Clinical and Experimental Medicine,
Год журнала:
2025,
Номер
25(1)
Опубликована: Май 17, 2025
Leukemia,
a
group
of
blood
cancers,
presents
significant
global
health
challenge.
Despite
advancements
in
conventional
therapies
like
chemotherapy
and
immunotherapy,
the
need
for
more
effective
less
toxic
treatments
remains.
Nanotechnology
offers
promising
avenue
targeted
drug
delivery
immune
modulation
fight
against
leukemia.
Through
utilization
nanomaterials'
special
qualities,
their
small
size,
large
surface
area,
capacity
to
transport
variety
payloads,
scientists
are
creating
novel
ways
get
around
drawbacks
treatments.
These
strategies
include
delivery,
cell
activation,
overcoming
resistance.
However,
challenges
remain
translating
these
nanotechnological
approaches
into
clinical
applications.
Addressing
issues
such
as
toxicity,
biodistribution,
regulatory
hurdles
is
crucial
successful
development
nanomedicine
In
conclusion,
nanotechnology
future
treatment
Continued
research
essential
unlock
full
potential
nanomaterials
improve
patient
outcomes.
The
nanotechnology-based
effectiveness
leukemia
explored
this
review.
We
go
over
function
different
delivering
therapeutic
agents
cells,
liposomes,
polymeric
nanoparticles,
inorganic
anoparticles.
also
investigate
engineering
influence
system
promote
anti-tumor
reactions.
Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Авг. 26, 2024
Abstract
CAFs
(cancer-associated
fibroblasts)
are
highly
flexible
cells
of
the
cancer
microenvironment.
They
produce
extracellular
matrix
(ECM)
constituents
that
form
structure
tumor
stroma
but
also
a
source
metabolites,
growth
factors,
chemokines,
and
exosomes
impact
every
aspect
tumor,
including
its
response
to
treatment.
It
is
believed
exosomal
miRNAs
facilitate
intercellular
signaling,
which
essential
for
development
cancer.
The
role
in
microenvironment
(TME)
carcinogenesis
reviewed
this
paper.
preferred
reporting
items
systematic
reviews
meta-analyses
(PRISMA)
2020
guidelines
were
used
perform
review.
Several
databases,
Web
Science,
Medline,
Embase,
Cochrane
Library,
Scopus,
searched
using
following
keywords:
CAFs,
CAF,
cancer-associated
fibroblasts,
stromal
miRNA,
miRNAs,
exosome
similar
terms.
We
identified
studies
investigating
TME
their
carcinogenesis.
A
total
12,572
papers
identified.
After
removing
duplicates
(
n
=
3803),
8774
articles
screened
by
title
abstract.
Of
these,
421
excluded
from
further
analysis.
has
been
reported
if
not
functioning
correctly,
may
influence
secretory
phenotype
tip
contribute
increased
invasiveness,
spread,
decreased
treatment
efficacy,
poorer
prognosis.
Under
influence,
normal
fibroblasts
(NFs)
transformed
into
CAFs.
Furthermore,
they
participate
metabolic
reprogramming,
allows
fast
proliferation
cell
population,
adaptation
growing
energy
demands,
capacity
avoid
immune
system
identification.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 2755 - 2772
Опубликована: Март 1, 2024
Purpose:
The
drug
resistance
and
low
response
rates
of
immunotherapy
limit
its
application.
This
study
aimed
to
construct
a
new
nanoparticle
(CaCO
3
-polydopamine-polyethylenimine,
CPP)
effectively
deliver
interleukin-12
(IL-12)
suppress
cancer
progress
through
immunotherapy.
Methods:
size
distribution
CPP
zeta
potential
were
measured
using
Malvern
Zetasizer
Nano-ZS90.
morphology
electrophoresis
tentative
delay
analyzed
JEM-1400
transmission
electron
microscope
an
ultraviolet
spectrophotometer,
respectively.
Cell
proliferation
was
by
MTT
assay.
Proteins
Western
blot.
IL-12
HMGB1
levels
estimated
ELISA
kits.
Live/dead
staining
assay
performed
Calcein-AM/PI
kit.
ATP
production
detected
xenografts
in
vivo
C57BL/6
mice.
CD80
+
/CD86
,
CD3
/CD4
/CD8
flow
cytometry.
Results:
could
express
EGFP
or
increase
ROS
levels.
