure
rate
and
lack
ideal
grafts.
In
this
paper,
inspired
by
clinical
cement
filling
treatment,
α
‐c
phosphate
(
‐TCP)
with
self‐curing
properties
is
composited
β
‐tricalcium
constructed
a
bionic
cancellous
scaffolding
system
α/β‐tricalcium
/
low‐temperature
3D
printing,
gelatin
preserved
inside
scaffolds
as
an
organic
phase,
later
loaded
metal–polyphenol
network
structure
tea
polyphenol‐magnesium
(TP‐Mg)
nanoparticles.
The
mimic
components
mechanical
strength
(>100
MPa)
based
on
‐TCP
through
printing.
Meanwhile,
TP‐Mg
exhibit
significant
inhibition
Staphylococcus
aureus
S.aureus
)
promote
transition
macrophages
from
M1
pro‐inflammatory
M2
anti‐inflammatory
phenotype.
addition,
composite
scaffold
also
exhibits
excellent
bone‐enhancing
effects
synergistic
effect
Mg
2+
Ca
.
study,
multifunctional
ceramic
‐TCP@TP‐Mg)
that
integrates
anti‐inflammatory,
antibacterial,
osteoinduction
constructed,
which
promotes
late
regenerative
healing
while
modulating
early
microenvironment
infected
defects,
has
promising
application
defects.
Angewandte Chemie International Edition,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Abstract
Infectious
diseases
pose
considerable
challenges
to
public
health,
particularly
with
the
rise
of
multidrug‐resistant
pathogens
that
globally
cause
high
mortality
rates.
These
can
persist
on
surfaces
and
spread
in
healthcare
settings.
Advances
have
been
made
developing
antimicrobial
materials
reduce
transmission
pathogens,
including
composed
naturally
sourced
polyphenols
their
derivatives,
which
exhibit
potency,
broad‐spectrum
activity,
a
lower
likelihood
promoting
resistance.
This
review
provides
an
overview
recent
advances
fabrication
phenolic
biomaterials,
where
natural
compounds
act
as
active
agents
or
encapsulate
other
(e.g.,
metal
ions,
peptides,
biopolymers).
Various
forms
biomaterials
synthesized
through
these
two
strategies,
particles,
capsules,
hydrogels,
coatings,
are
summarized,
focus
application
wound
healing,
bone
repair
regeneration,
oral
coatings
for
medical
devices.
The
potential
advanced
promising
therapeutic
approach
combating
antimicrobial‐resistant
infections
reducing
microbial
transmission.
Military Medical Research,
Год журнала:
2025,
Номер
12(1)
Опубликована: Март 3, 2025
Abstract
Bone
tissue
relies
on
the
intricate
interplay
between
blood
vessels
and
nerve
fibers,
both
are
essential
for
many
physiological
pathological
processes
of
skeletal
system.
Blood
provide
necessary
oxygen
nutrients
to
bone
tissues,
remove
metabolic
waste.
Concomitantly,
fibers
precede
during
growth,
promote
vascularization,
influence
cells
by
secreting
neurotransmitters
stimulate
osteogenesis.
Despite
critical
roles
components,
current
biomaterials
generally
focus
enhancing
intraosseous
vessel
repair,
while
often
neglecting
contribution
nerves.
Understanding
distribution
main
functions
in
is
crucial
developing
effective
engineering.
This
review
first
explores
anatomy
highlighting
their
vital
embryonic
development,
metabolism,
repair.
It
covers
innovative
regeneration
strategies
directed
at
accelerating
intrabony
neurovascular
system
over
past
10
years.
The
issues
covered
included
material
properties
(stiffness,
surface
topography,
pore
structures,
conductivity,
piezoelectricity)
acellular
biological
factors
[neurotrophins,
peptides,
ribonucleic
acids
(RNAs),
inorganic
ions,
exosomes].
Major
challenges
encountered
neurovascularized
materials
clinical
translation
have
also
been
highlighted.
Furthermore,
discusses
future
research
directions
potential
developments
aimed
producing
repair
that
more
accurately
mimic
natural
healing
tissue.
will
serve
as
a
valuable
reference
researchers
clinicians
novel
into
practice.
