Silver phosphate-modified carbonate apatite honeycomb scaffolds for anti-infective and pigmentation-free bone tissue engineering

Materials Today Bio, Год журнала: 2024, Номер 27, С. 101161 - 101161

Опубликована: Июль 18, 2024

Bone regeneration using synthetic materials has a high rate of surgical site infection, resulting in severe pain for patients and often requiring revision surgery. We propose Ag

Язык: Английский

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Dual-functional composite hydrogel platform: A “kill two birds with one stone” strategy for anti-infection and osseointegration in the treatment of infectious bone defects

Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155337 - 155337

Опубликована: Сен. 1, 2024

Infectious bone defect (IBD), caused by various factors, frequently recur and are challenging to cure. Current treatments predominantly rely on a combination of antibiotics traditional surgery, yet they have not significantly reduced long-term recurrence rates. Given the complex microenvironment persistent mechanisms mediated bacteria, it is crucial for implants enhance osseointegration while ensuring sustained effective infection control. Hydrogels emerged as promising solution in tissue engineering due their excellent drug-loading efficiency, controlled drug release, adjustable mechanical strength, biocompatibility. Over past decade, hydrogels with dual anti-infection pro-osseointegration functions demonstrated efficacy treating IBD, making clinical application possible. This review summarizes current highlighting pros cons infection-mediated immune microenvironments. Additionally, discusses essential physicochemical properties suitable IBD reviews latest advancements dual-functional hydrogels. Finally, addresses future prospects, technical challenges, unresolved issues development Overall, this aims facilitate advancement implementation tailored therapeutic needs IBD.

Язык: Английский

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Zinc Doped Akermanite: A Promising Biomaterial for Orthopedic Application with Enhanced Bioactivity, Mechanical Strength, and Bacterial Study

ACS Omega, Год журнала: 2025, Номер 10(2), С. 1911 - 1926

Опубликована: Янв. 10, 2025

Incorporating zinc into biocompatible materials has been identified as a potential strategy for promoting bone regeneration and osteogenic activity during hard tissue regeneration. This work aimed to investigate the impact of doping on structure akermanite, which was synthesized using sol–gel combustion method, with goal improving biological response. Powder XRD FT-IR analysis confirmed phase purity respective functional groups associated Zn-doped akermanite. Further XPS presence binding energies in akermanite matrix. According results obtained from analysis, apatite-forming ability demonstrated enhanced apatite deposition surface pellet after 9 days immersion SBF medium. The measured mechanical parameters, including compressive strength (140–189 MPa) Young's modulus (2505–3599 MPa), fall within range human cortical bone. Antimicrobial showed an improved inhibition rate doped ceramics compared pure percentage 87% even at lower concentrations. hemocompatibility hemolysis blood cells acceptable without exhibiting toxicity. Cytotoxicity demonstrate biocompatibility MG-63 cell line. Based results, optimal concentrations found be compatible nontoxic it alternative orthopedic applications.

Язык: Английский

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Adhesive and Conductive Hydrogels for the Treatment of Myocardial Infarction

Macromolecular Rapid Communications, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Abstract Myocardial infarction (MI) is a leading cause of mortality among cardiovascular diseases. Following MI, the damaged myocardium progressively being replaced by fibrous scar tissue, which exhibits poor electrical conductivity, ultimately resulting in arrhythmias and adverse cardiac remodeling. Due to their extracellular matrix‐like structure excellent biocompatibility, hydrogels are emerging as focal point tissue engineering. However, traditional lack necessary conductivity restore signal transmission infarcted regions. Imparting while also enhancing adhesive properties enables them adhere closely myocardial establish stable connections, facilitate synchronized contraction repair within area. This paper reviews strategies for constructing conductive hydrogels, focusing on application MI repair. Furthermore, challenges future directions developing discussed.

