Micromachines,
Год журнала:
2025,
Номер
16(4), С. 429 - 429
Опубликована: Апрель 2, 2025
Scaffolds
play
a
crucial
role
in
tissue
engineering
as
regenerative
templates.
Fabricating
scaffolds
with
good
biocompatibility
and
appropriate
mechanical
properties
remains
major
challenge
this
field.
This
study
proposes
method
for
preparing
multi-material
scaffolds,
enabling
the
3D
printing
of
collagen
thermoplastic
elastomers
at
room
temperature.
Addressing
previous
challenges
such
poor
printability
pure
difficulty
maintaining
structural
integrity
during
multilayer
printing,
research
improved
by
optimizing
its
concentration
pH
value
completed
large-span
elastomer
using
precise
temperature-control
system.
The
developed
hybrid
scaffold
has
an
interconnected
porous
structure,
which
can
support
adhesion
proliferation
fibroblasts.
were
further
treated
different
post-treatment
methods,
it
was
proven
that
neutralized
cross-linked
scaffold,
both
nano-fibers
certain
rigidity,
better
osteogenic
differentiation
bone
marrow
mesenchymal
stem
cells
(BMSCs).
results
show
significant
clinical
application
potential
soft
hard
regeneration,
providing
versatile
solution
to
meet
diverse
needs
engineering.
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2023,
Номер
42(1)
Опубликована: Дек. 16, 2023
In
vitro
models
are
necessary
to
study
the
pathophysiology
of
disease
and
development
effective,
tailored
treatment
methods
owing
complexity
heterogeneity
breast
cancer
large
population
affected
by
it.
The
cellular
connections
tumor
microenvironments
observed
in
vivo
often
not
recapitulated
conventional
two-dimensional
(2D)
cell
cultures.
Therefore,
developing
3D
that
mimic
complex
architecture
physiological
circumstances
tumors
is
crucial
for
advancing
our
understanding
illness.
A
scaffold-free
model
mimics
allowing
cells
self-assemble/pattern
into
structures,
contrast
with
other
rely
on
artificial
scaffolds.
It
possible
this
model,
whether
applied
using
patient-derived
primary
(fibroblasts,
endothelial
cells,
cells),
can
accurately
replicate
heterogeneity.
complicated
interactions
between
different
types
modelled
integrating
critical
components
microenvironment,
such
as
extracellular
matrix,
vascular
growth
factors.
Tissue
interactions,
immune
infiltration,
effects
milieu
drug
resistance
be
studied
model.
mimicking
a
useful
tool
studying
molecular
basis
disease,
identifying
new
therapeutic
targets,
evaluating
modalities.
provides
more
physiologically
appropriate
high-throughput
platform
screening
compound
library
96-384
well
format.
We
critically
discussed
rapid
personalized
strategies
accelerated
platforms
close
gap
traditional
2D
culture
investigations.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(7), С. 1788 - 1797
Опубликована: Янв. 1, 2024
A
facile
embedded
dot
bioprinting
system
for
bioengineering
desmoplastic
PDAC
spheroids
with
scalable,
flexible
and
robust
performance,
or
multi-type
spheroid
patterns
advanced
drug
therapy
disease
mechanism
exploration,
is
introduced.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 8, 2024
The
complexity
of
tumors
and
the
challenges
associated
with
treatment
often
stem
from
limitations
existing
models
in
accurately
replicating
authentic
tumors.
Recently,
organoid
technology
has
emerged
as
an
innovative
platform
for
tumor
research.
This
bioengineering
approach
enables
researchers
to
simulate,
vitro,
interactions
between
their
microenvironment,
thereby
enhancing
intricate
interplay
cells
surroundings.
Organoids
also
integrate
multidimensional
data,
providing
a
novel
paradigm
understanding
development
progression
while
facilitating
precision
therapy.
Furthermore,
advancements
imaging
genetic
editing
techniques
have
significantly
augmented
potential
organoids
review
explores
application
more
precise
simulations
its
specific
contributions
cancer
research
advancements.
Additionally,
we
discuss
evolving
trends
developing
comprehensive
utilizing
technology.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 8, 2024
Abstract
Organoids,
with
their
capacity
to
mimic
the
structures
and
functions
of
human
organs,
have
gained
significant
attention
for
simulating
pathophysiology
been
extensively
investigated
in
recent
past.
Additionally,
3D
bioprinting,
as
an
emerging
bio‐additive
manufacturing
technology,
offers
potential
constructing
heterogeneous
cellular
microenvironments,
thereby
promoting
advancements
organoid
research.
In
this
review,
latest
developments
bioprinting
technologies
aimed
at
enhancing
engineering
are
introduced.
The
commonly
used
methods
materials
organoids,
a
particular
emphasis
on
advantages
combining
organoids
summarized.
