Chinese Journal of Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 19, 2025
Comprehensive
Summary
The
development
of
photodynamic
therapy
(PDT),
from
its
initial
discovery
effects
to
current
use
in
various
medical
conditions,
is
a
testament
therapeutic
potential.
Recent
breakthroughs
nanotechnology
have
significantly
enhanced
the
effectiveness
PDT.
Typical
nanomaterials
(NMs),
including
metal‐organic
frameworks
(MOFs),
covalent
organic
(COFs),
and
nanozymes
been
introduced
enhance
efficacy
because
they
can
delivery
PSs,
effectively
overcome
insufficient
targeting
specificity,
limited
tissue
penetration
depth,
hypoxic
microenvironments,
thereby
amplifying
efficacy.
However,
clinical
application
these
NMs
PDT
faces
several
challenges,
concerns
regarding
biocompatibility,
long‐term
biosafety,
economic
feasibility.
To
further
advance
PDT,
researchers
should
focus
on
designing
improve
outcomes,
exploring
combination
therapies
with
conducting
translational
trials
validate
safety
novel
approaches.
This
review
summarizes
recent
progress
based
NMs,
especially
MOFs,
COFs
their
disease
treatment.
We
aim
provide
guidance
for
future
research
practice
advancing
NMs‐enhanced
paving
way
more
effective
strategies.
Key
Scientists
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 21, 2024
Natural
products-coordinated
metal
ions
to
form
the
nanomedicines
are
in
spotlight
for
cancer
therapy.
Some
natural
products
could
be
coordinated
with
forming
via
simple
and
green
environmental
self-assembly,
which
not
only
improved
bioavailability
of
products,
but
also
conferred
multiple
therapeutic
modalities
multimodal
imaging.
On
one
hand,
weak
acidity,
glutathione
(GSH)
hydrogen
peroxide
(H2O2)
overexpression
tumor
microenvironment
(TME),
such
carrier-free
further
enhanced
effect
optimizing
species
ions.
other
exert
precise
treatment
under
guidance
Hence,
this
review
summarized
research
progress
recent
years
on
application
product-coordinated
In
addition,
prospects
challenges
were
discussed,
especially
how
improve
targeting
ability
stability
assess
safety
ions,
so
as
facilitate
clinical
translation
nanomedicines.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Tumor
remains
a
leading
contributor
to
global
mortality
rates,
necessitating
urgent
advancements
in
therapeutic
interventions.
Due
the
intricate
nature
of
tumor
microenvironment,
individual
differences
make
it
difficult
achieve
desired
efficacy
with
single
strategy.
To
overcome
these
challenges,
we
develop
for
first
time
hollow
NaBiF4-based
nanocomposites
NaBiF4-W/R-D
therapy
by
glucose
transporter
1
(GLUT1)
inhibition
and
mitochondrial
function
disruption.
can
inhibit
GLUT1
due
presence
WZB117,
which
leads
decrease
intracellular
cells,
leaving
them
starved
state.
Meanwhile,
upconversion
luminescence
under
near-infrared
(NIR)
laser
irradiation
stimulate
photosensitizer
efficiently
generate
singlet
oxygen
disrupt
then
kill
cells.
In
addition,
NIR-II
emission
from
is
used
fluorescence
imaging
determine
optimal
point
treatment.
Finally,
membrane
potential
depolarization,
impaired
function,
activation
caspase-3,
ultimately
amplification
apoptosis.
Abstract
Wound
healing
is
a
dynamic
process
often
accompanied
by
bacterial
infection.
Bacterial
proliferation
and
induced
excessive
inflammation
hinder
the
in
infectious
wounds,
leading
to
refractory
wounds.
Addressing
challenges
of
wounds
requires
development
multifunctional
dressings
capable
eliminating
infection,
relieving
inflammation,
restoring
wound
microenvironment.
In
this
study,
Ag
+
‐ion
functionalized
Cu
2+
UiO‐67
metal‐organic
framework
(MOF‐Ag
MOF‐Cu)
are
incorporated
into
an
oxidized
dextran
gelatin
mixture
fabricate
hydrogel,
termed
as
OGAC.
The
resulting
OGAC
exhibited
injectable,
adhesive,
hemostatic,
antibacterial,
anti‐inflammatory
properties,
along
with
good
biocompatibility.
hydrogel
precursor
could
be
injected
situ
at
site
cover
wound,
serving
physical
barrier
protect
Moreover,
demonstrates
efficient
antibacterial
anti‐biofilm
activity,
against
both
Escherichia
coli
Staphylococcus
aureus
.
Additionally,
has
superoxide
dismutase‐like
glutathione
peroxidase‐like
activity
for
anti‐oxidation,
which
conducive
reduce
wound.
reveals
high
performance
infected
mouse
model.
These
findings
suggest
that
promising
candidate
multiple
functionalities
clinical
management.
Chinese Journal of Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 19, 2025
Comprehensive
Summary
The
development
of
photodynamic
therapy
(PDT),
from
its
initial
discovery
effects
to
current
use
in
various
medical
conditions,
is
a
testament
therapeutic
potential.
Recent
breakthroughs
nanotechnology
have
significantly
enhanced
the
effectiveness
PDT.
Typical
nanomaterials
(NMs),
including
metal‐organic
frameworks
(MOFs),
covalent
organic
(COFs),
and
nanozymes
been
introduced
enhance
efficacy
because
they
can
delivery
PSs,
effectively
overcome
insufficient
targeting
specificity,
limited
tissue
penetration
depth,
hypoxic
microenvironments,
thereby
amplifying
efficacy.
However,
clinical
application
these
NMs
PDT
faces
several
challenges,
concerns
regarding
biocompatibility,
long‐term
biosafety,
economic
feasibility.
To
further
advance
PDT,
researchers
should
focus
on
designing
improve
outcomes,
exploring
combination
therapies
with
conducting
translational
trials
validate
safety
novel
approaches.
This
review
summarizes
recent
progress
based
NMs,
especially
MOFs,
COFs
their
disease
treatment.
We
aim
provide
guidance
for
future
research
practice
advancing
NMs‐enhanced
paving
way
more
effective
strategies.
Key
Scientists
