3D printing in biomedicine: advancing personalized care through additive manufacturing

Exploration of Medicine, Год журнала: 2023, Номер unknown, С. 1135 - 1167

Опубликована: Дек. 29, 2023

The integration of three-dimensional (3D) printing techniques into the domains biomedical research and personalized medicine highlights evolving paradigm shifts within contemporary healthcare. This technological advancement signifies potential breakthroughs in patient-specific therapeutic interventions innovations. systematic review offers a critical assessment existing literature, elucidating present status, inherent challenges, prospective avenues 3D augmenting applications formulating tailored medical strategies. Based on an exhaustive literature analysis comprising empirical studies, case extensive reviews from past decade, pivotal sectors including tissue engineering, prosthetic development, drug delivery systems, customized apparatuses are delineated. advent provides precision fabrication patient-centric implants, bio-structures, devices, thereby mitigating associated risks. Concurrently, it facilitates ideation individualized paradigms to optimize outcomes. Notwithstanding these advancements, issues concerning material biocompatibility, regulatory compliance, economic implications avant-garde persist. To fully harness transformative healthcare, collaborative endeavors amongst academicians, clinicians, industrial entities, bodies paramount. With continued innovation, is poised redefine trajectories science care. paper aims justify objective whether what extent technology biomedicine enhances treatment contributes improved healthcare

Язык: Английский

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Additive manufacturing in the new space economy: Current achievements and future perspectives

Progress in Aerospace Sciences, Год журнала: 2023, Номер 142, С. 100959 - 100959

Опубликована: Окт. 1, 2023

Язык: Английский

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3D Bioprinting in Microgravity: Opportunities, Challenges, and Possible Applications in Space

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(23)

Опубликована: Июнь 23, 2023

Abstract 3D bioprinting has developed tremendously in the last couple of years and enables fabrication simple, as well complex, tissue models. The international space agencies have recognized unique opportunities these technologies for manufacturing cell models basic research space, particular investigating effects microgravity cosmic radiation on different types human tissues. In addition, is capable producing clinically applicable grafts, its implementation therefore can support autonomous medical treatment options astronauts future long term far‐distant missions. article discusses but also challenges operating bioprinters under conditions, mainly microgravity. While some process steps, most which involving handling liquids, are challenging microgravity, this environment help overcome problems such sedimentation low viscous bioinks. Hopefully, publication will motivate more researchers to engage topic, with publicly available becoming at International Space Station (ISS) imminent future.

Язык: Английский

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Light from Afield: Fast, High-Resolution, and Layer-Free Deep Vat 3D Printing

Chemical Reviews, Год журнала: 2024, Номер 124(14), С. 8787 - 8822

Опубликована: Июль 5, 2024

Harnessing light for cross-linking of photoresponsive materials has revolutionized the field 3D printing. A wide variety techniques leveraging broad-spectrum shaping have been introduced as a way to achieve fast and high-resolution printing, with applications ranging from simple prototypes biomimetic engineered tissues regenerative medicine. Conventional light-based printing use material in layer-by-layer fashion produce complex parts. Only recently, new emerged which deploy multidirection, tomographic, light-sheet or filamented image projections deep into volume resin-filled vat photoinitiation cross-linking. These Deep Vat (DVP) approaches alleviate need layer-wise enable unprecedented fabrication speeds (within few seconds) high resolution (>10 μm). Here, we elucidate physics chemistry these processes, their commonalities differences, well emerging biomedical non-biomedical fields. Importantly, highlight limitations, future scope research that will improve scalability applicability DVP engineering medicine applications.

Язык: Английский

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Drug delivery pathways to the central nervous system via the brain glymphatic system circumventing the blood‐brain barrier

Exploration, Год журнала: 2024, Номер unknown

Опубликована: Июль 9, 2024

The blood-brain barrier (BBB) poses daunting challenges in treating diseases associated with the central nervous system (CNS). Recently, traditional notion of absence lymphatic brain is evolving. discovery glymphatic has stimulated tremendous interest developing new strategies for treatment CNS diseases. Leveraging drug delivery may pave a avenue to circumvent BBB and achieve efficient delivery. review focuses on brain, discussing potential factors affecting its functions exploring their connections meningeal system. Finally, provides an overview methods through regulate immunity. These innovative significantly improve utilization create avenues

Язык: Английский

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Omics Studies of Specialized Cells and Stem Cells under Microgravity Conditions

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(18), С. 10014 - 10014

Опубликована: Сен. 17, 2024

The primary objective of omics in space with focus on the human organism is to characterize and quantify biological factors that alter structure, morphology, function, dynamics cells exposed microgravity. This review discusses exciting data regarding genomics, transcriptomics, epigenomics, metabolomics, proteomics individuals space, as well cultured under simulated NASA Twins Study significantly heightened interest applying technologies bioinformatics terrestrial environments. Here, we present available publications this field a specialized stem real microgravity conditions. We summarize current knowledge following topics: (i) studies cells, (ii) benign different cell types organism, (iii) discussing advantages for commercialization exploration, (iv) summarizing emerging opportunities translational regenerative medicine travelers patients Earth.

Язык: Английский

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Satellite‐Based On‐Orbit Printing of 3D Tumor Models

Advanced Materials, Год журнала: 2023, Номер 36(34)

Опубликована: Дек. 26, 2023

Space three dimension (3D） bioprinting provides a precise and bionic tumor model for evaluating the compound effect of space environment on tumors, thereby providing insight into progress disease potential treatments. However, 3D faces several challenges, including prelaunch uncertainty, possible liquid leakage, long-term culture in space, automatic equipment control, data acquisition, transmission. Here, novel satellite-based device with high structural strength, small volume, low weight (<6 kg) is developed. A microgel-based biphasic thermosensitive bioink suspension medium that supports on-orbit printing situ complex models An intelligent control algorithm enables printing, autofocusing, fluorescence imaging, transfer back to ground To authors' knowledge, this first time achieved stable morphology moderate viability via satellite. It found are more sensitive antitumor drugs than Earth. This study opens up new avenue offers possibilities future research life science medicine.

Язык: Английский

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Advanced material technologies for space and terrestrial medicine

Nature Reviews Materials, Год журнала: 2024, Номер unknown

Опубликована: Июнь 3, 2024

Язык: Английский

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Advanced Bioprinting for the Future

Опубликована: Июль 5, 2024

Язык: Английский

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Electrohydrodynamic Direct‐Writing Micro/Nanofibrous Architectures: Principle, Materials, and Biomedical Applications

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Июнь 7, 2024

Electrohydrodynamic (EHD) direct-writing has recently gained attention as a highly promising additive manufacturing strategy for fabricating intricate micro/nanoscale architectures. This technique is particularly well-suited mimicking the extracellular matrix (ECM) present in biological tissue, which serves vital function facilitating cell colonization, migration, and growth. The integration of EHD with other techniques been employed to enhance performance scaffolds, significant advancements have made development tailored scaffold architectures constituents meet specific requirements various biomedical applications. Here, comprehensive overview provided, including its underlying principles, demonstrated materials systems, A brief chronology along an examination observed phenomena that occur during printing process. impact biomaterial selection architectural topographic cues on also highlighted. Finally, major limitations associated are discussed.

Язык: Английский

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