Comparison of osteogenic capability between porous Zn and porous Ti6Al4V scaffolds: An in vivo study DOI Creative Commons
Pu Ying, Fujun Chen,

Linghui Meng

и другие.

Journal of Materials Research and Technology, Год журнала: 2024, Номер 29, С. 5330 - 5339

Опубликована: Март 1, 2024

Bioabsorbable zinc (Zn)-based materials for bone defect repair have received increasing attention. Based on 3D printing technology, this study innovatively designed and manufactured pure Zn Ti6Al4V porous scaffolds. The pore size of the scaffold was 700 μm porosity 70%. Compared with traditional scaffolds, it found that scaffolds had a larger deformation, ultimate compressive stress 18 MPa, but strain could exceed 20%, while only 6%. elastic modulus also lower than Ti6Al4V, which 0.25 GPa, can meet requirements in non-weight-bearing area. However, better capacity modulus, so they less stress-shielding effect bone. Degradation experiments proved good degradation performance. Further vivo vitro showed osteogenic ability findings our underscore potential integrating into printed their application orthopedic scenarios.

Язык: Английский

Investigating the effect of tannin films prepared by low-energy electron beam deposition on the inhibition of bone tumors DOI
Xiaoxue Tan, Hao Chen, Xin Liu

и другие.

Applied Surface Science, Год журнала: 2024, Номер 657, С. 159811 - 159811

Опубликована: Март 1, 2024

Язык: Английский

Процитировано

4

Preparation of an injectable zinc-containing hydrogel with double dynamic bond and its potential application in the treatment of periodontitis DOI Creative Commons
Mei Yang,

Dejiang Du,

Yuanping Hao

и другие.

RSC Advances, Год журнала: 2024, Номер 14(27), С. 19312 - 19321

Опубликована: Янв. 1, 2024

Periodontal tissue regeneration continues to face significant clinical challenges.

Процитировано

4

Magnetically attracting hydrogel reshapes iron metabolism for tissue repair DOI Creative Commons
Yichang Xu, Feng Cai,

Yidi Zhou

и другие.

Science Advances, Год журнала: 2024, Номер 10(33)

Опубликована: Авг. 16, 2024

Ferroptosis, caused by disorders of iron metabolism, plays a critical role in various diseases, making the regulation metabolism essential for tissue repair. In our analysis degenerated intervertebral disc tissue, we observe positive correlation between concentration extracellular ions (ex-iron) and severity ferroptosis degeneration (IVDD). Hence, inspired magnets attracting metals, combine polyether F127 diacrylate (FDA) with tannin (TA) to construct magnetically hydrogel (FDA-TA). This demonstrates capability adsorb ex-iron remodel cells. Furthermore, it exhibits good toughness self-healing properties. Notably, can activate PI3K-AKT pathway inhibit nuclear receptor coactivator 4–mediated ferritinophagy under enrichment conditions. The curative effect related mechanism are further confirmed vivo. Consequently, on basis pathological mechanism, targeted is designed reshape offering insights

Язык: Английский

Процитировано

4

Exploring the Osteogenic Potential of Zinc-Doped Magnesium Phosphate Cement (ZMPC): A Novel Material for Orthopedic Bone Defect Repair DOI Creative Commons
Yinchu Liu, Ling Yu,

Jingteng Chen

и другие.

Biomedicines, Год журнала: 2024, Номер 12(2), С. 344 - 344

Опубликована: Фев. 1, 2024

In orthopedics, the repair of bone defects remains challenging. previous research reports, magnesium phosphate cements (MPCs) were widely used because their excellent mechanical properties, which have been in field orthopedic medicine. We built a new k-struvite (MPC) cement obtained from zinc oxide (ZnO) and assessed its osteogenic properties. Zinc-doped (ZMPC) is novel material with good biocompatibility degradability. This article summarizes preparation method, physicochemical biological properties ZMPC through on this material. The results show that has same strength toughness (25.3 ± 1.73 MPa to 20.18 2.11 MPa), meet requirements repair. Furthermore, can gradually degrade (12.27% 1.11% 28 days) promote differentiation (relative protein expression level increased 2–3 times) rat marrow mesenchymal stem cells (rBMSCs) vitro. addition, vivo confirmation revealed regeneration calvarial defect model compared MPC alone. Therefore, broad application prospects expected be an important

Язык: Английский

Процитировано

3

Comparison of osteogenic capability between porous Zn and porous Ti6Al4V scaffolds: An in vivo study DOI Creative Commons
Pu Ying, Fujun Chen,

Linghui Meng

и другие.

Journal of Materials Research and Technology, Год журнала: 2024, Номер 29, С. 5330 - 5339

Опубликована: Март 1, 2024

Bioabsorbable zinc (Zn)-based materials for bone defect repair have received increasing attention. Based on 3D printing technology, this study innovatively designed and manufactured pure Zn Ti6Al4V porous scaffolds. The pore size of the scaffold was 700 μm porosity 70%. Compared with traditional scaffolds, it found that scaffolds had a larger deformation, ultimate compressive stress 18 MPa, but strain could exceed 20%, while only 6%. elastic modulus also lower than Ti6Al4V, which 0.25 GPa, can meet requirements in non-weight-bearing area. However, better capacity modulus, so they less stress-shielding effect bone. Degradation experiments proved good degradation performance. Further vivo vitro showed osteogenic ability findings our underscore potential integrating into printed their application orthopedic scenarios.

Язык: Английский

Процитировано

3