Laser
treatment
promoted
CPP-IL-12
induced
the
number
dead
apoptotic
cell.
laser
further
enhance
CALR
extracellular
decrease
intracellular
levels,
indicating
that
it
may
induce
immunogenic
cell
death
(ICD).
tumors
weights
laser-treated
mice
significantly
reduced
than
controls.
expression,
expression
DC
from
lymph
glands,
T
cells
spleen
increased
CPP-IL-12-treated
compared
with
granzyme
B,
IFN-γ,
TNF-α
serum
increased.
Interestingly,
local
back
inhibit
growth
distant
untreated
tumor.
Conclusion:
novel
overexpress
melanoma
achieve
inducing
ICD,
activating
CD4
cell,
enhancing
function
tumor-reactive
CD8
cells.
Keywords:
immunotherapy,
CaCO
nanoparticle,
interleukin-12,
death,
tumor
therapy
iScience,
Год журнала:
2024,
Номер
27(4), С. 109350 - 109350
Опубликована: Фев. 27, 2024
Colorectal
cancer
(CRC)
ranks
as
the
second
leading
cause
of
cancer-related
mortality,
with
metastasis
being
primary
determinant
poor
prognosis
in
patients.
Investigating
molecular
mechanisms
underlying
CRC
is
currently
a
prominent
and
challenging
area
research.
Exosomes,
crucial
intercellular
communication
mediators,
facilitate
transfer
metabolic
genetic
information
from
cells
origin
to
recipient
cells.
Their
roles
mediating
exchange
between
immune
cells,
fibroblasts,
other
cell
types
are
pivotal
reshaping
tumor
microenvironment,
regulating
key
biological
processes
such
invasion,
migration,
formation
pre-metastatic
niche.
This
article
comprehensively
examines
function
mechanism
exosomes
derived
different
metastasis,
while
also
presenting
an
outlook
on
current
research
advancements
future
application
prospects.
The
aim
offer
distinctive
perspective
that
contributes
accurate
diagnosis
rational
treatment
strategies
for
CRC.
Journal of Cancer,
Год журнала:
2024,
Номер
15(11), С. 3510 - 3530
Опубликована: Янв. 1, 2024
Ovarian
cancer
has
the
highest
mortality
among
gynecological
malignancies,
and
exploring
effective
strategies
to
reverse
immunosuppressive
tumor
microenvironment
in
patients
remains
a
pressing
scientific
challenge.
In
this
study,
we
identified
pyroptosis-related
protective
factor,
GBP5,
which
significantly
inhibits
growth
of
ovarian
cells
patient-derived
organoids,
impeding
invasion
migration
cells.
Results
immunohistochemistry
external
single-cell
data
verification
were
consistent.
Further
research
confirmed
that
GBP5
cell
can
induce
canonical
pyroptosis
through
JAK2/STAT1
pathway,
thereby
restraining
progression
cancer.
Interestingly,
also
discovered
with
high
expression
exhibit
increased
expressions
CXCL9/10/11
co-culture
assay.
Subsequent
immune
infiltration
analyses
revealed
remodeling
patients,
characterized
by
polarization
M1
macrophages.
External
immunotherapy
database
analysis
showed
profound
potential
for
application
Overall,
our
study
demonstrates
factor
progression,
triggering
JAK2-STAT1
pathway.
Driven
its
pro-inflammatory
nature,
it
enhance
macrophages
microenvironment,
thus
providing
new
insights
treatment.
Experimental Hematology and Oncology,
Год журнала:
2024,
Номер
13(1)
Опубликована: Май 25, 2024
Abstract
Hematological
malignancies
(HMs)
encompass
a
diverse
group
of
blood
neoplasms
with
significant
morbidity
and
mortality.
Immunotherapy
has
emerged
as
validated
crucial
treatment
modality
for
patients
HMs.
Despite
notable
advancements
having
been
made
in
understanding
implementing
immunotherapy
HMs
over
the
past
decade,
several
challenges
persist.
These
include
immune-related
adverse
effects,
precise
biodistribution
elimination
therapeutic
antigens
vivo,
immune
tolerance
tumors,
evasion
by
tumor
cells
within
microenvironment
(TME).
Nanotechnology,
its
capacity
to
manipulate
material
properties
at
nanometer
scale,
potential
tackle
these
obstacles
revolutionize
outcomes
improving
various
aspects
such
drug
targeting
stability.
The
convergence
nanotechnology
given
rise
nano-immunotherapy,
specialized
branch
anti-tumor
therapy.