These
include
achieving
high
cell
concentrations
form
large
aggregates,
precise
deposition
building
blocks
create
complex
functions,
automation
throughput
ensure
reproducibility
standardization
culture.
Furthermore,
review
provides
overview
relevant
studies
from
years
discusses
current
limitations
prospects
future
development.
Abstract
Collagen
possesses
high
biocompatibility
with
all
tissue
and
cell
types
in
the
body,
enabling
creation
of
multifunctional
composite
materials
for
medical
applications.
In
biomedical
engineering,
naturally-sourced
collagen
is
often
combined
diverse
organic
inorganic
bioactive
components
to
eliminate
defects
disorders
fields
including
orthopedics,
dermatology,
more.
At
same
time,
medical-related
infection
issues
precise
treatment
needs
patients
require
biomaterials
have
antibacterial
properties
customized
structures.
This
paper
reviews
functionalization
recent
years,
combination
or
agents,
which
beneficial
preventing
controlling
biological
contamination
Then,
existing
problems
future
development
directions
architecturalization
3D
printing
were
discussed,
providing
guidance
personalized
customization
meet
specific
future.
Graphical
Deleted Journal,
Год журнала:
2024,
Номер
3(4), С. 200157 - 200157
Опубликована: Июль 7, 2024
Three-dimensional
(3D)
bioprinting,
which
has
been
applied
in
tissue
engineering
and
regenerative
medicine,
uses
biomaterials,
cells,
other
essential
components
to
manufacture
organs
tissues
with
specific
biological
functions
complex
structures.
Over
the
past
30
years,
researchers
have
developed
new
3D
bioprinting
technologies
improved
manufacturing
capabilities
expanded
applications.
Chinese
research
teams
contributed
significantly
this
process.
In
paper,
we
first
reviewed
development
history
major
milestones
categorizing
them
into
two
main
strategies:
"biomaterial-based
indirect
assembly"
"living
cell-based
direct
assembly".
This
review
further
delved
technical
principles,
recent
advancements,
advantages,
disadvantages,
applications
of
each
type
technology.
Finally,
challenges
future
directions
were
summarized
guide
China
foster
advancements
dynamic
field.
Gels,
Год журнала:
2024,
Номер
10(7), С. 479 - 479
Опубликована: Июль 19, 2024
Breast
cancer
is
the
most
common
malignancy
among
women
and
second
leading
cause
of
cancer-related
death
for
women.
Depending
on
tumor
grade
stage,
breast
primarily
treated
with
surgery
antineoplastic
therapy.
Direct
or
indirect
side
effects,
emotional
trauma,
unpredictable
outcomes
accompany
these
traditional
therapies,
calling
therapies
that
could
improve
overall
treatment
recovery
experiences
patients.
Hydrogels,
biomimetic
materials
3D
network
structures,
have
shown
great
promise
augmenting
Hydrogel
implants
can
be
made
adipogenic
angiogenic
properties
tissue
integration.
organoids
malignant
tumors
grown
in
hydrogels
retain
physical
genetic
characteristics
native
tumors,
allowing
post-surgery
recapitulation
diseased
tissues
precision
medicine
assessment
responsiveness
patient-specific
cancers
to
treatment.
Hydrogels
also
used
as
carrier
matrices
delivering
chemotherapeutics
immunotherapeutics
prosthetic
scaffolds.
The
hydrogel
delivery
systems
achieve
localized
controlled
medication
release
targeting
site,
enhancing
efficacy
minimizing
adverse
effects
therapeutic
agents
delivered
by
procedures.
This
review
aims
summarize
recent
advancements
utilization
reconstruction,
modeling,
therapy
discuss
their
limitations
clinical
translation.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 26, 2024
While
tumor
organoids
have
revolutionized
cancer
research
by
recapitulating
the
cellular
architecture
and
behaviors
of
real
tumors
in
vitro,
their
lack
functional
vasculature
hinders
attainment
full
physiological
capabilities.
Current
efforts
to
vascularize
are
struggling
achieve
well-defined
vascular
networks,
mimicking
intricate
hierarchy
observed
vivo,
which
restricts
relevance
particularly
for
studying
progression
response
therapies
targeting
vasculature.
An
innovative
vascularized
patient-derived
(PDTOs)-on-a-chip
with
hierarchical,
tumor-specific
microvasculature
is
presented,
providing
a
versatile
platform
explore
tumor-vascular
dynamics
antivascular
drug
efficacy.
It
found
that
highly
metastatic
cells
induced
vessel
angiogenesis
simultaneously
migrated
toward
blood
vessels
via
Notch
pathway.
The
evident
association
between
angiogenic
migratory
capacities
PDTOs
clinical
outcomes
underscores
potential
evaluating
metastasis,
thus
offering
valuable
insights
decision-making.
Ultimately,
system
represents
promising
avenue
advancing
understanding
metastasis
developing
personalized
treatment
strategies
based
on
patient-specific
characteristics.