By
bridging
gap
experimental
practical
application,
these
advancements
transform
treatment
defects
significantly
improve
quality
life
patients
with
bone-related
conditions.
Periodontology 2000,
Год журнала:
2023,
Номер
94(1), С. 213 - 230
Опубликована: Окт. 12, 2023
The
use
of
biomaterials
in
regenerative
medicine
has
expanded
to
treat
various
disorders
caused
by
trauma
or
disease
orthopedics
and
dentistry.
However,
the
treatment
large
complex
bone
defects
presents
a
challenge,
leading
pressing
need
for
optimized
repair.
Recent
advances
chemical
sciences
have
enabled
incorporation
therapeutic
ions
into
grafts
enhance
their
performance.
These
ions,
such
as
strontium
(for
regeneration/osteoporosis),
copper
angiogenesis),
boron
growth),
iron
chemotaxis),
cobalt
B12
synthesis),
lithium
osteogenesis/cementogenesis),
silver
antibacterial
resistance),
magnesium
cartilage
regeneration),
among
others
(e.g.,
zinc,
sodium,
silica),
been
studied
extensively.
This
review
aims
provide
comprehensive
overview
current
knowledge
recent
developments
ion
periodontal
tissue
It
also
discusses
recently
developed
from
basic
design
clinical
application
perspective.
Additionally,
highlights
importance
precise
introduction
address
existing
limitations
challenges
combination
therapies.
Future
prospects
opportunities
development
optimization
engineering
are
emphasized.
Pharmaceutics,
Год журнала:
2024,
Номер
16(9), С. 1232 - 1232
Опубликована: Сен. 21, 2024
Silver
nanoparticles
(AgNPs)
are
leading
the
way
in
nanotechnological
innovation,
combining
captivating
properties
of
silver
with
accuracy
nanoscale
engineering,
thus
revolutionizing
material
science.
Three
main
techniques
arise
within
alchemical
domains
AgNP
genesis:
chemical,
physical,
and
biological
synthesis.
Each
possesses
its
distinct
form
magic
for
controlling
size,
shape,
scalability—key
factors
necessary
achieving
expertise
practical
application
nanoparticles.
The
story
unravels,
describing
careful
coordination
chemical
reduction,
environmentally
sensitive
charm
green
synthesis
utilizing
plant
extracts,
precise
physical
techniques.
AgNPs
highly
praised
field
healthcare
their
powerful
antibacterial
characteristics.
These
little
warriors
display
a
wide-ranging
attack
against
bacteria,
fungi,
parasites,
viruses.
Their
critical
significance
combating
hospital-acquired
surgical
site
infections
is
praised,
serving
as
beacon
hope
fight
challenging
problem
antibiotic
resistance.
In
addition
to
ability
kill
also
known
promote
tissue
regeneration
facilitate
wound
healing.
cancer
has
observed
adaptability
AgNPs.
review
documents
role
innovative
carriers
drugs,
specifically
designed
target
cells
accuracy,
minimizing
harm
healthy
tissues.
Additionally,
it
explores
potential
therapy
or
anticancer
agents
capable
disrupting
growth
tumors.
food
business,
utilized
enhance
durability
packing
materials
coatings
by
infusing
them
bactericidal
properties.
This
results
improved
safety
measures
significant
increase
duration
that
products
can
be
stored,
thereby
tackling
crucial
issue
preservation.
academic
analysis
recognizes
many
difficulties
come
creation
incorporation
statement
pertains
evaluation
environmental
effort
synthetic
processes.
predicts
future
pursuits,
envisioning
progress
will
usefulness
importance
from
being
new
becoming
essential
realms
science
industry.
Besides,
not
only
subject
scholarly
interest
but
component
continuous
tackle
some
most
urgent
health
conservation
concerns
contemporary
society.
aims
explore
complex
process
highlight
numerous
uses,
special
focus
on
growing
business
sectors.
invites
scientific
community
extensive
possibilities
order
fully
understand
utilize
potential.
Nanoscale Horizons,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
discusses
commonly
used
semiconductor
photocatalytic
antibacterial
materials,
methods
for
improving
their
photocatalysis
performance
and
application
bone
infection
treatment.
