Catalytic Biomaterials‐Activated In Situ Chemical Reactions: Strategic Modulation and Enhanced Disease Treatment

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 5, 2024

Abstract Chemical reactions underpin biological processes, and imbalances in critical biochemical pathways within organisms can lead to the onset of severe diseases. Within this context, emerging field “Nanocatalytic Medicine” leverages nanomaterials as catalysts modulate fundamental chemical specific microenvironments This approach is designed facilitate targeted synthesis localized accumulation therapeutic agents, thus enhancing treatment efficacy precision while simultaneously reducing systemic side effects. The effectiveness these nanocatalytic strategies critically hinges on a profound understanding kinetics intricate interplay particular pathological ensure effective catalytic actions. review methodically explores situ their associated biomaterials, emphasizing regulatory that control responses. Furthermore, discussion encapsulates crucial elements‐reactants, catalysts, reaction conditions/environments‐necessary for optimizing thermodynamics reactions, rigorously addressing both biophysical dimensions disease enhance outcomes. It seeks clarify mechanisms underpinning biomaterials evaluate potential revolutionize across various conditions.

Язык: Английский

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Polypeptide Nanoparticles Obstruct Glucose Supply for NIR-II Fluorescence-Guided Tumor Starvation and Enhanced Mild Photothermal Therapy

Опубликована: Янв. 1, 2025

Photothermal therapy (PTT) utilizes localized hyperthermia above 50°C generated by nanomaterials upon exposure to near-infrared (NIR) laser light for effective cancer cell eradication. Yet, in high-temperature PTT, tumor cells develop heat stress tolerance due elevated shock protein (HSP) levels, diminishing therapeutic efficacy. Moreover, excessive can trigger inflammatory conditions and promote metastasis. Targeting the glycolytic pathway highly metabolically active offers a promising strategy inducing starvation therapy, capitalizing on their vigorous energy demands amidst rapid proliferation. Here, Initially, we synthesized luminous NIR-II dye, FNF, followed its encapsulation alongside myricetin (My) within amphiphilic polypeptide carriers through self-assembly method. The resulting nanoparticles exhibited excellent imaging capabilities boasted notable photothermal conversion efficiency of 55.58%. Furthermore, Myricetin effectively impeded glucose transport facilitated transporter 1 (GLUT1), curtailing supply cells. This interference disrupted mitochondrial production, leading decreased adenosine triphosphate (ATP) synthesis subsequent downregulation HSP70 expression. By leveraging this approach, which targets HSP expression via GLUT1 inhibition, enhance efficacy PTT while achieving synergistic effect mild starvation.

Язык: Английский

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Preparation and Application of Enzyme-based Hydrogels

Biosensors and Bioelectronics X, Год журнала: 2025, Номер unknown, С. 100594 - 100594

Опубликована: Фев. 1, 2025

Язык: Английский

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Harnessing stimuli-responsive NO nanomaterials for advanced multi-disease therapy

Coordination Chemistry Reviews, Год журнала: 2025, Номер 533, С. 216540 - 216540

Опубликована: Фев. 27, 2025

Язык: Английский

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sEmerging glucose oxidase-delivering nanomedicines for enhanced tumor therapy

Journal of Controlled Release, Год журнала: 2025, Номер 381, С. 113580 - 113580

Опубликована: Фев. 28, 2025

Язык: Английский

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