Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Сен. 19, 2024
Язык: Английский
AAPS PharmSciTech, Год журнала: 2025, Номер 26(3)
Опубликована: Март 7, 2025
Язык: Английский
Процитировано
0
Food Bioscience, Год журнала: 2025, Номер unknown, С. 106647 - 106647
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Май 12, 2025
RNA interference (RNAi) has emerged as a transformative approach for cancer therapy, enabling precise gene silencing through small interfering (siRNA). However, the clinical application of siRNA-based treatments faces challenges such rapid degradation, inefficient cellular uptake, and immune system clearance. Nanotechnology-enhanced siRNA delivery revolutionized therapy by addressing these limitations, improving stability, tumor-specific targeting, therapeutic efficacy. Recent advancements in nanocarrier engineering have introduced innovative strategies to enhance safety precision therapies, offering new opportunities personalized medicine. This review highlights three key innovations nanotechnology-enhanced delivery: artificial intelligence (AI)-driven design, multifunctional nanoparticles combined strategies, biomimetic nanocarriers enhanced biocompatibility. AI-driven utilize machine learning algorithms optimize nanoparticle properties, drug release profiles minimizing off-target effects. Multifunctional integrate with chemotherapy, immunotherapy, or photothermal synergistic treatment approaches that outcomes reduce resistance. Biomimetic nanocarriers, including exosome-mimicking systems cell-membrane-coated nanoparticles, improve circulation time, evasion, targeted tumor delivery. These collectively precision, efficiency, therapies. The scope novelty lie their ability overcome primary barriers while paving way clinically viable solutions. provides comprehensive analysis latest developments fabrication, preclinical studies, assessments. By integrating multifunctionality, biomimicry, holds immense potential future therapy.
Язык: Английский
Процитировано
0
Discover Food, Год журнала: 2025, Номер 5(1)
Опубликована: Май 17, 2025
Язык: Английский
Процитировано
0
ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown
Опубликована: Май 21, 2025
RNA therapeutics represent a pivotal advancement in contemporary medicine, pioneering innovative treatments oncology and vaccine production. The inherent instability of its delivery challenges necessitate the use lipid-based nanoparticles as crucial transport vehicles. This research focuses on design, simulation, optimization various microfluidic channel configurations for fabricating poly(dimethylsiloxane) (PDMS) chips, aimed at producing lipid (LNPs) encapsulating green fluorescent protein mRNA (GFP mRNA). Aiming high mixing efficiency acceptable pressure drop suitable scale-up, we designed improved multiple channels featuring flow focusing diverse tilted rectangular baffle structures via computational fluid dynamics (CFD). Simulation results indicated that angles ranging from 70 to 90° exhibited similar efficiencies different total rates, with drops increasing alongside angle. Additionally, length fixed angle 70° not only but also increased drop. To validate these findings, PDMS chips were fabricated all designs prepare empty LNPs. structure 150 μm was identified best configuration based both simulation experimental results. optimal design then used LNPs varying GFP concentrations, demonstrating an N/P ratio 5.6 yielded highest transfection vitro experiments. work advances production through microfluidics provides scalable reproducible method can potentially enhance clinical translation therapeutics.
Язык: Английский
Процитировано
0
Food Hydrocolloids for Health, Год журнала: 2025, Номер unknown, С. 100224 - 100224
Опубликована: Июнь 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Sustainable Food Systems, Год журнала: 2024, Номер 8
Опубликована: Июль 31, 2024
Introduction Animal waste proteins have been increasing in the past decade, along with consumer demands. Their huge volume and environmental issues caused by improper treatment probably pose a massive threat to human health. These animal contain many valuable bioactive peptides can be used not only as nutrient substances but also primary functional ingredients industries, including agriculture, food, pharmaceuticals. However, advancement of value-added application within 10 years has elucidated yet. In this regard, paper scrutinized studies on applications hydrolysates from throughout last hoping display whole picture their value-adding applications. Methods The Web Science Google Scholar were searched January 1, 2013, December 12, 2023. This review included field trials, vitro vivo assays, silico analysis based literature surveys or proteolysis simulation. quality was evaluated Journal Citation Reports, rationality discussion included. Results Numerous performed potential agricultural, medicinal industries. Particularly, due nutritional value, safety, especially competitive effects, peptide antioxidant, antimicrobial, antihypertensive, antidiabetic, antithrombotic activities ingredient food Discussion could step towards sustainable by-products management, simultaneously, open new avenues rapid development nutraceuticals further bioavailability structure-activity relationship are required verify therapeutic effects.
Язык: Английский
Процитировано
2
Potato Research, Год журнала: 2024, Номер unknown
Опубликована: Авг. 30, 2024
Язык: Английский
Процитировано
2
Food Chemistry, Год журнала: 2024, Номер unknown, С. 141708 - 141708
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
2
Journal of Food Science, Год журнала: 2024, Номер unknown
Опубликована: Окт. 22, 2024
Abstract Purple potato anthocyanins (PPAs) are recognized for their broad physiological activities, including significant antioxidant, antimicrobial, and gut microbiota‐regulating effects. However, limited bioavailability in biological systems restricts the full realization of these potentials. In order to improve PPA, this paper established optimized preparation process W/O/W purple anthocyanin nanoparticles (PPA‐NPs). Based on determination metabolites PPA‐NPs, vivo experiments were conducted rats investigate absorption metabolism, antioxidant activity, impact intestinal microbiota PPA‐NPs. UPLC‐Q‐TOF‐MSMS analysis showed that was increased by 220.36% gavaged with PPA‐NPs compared PPA directly. Subsequent revealed significantly bolster primary markers, evidenced elevated glutathione superoxide dismutase levels reduced malondialdehyde content. Moreover, found positively alter microbiome structure aged rats, notably increasing abundance beneficial bacteria, such as Lactobacillus Rothia , improving microbial diversity. These findings suggest markedly PPAs, showcasing promising properties potential health benefits vivo. Overall, research presents a novel approach developing nanodelivery aimed at enhancing water‐soluble substances.
Язык: Английский
Процитировано
2