The
infections
triggered
by
bacteria
often
cause
wound
deterioration,
and
the
development
of
an
alternative,
effective
safe
antimicrobial
treating
system
to
antibiotics
provide
treatment
is
always
highly
desired.
In
this
paper,
lignin-based
nanoenzyme
(SALL)
stably
loading
Ag
nanoparticles
(NPs)
pre-adsorbing
L-arginine
was
constructed
achieve
synergistic
through
chemotherapy
(CT),
chemodynamic
therapy
(CDT),
NO
therapy,
dual
enzymatic
activity
can
respond
pH
difference
between
bacterial
infection
normal
tissues,
efficiently
killing
while
avoiding
oxidative
stress.
Afterwards,
SALL
dispersed
in
eco-friendly
hydrogel
(SALL@K/C)
using
keratin
extracted
from
chicken
feathers
chitosan,
realigned
disulfide
bond
crosslinking
induced
L-cysteine
diverse
intermolecular
interactions,
generated
SALL@K/C
combines
stable
adhesion
injectable
properties
with
capacity,
helping
effects
trapping,
rapid
hemostasis
protection.
microstructure
were
investigated,
mechanisms
achieving
perfect
rheological
antibacterial
revealed.
This
study
used
natural
polymers
construct
bio-friendly
loaded
well-designed
multifunctional
green
excellent
antibacterial,
hemostatic
antiinflammatory
properties,
which
provides
new
ideas
both
for
design
construction
hydrogel.
Journal of Orthopaedic Translation,
Год журнала:
2024,
Номер
47, С. 191 - 206
Опубликована: Июнь 27, 2024
The
regenerative
capacity
of
bone
is
indispensable
for
growth,
given
that
accidental
injury
almost
inevitable.
Bone
relevant
the
aging
population
globally
and
repair
large
defects
after
osteotomy
(e.g.,
following
removal
malignant
tumours).
Among
many
therapeutic
modalities
proposed
to
regeneration,
electrical
stimulation
has
attracted
significant
attention
owing
its
economic
convenience
exceptional
curative
effects,
various
electroactive
biomaterials
have
emerged.
This
review
summarizes
current
knowledge
progress
regarding
strategies
improving
repair.
Such
range
from
traditional
methods
delivering
via
electroconductive
materials
using
external
power
sources
self-powered
biomaterials,
such
as
piezoelectric
nanogenerators.
Electrical
osteogenesis
are
related
piezoelectricity.
examines
cell
behaviour
potential
mechanisms
electrostimulation
in
healing,
aiming
provide
new
insights
regeneration
biomaterials.
roles
rehabilitating
microenvironment
facilitate
addressing
whereby
cues
mediate
regeneration.
Interactions
between
osteogenesis-related
cells
summarized,
leading
proposals
use
stimulation-based
therapies
accelerate
healing.
Abstract
3D
printing
is
now
recognized
as
a
significant
tool
for
medical
research
and
clinical
practice,
leading
to
the
emergence
of
technology.
It
essential
improve
properties
3D‐printed
products
meet
demand
use.
The
core
generating
qualified
develop
advanced
materials
processes.
Taking
advantage
nanomaterials
with
tunable
distinct
physical,
chemical,
biological
properties,
integrating
nanotechnology
into
creates
new
opportunities
advancing
field.
Recently,
some
attempts
are
made
through
nanotechnology,
providing
insights
developing
With
high‐resolution
technology,
nano‐structures
can
be
directly
fabricated
applications.
Incorporating
material
system
products.
At
same
time,
used
expand
novel
technologies.
This
review
introduced
strategies
progresses
improving
discussed
challenges
in
translation.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(13)
Опубликована: Фев. 11, 2024
Abstract
Hydrogel
is
a
very
promising
dressing
for
hemostasis
and
wound
healing
due
to
its
good
adhesion
long‐term
moist
environment.
However,
secondary
injury
caused
by
tissue
homogeneous
hydrogel
cannot
be
ignored.