Язык: Английский

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Recent development in polymer nanocomposites for biomedical and antibacterial applications

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 585 - 656

Опубликована: Янв. 1, 2025

Язык: Английский

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Lignin-based nanoenzyme doped hydrogel for NO-enhanced chemodynamic therapy of bacterial infections

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 302, С. 140489 - 140489

Опубликована: Янв. 29, 2025

Язык: Английский

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In vitro bioactivity, cytotoxicity, and antibacterial property of spray-dried Ag-doped mesoporous bioactive glass microspheres with different Ag precursor treatment

Ceramics International, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Recent advances and challenges in metal-based antimicrobial materials: a review of strategies to combat antibiotic resistance

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 9, 2025

Despite the availability of a series classical antibiotic drugs, bacterial infections continue to represent significant and urgent threat global human health. The emergence drug-resistant bacteria slow pace development have rendered current treatment methods inadequate in meeting clinical demands infections. Consequently, there is an increasingly vital need for safe, efficient, alternative novel antimicrobial agents medical healthcare field. Over past five years, has been notable expansion field nanomedicine with regard prevention control infectious diseases. objective this article provide comprehensive review latest research developments metal nanomaterials therapy. We begin by delineating gravity infection crisis, subsequently undertaking examination potential mechanisms through which nanoparticles may combat specific applications these diverse In conclusion, we eagerly anticipate future directions believe that continuous technological advancements innovations, will make even more outstanding contributions safeguarding health well-being.

Язык: Английский

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Bone formation and bioresorption of silver-doped β-tricalcium phosphate in rabbit bone defects

Journal of Applied Biomaterials & Functional Materials, Год журнала: 2025, Номер 23

Опубликована: Апрель 1, 2025

Implant-associated infections pose a significant challenge in orthopedic surgery but may be prevented using biomaterials containing antimicrobial agents such as Ag ions. This study examines the effects of doping on bone metabolism following implantation β-tricalcium phosphate (β-TCP) doped with 0, 1, 3, and 5 at% 75% porosity. Additionally, activity Ag-doped β-TCP was evaluated against Staphylococcus aureus Escherichia coli shake flask tests, revealing increased higher concentrations. Cylindrical defects (diameter 4 mm; depth 10 mm) were introduced lateral femoral condyles rabbits treated β-TCP. The euthanized at 2-, 4-, 8-, 12-weeks post-operation ( n = 6/time point). Specimens decalcified for histological examination optical scanning electron microscopy (SEM). Bone formation, residual material, tartrate-resistant acid phosphatase (TRAP)-positive cell counts quantified, statistical significance assessed one-way ANOVA p < 0.05). formation over time up to 12 weeks lower Residual material decreased, while TRAP-positive cells peaked 2 gradually declined thereafter. SEM revealed accumulation marrow outside newly formed bone. inhibited resorption more than osteogenesis. defect area delayed concentration increased, likely due reduced osteoclast activity. highlights dual effect implant-associated infections. While incorporation enhanced potential, concentrations metabolism. Optimizing content is crucial balancing infection control effective regeneration, guiding development advanced implants.

Язык: Английский

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Bioinspired Amine-Guided Polyphenol Coatings for Selective Bacterial Disruption and Osseointegration on Orthopedic Implants

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

Implant-related infections and inadequate osseointegration pose significant challenges in orthopedic surgery. However, current surface modification strategies are generally complex or necessitate harsh synthesis conditions, thereby limiting their versatility. We developed a facile, one-step method to fabricate stable polyphenol-based coating on titanium using amine-directed self-polymerization. Amine forms covalent bonds with polyphenol, enhancing the stability, as confirmed by molecular dynamics simulations. This bioinspired eliminated over 90% of Staphylococcus aureus Escherichia coli disrupting bacterial chemotaxis FTSI protein expression cell wall, impairing respiration interfering proton electron transfer membranes, which could selectively eliminate pathogenic bacteria through contact-killing mechanism without any negative effect mammalian cells. It also promoted growth differentiation bone mesenchymal cells via Wnt/β-catenin pathway. Additionally, The modulated macrophages toward pro-repair M2 polarization. In cell-bacteria competitive coculture experiments, exhibited superior antibacterial efficacy. vivo studies demonstrate 50% improvement infected models. approach is versatile can be applied various implant materials, offering scalable solution for next-generation medical devices.

Язык: Английский

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