Journal of Materials Research and Technology,
Год журнала:
2024,
Номер
29, С. 5330 - 5339
Опубликована: Март 1, 2024
Bioabsorbable
zinc
(Zn)-based
materials
for
bone
defect
repair
have
received
increasing
attention.
Based
on
3D
printing
technology,
this
study
innovatively
designed
and
manufactured
pure
Zn
Ti6Al4V
porous
scaffolds.
The
pore
size
of
the
scaffold
was
700
μm
porosity
70%.
Compared
with
traditional
scaffolds,
it
found
that
scaffolds
had
a
larger
deformation,
ultimate
compressive
stress
18
MPa,
but
strain
could
exceed
20%,
while
only
6%.
elastic
modulus
also
lower
than
Ti6Al4V,
which
0.25
GPa,
can
meet
requirements
in
non-weight-bearing
area.
However,
better
capacity
modulus,
so
they
less
stress-shielding
effect
bone.
Degradation
experiments
proved
good
degradation
performance.
Further
vivo
vitro
showed
osteogenic
ability
findings
our
underscore
potential
integrating
into
printed
their
application
orthopedic
scenarios.
Ferroptosis,
caused
by
disorders
of
iron
metabolism,
plays
a
critical
role
in
various
diseases,
making
the
regulation
metabolism
essential
for
tissue
repair.
In
our
analysis
degenerated
intervertebral
disc
tissue,
we
observe
positive
correlation
between
concentration
extracellular
ions
(ex-iron)
and
severity
ferroptosis
degeneration
(IVDD).
Hence,
inspired
magnets
attracting
metals,
combine
polyether
F127
diacrylate
(FDA)
with
tannin
(TA)
to
construct
magnetically
hydrogel
(FDA-TA).
This
demonstrates
capability
adsorb
ex-iron
remodel
cells.
Furthermore,
it
exhibits
good
toughness
self-healing
properties.
Notably,
can
activate
PI3K-AKT
pathway
inhibit
nuclear
receptor
coactivator
4–mediated
ferritinophagy
under
enrichment
conditions.
The
curative
effect
related
mechanism
are
further
confirmed
vivo.
Consequently,
on
basis
pathological
mechanism,
targeted
is
designed
reshape
offering
insights
Biomedicines,
Год журнала:
2024,
Номер
12(2), С. 344 - 344
Опубликована: Фев. 1, 2024
In
orthopedics,
the
repair
of
bone
defects
remains
challenging.
previous
research
reports,
magnesium
phosphate
cements
(MPCs)
were
widely
used
because
their
excellent
mechanical
properties,
which
have
been
in
field
orthopedic
medicine.
We
built
a
new
k-struvite
(MPC)
cement
obtained
from
zinc
oxide
(ZnO)
and
assessed
its
osteogenic
properties.
Zinc-doped
(ZMPC)
is
novel
material
with
good
biocompatibility
degradability.
This
article
summarizes
preparation
method,
physicochemical
biological
properties
ZMPC
through
on
this
material.
The
results
show
that
has
same
strength
toughness
(25.3
±
1.73
MPa
to
20.18
2.11
MPa),
meet
requirements
repair.
Furthermore,
can
gradually
degrade
(12.27%
1.11%
28
days)
promote
differentiation
(relative
protein
expression
level
increased
2–3
times)
rat
marrow
mesenchymal
stem
cells
(rBMSCs)
vitro.
addition,
vivo
confirmation
revealed
regeneration
calvarial
defect
model
compared
MPC
alone.
Therefore,
broad
application
prospects
expected
be
an
important
Journal of Materials Research and Technology,
Год журнала:
2024,
Номер
29, С. 5330 - 5339
Опубликована: Март 1, 2024
Bioabsorbable
zinc
(Zn)-based
materials
for
bone
defect
repair
have
received
increasing
attention.
Based
on
3D
printing
technology,
this
study
innovatively
designed
and
manufactured
pure
Zn
Ti6Al4V
porous
scaffolds.
The
pore
size
of
the
scaffold
was
700
μm
porosity
70%.
Compared
with
traditional
scaffolds,
it
found
that
scaffolds
had
a
larger
deformation,
ultimate
compressive
stress
18
MPa,
but
strain
could
exceed
20%,
while
only
6%.
elastic
modulus
also
lower
than
Ti6Al4V,
which
0.25
GPa,
can
meet
requirements
in
non-weight-bearing
area.
However,
better
capacity
modulus,
so
they
less
stress-shielding
effect
bone.
Degradation
experiments
proved
good
degradation
performance.
Further
vivo
vitro
showed
osteogenic
ability
findings
our
underscore
potential
integrating
into
printed
their
application
orthopedic
scenarios.