The
obvious
interface
existing
in
Janus
will
weaken
asymmetric
function.
Here,
hierarchical
adhesive
polyacrylic
acid–polyurushiol
water–oil
(JPs@PAA‐PU)
without
layer
fabricated
one‐pot
method
the
stabilization
of
polystyrene@silica‐siliver
particles
(JPs).
morphological
structure,
mechanical
properties,
anisotropic
chemical
composition,
performance,
vivo,
vitro
hemostatic
properties
are
investigated.
Result
shows
that
obtained
possesses
compartmentalization
microstructure,
functional
groups,
elements.
provided
with
interfacial
toughness
top
52.45
±
2.29
Kpa
bottom
7.04
0.88
on
porcine
liver.
PAA
side
tissue,
red
blood
cells
platelets,
promoting
effect
PU
coagulation
cascade
reaction
physical
battier
endow
shorter
time
less
loss
than
control
group.
It
also
exhibits
excellent
antibacterial
effects
against
Escherichia
coli
Staphylococcus
aureus
(>90%).
biosafety,
providing
safety
guarantee
clinical
applications
future.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(18), С. 4489 - 4501
Опубликована: Янв. 1, 2024
Laser-assisted
surface
alloying
(LSA)
process
to
modify
orthopedic
implant
surfaces
with
Ti–Ag
alloy
for
enhanced
antibacterial
and
osteoinduction
properties.
ACS Omega,
Год журнала:
2025,
Номер
10(2), С. 1911 - 1926
Опубликована: Янв. 10, 2025
Incorporating
zinc
into
biocompatible
materials
has
been
identified
as
a
potential
strategy
for
promoting
bone
regeneration
and
osteogenic
activity
during
hard
tissue
regeneration.
This
work
aimed
to
investigate
the
impact
of
doping
on
structure
akermanite,
which
was
synthesized
using
sol–gel
combustion
method,
with
goal
improving
biological
response.
Powder
XRD
FT-IR
analysis
confirmed
phase
purity
respective
functional
groups
associated
Zn-doped
akermanite.
Further
XPS
presence
binding
energies
in
akermanite
matrix.
According
results
obtained
from
analysis,
apatite-forming
ability
demonstrated
enhanced
apatite
deposition
surface
pellet
after
9
days
immersion
SBF
medium.
The
measured
mechanical
parameters,
including
compressive
strength
(140–189
MPa)
Young's
modulus
(2505–3599
MPa),
fall
within
range
human
cortical
bone.
Antimicrobial
showed
an
improved
inhibition
rate
doped
ceramics
compared
pure
percentage
87%
even
at
lower
concentrations.
hemocompatibility
hemolysis
blood
cells
acceptable
without
exhibiting
toxicity.
Cytotoxicity
demonstrate
biocompatibility
MG-63
cell
line.
Based
results,
optimal
concentrations
found
be
compatible
nontoxic
it
alternative
orthopedic
applications.
Macromolecular Rapid Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Abstract
Myocardial
infarction
(MI)
is
a
leading
cause
of
mortality
among
cardiovascular
diseases.
Following
MI,
the
damaged
myocardium
progressively
being
replaced
by
fibrous
scar
tissue,
which
exhibits
poor
electrical
conductivity,
ultimately
resulting
in
arrhythmias
and
adverse
cardiac
remodeling.
Due
to
their
extracellular
matrix‐like
structure
excellent
biocompatibility,
hydrogels
are
emerging
as
focal
point
tissue
engineering.
However,
traditional
lack
necessary
conductivity
restore
signal
transmission
infarcted
regions.
Imparting
while
also
enhancing
adhesive
properties
enables
them
adhere
closely
myocardial
establish
stable
connections,
facilitate
synchronized
contraction
repair
within
area.
This
paper
reviews
strategies
for
constructing
conductive
hydrogels,
focusing
on
application
MI
repair.
Furthermore,
challenges
future
directions
developing
discussed.