Nanotechnology
found
applications
chimeric
antigen
receptor
T
cell
(CAR-T)
therapy,
cancer
vaccines,
checkpoint
inhibitors,
other
immunotherapeutic
strategies
In
this
review,
we
delineate
recent
developments
discuss
current
field
nano-immunotherapy
HMs,
offering
novel
insights
into
nanotechnology-based
approaches
diseases.
Molecular Pharmaceutics,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 3, 2024
Cancer
immunotherapy
is
a
treatment
method
that
activates
or
enhances
the
autoimmune
response
of
body
to
fight
tumor
growth
and
metastasis,
has
fewer
toxic
side
effects
longer-lasting
efficacy
than
radiotherapy
chemotherapy,
become
an
important
means
for
clinical
cancer.
However,
results
from
have
shown
most
patients
lack
responsiveness
cannot
benefit
this
strategy.
The
microenvironment
(TME)
plays
critical
role
in
immunotherapy.
TME
typically
prevents
effective
lymphocyte
activation,
reducing
their
infiltration,
inhibiting
infiltration
effector
T
cells.
According
characteristic
differences
between
normal
tissues,
various
nanoplatforms
with
targeting
regulation
properties
been
developed
more
precise
ability
codeliver
variety
active
pharmaceutical
ingredients,
thereby
systemic
toxicity
improving
therapeutic
effect
antitumor.
In
addition,
structural
design
nanoplatform
can
integrate
specific
functional
motifs,
such
as
surface-targeted
ligands,
degradable
backbones,
stimulus-responsive
components,
into
nanomedicines,
reshaping
microenvironment,
body's
immunosuppressive
state,
enhancing
permeability
drugs
order
achieve
controlled
stimulus-triggered
release
load
cargo.
review,
physiological
characteristics
latest
research
regarding
application
TME-regulated
antitumor
will
be
described.
Furthermore,
existing
problems
further
applications
perspectives
platforms
cancer
also
discussed.
Heliyon,
Год журнала:
2024,
Номер
10(15), С. e34951 - e34951
Опубликована: Июль 21, 2024
Leukemia
is
a
kind
of
hematopoietic
stem
cell
malignant
clonal
disease.
Drug
therapy
the
core
treatment
strategy
for
leukemia,
but
current
therapeutic
drugs
have
defects
such
as
low
bioavailability,
large
adverse
reactions
and
inconvenient
intravenous
administration.
Targeted
can
combine
with
specific
carcinogenic
sites
on
cells
to
kill
cancer
avoid
damage
normal
cells,
which
has
gradually
become
mainstream
method
leukemia
treatment.
In
addition,
nanomedicine
delivery
systems
significantly
improve
drug
efficacy
through
controlled
size
targeted
optimization
by
modification
strategies.
Therefore,
based
nanomaterials
great
research
value
application
prospect.
This
paper
gives
an
overview
strategies
then
reviews
cutting-edge
including
organic
(mainly
carbon-based
nanomaterials,
lipid
materials,
polymers,
etc.)
inorganic
noble
metal
nanoparticles,
magnetic
hollow
mesoporous
etc.).
The
challenges
prospects
future
development
in
are
also
briefly
reviewed.
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(7), С. 7966 - 7977
Опубликована: Апрель 1, 2024
Effective
therapeutic
approaches
against
head
and
neck
squamous
cell
carcinoma
(HNSCC),
which
is
a
prevalent
malignant
tumor,
are
currently
lacking.
Although
immunotherapy
has
emerged
as
promising
strategy
for
treating
HNSCC,
its
efficacy
severely
limited
by
the
immunosuppressive
tumor
microenvironment.
Self-delivery
nanoparticles,
comprising
Toll-like
receptor
(TLR)
agonists
photosensitizers,
were
successfully
developed
to
address
this
challenge
in
combinatorial
HNSCC
treatment.
After
intravenous
administration,
these
nanoparticles
efficiently
accumulated
tumors,
enhancing
bioavailability
of
agonist
triggering
TLR
signaling
pathway
remodel
Simultaneously,
photosensitizers
induced
immunogenic
death
activated
stimulator
interferon
gene
(STING)
cells
via
photodynamic
therapy.
The
development
tumors
was
significantly
inhibited
antitumor
immunity
nanoparticles.
This
study
provided
new
paradigm
immunotherapy,
involving
synergistic
regulation
immune
microenvironment
with
