Metals,
Год журнала:
2024,
Номер
14(8), С. 901 - 901
Опубликована: Авг. 8, 2024
Ti-13Nb-13Zr-7Ag
(TNZ-7Ag)
has
a
great
potential
for
biomedical
application
due
to
its
low
elastic
modulus
and
excellent
antibacterial
properties.
However,
it
is
difficult
balance
high
In
this
study,
the
TNZ-7Ag
was
treated
by
pre-deformation
aging
treatment
avoid
problem.
The
results
proved
that
stress-induced
twinning
caused
large
range
of
Ti2Ag
particle
agglomeration,
in
turn
enhanced
performance
Ag-containing
titanium
alloys.
And
twinned
martensite
formed
during
promoted
precipitation
phase
inhibited
growth
α
phase.
As
result,
with
both
strong
properties
obtained
treatments.
All
demonstrated
based
on
synergistic
effect
an
effective
strategy
develop
novel
Low-elastic-modulus
alloys,
which
can
be
used
development
were
prepared.
Materials Today Bio,
Год журнала:
2024,
Номер
27, С. 101161 - 101161
Опубликована: Июль 18, 2024
Bone
regeneration
using
synthetic
materials
has
a
high
rate
of
surgical
site
infection,
resulting
in
severe
pain
for
patients
and
often
requiring
revision
surgery.
We
propose
Ag
Chemical Engineering Journal,
Год журнала:
2024,
Номер
498, С. 155337 - 155337
Опубликована: Сен. 1, 2024
Infectious
bone
defect
(IBD),
caused
by
various
factors,
frequently
recur
and
are
challenging
to
cure.
Current
treatments
predominantly
rely
on
a
combination
of
antibiotics
traditional
surgery,
yet
they
have
not
significantly
reduced
long-term
recurrence
rates.
Given
the
complex
microenvironment
persistent
mechanisms
mediated
bacteria,
it
is
crucial
for
implants
enhance
osseointegration
while
ensuring
sustained
effective
infection
control.
Hydrogels
emerged
as
promising
solution
in
tissue
engineering
due
their
excellent
drug-loading
efficiency,
controlled
drug
release,
adjustable
mechanical
strength,
biocompatibility.
Over
past
decade,
hydrogels
with
dual
anti-infection
pro-osseointegration
functions
demonstrated
efficacy
treating
IBD,
making
clinical
application
possible.
This
review
summarizes
current
highlighting
pros
cons
infection-mediated
immune
microenvironments.
Additionally,
discusses
essential
physicochemical
properties
suitable
IBD
reviews
latest
advancements
dual-functional
hydrogels.
Finally,
addresses
future
prospects,
technical
challenges,
unresolved
issues
development
Overall,
this
aims
facilitate
advancement
implementation
tailored
therapeutic
needs
IBD.
ACS Omega,
Год журнала:
2025,
Номер
10(2), С. 1911 - 1926
Опубликована: Янв. 10, 2025
Incorporating
zinc
into
biocompatible
materials
has
been
identified
as
a
potential
strategy
for
promoting
bone
regeneration
and
osteogenic
activity
during
hard
tissue
regeneration.
This
work
aimed
to
investigate
the
impact
of
doping
on
structure
akermanite,
which
was
synthesized
using
sol–gel
combustion
method,
with
goal
improving
biological
response.
Powder
XRD
FT-IR
analysis
confirmed
phase
purity
respective
functional
groups
associated
Zn-doped
akermanite.
Further
XPS
presence
binding
energies
in
akermanite
matrix.
According
results
obtained
from
analysis,
apatite-forming
ability
demonstrated
enhanced
apatite
deposition
surface
pellet
after
9
days
immersion
SBF
medium.
The
measured
mechanical
parameters,
including
compressive
strength
(140–189
MPa)
Young's
modulus
(2505–3599
MPa),
fall
within
range
human
cortical
bone.
Antimicrobial
showed
an
improved
inhibition
rate
doped
ceramics
compared
pure
percentage
87%
even
at
lower
concentrations.
hemocompatibility
hemolysis
blood
cells
acceptable
without
exhibiting
toxicity.
Cytotoxicity
demonstrate
biocompatibility
MG-63
cell
line.
Based
results,
optimal
concentrations
found
be
compatible
nontoxic
it
alternative
orthopedic
applications.
Macromolecular Rapid Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Abstract
Myocardial
infarction
(MI)
is
a
leading
cause
of
mortality
among
cardiovascular
diseases.
Following
MI,
the
damaged
myocardium
progressively
being
replaced
by
fibrous
scar
tissue,
which
exhibits
poor
electrical
conductivity,
ultimately
resulting
in
arrhythmias
and
adverse
cardiac
remodeling.
Due
to
their
extracellular
matrix‐like
structure
excellent
biocompatibility,
hydrogels
are
emerging
as
focal
point
tissue
engineering.
However,
traditional
lack
necessary
conductivity
restore
signal
transmission
infarcted
regions.
Imparting
while
also
enhancing
adhesive
properties
enables
them
adhere
closely
myocardial
establish
stable
connections,
facilitate
synchronized
contraction
repair
within
area.
This
paper
reviews
strategies
for
constructing
conductive
hydrogels,
focusing
on
application
MI
repair.
Furthermore,
challenges
future
directions
developing
discussed.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 9, 2025
Despite
the
availability
of
a
series
classical
antibiotic
drugs,
bacterial
infections
continue
to
represent
significant
and
urgent
threat
global
human
health.
The
emergence
drug-resistant
bacteria
slow
pace
development
have
rendered
current
treatment
methods
inadequate
in
meeting
clinical
demands
infections.
Consequently,
there
is
an
increasingly
vital
need
for
safe,
efficient,
alternative
novel
antimicrobial
agents
medical
healthcare
field.
Over
past
five
years,
has
been
notable
expansion
field
nanomedicine
with
regard
prevention
control
infectious
diseases.
objective
this
article
provide
comprehensive
review
latest
research
developments
metal
nanomaterials
therapy.
We
begin
by
delineating
gravity
infection
crisis,
subsequently
undertaking
examination
potential
mechanisms
through
which
nanoparticles
may
combat
specific
applications
these
diverse
In
conclusion,
we
eagerly
anticipate
future
directions
believe
that
continuous
technological
advancements
innovations,
will
make
even
more
outstanding
contributions
safeguarding
health
well-being.
Journal of Applied Biomaterials & Functional Materials,
Год журнала:
2025,
Номер
23
Опубликована: Апрель 1, 2025
Implant-associated
infections
pose
a
significant
challenge
in
orthopedic
surgery
but
may
be
prevented
using
biomaterials
containing
antimicrobial
agents
such
as
Ag
ions.
This
study
examines
the
effects
of
doping
on
bone
metabolism
following
implantation
β-tricalcium
phosphate
(β-TCP)
doped
with
0,
1,
3,
and
5
at%
75%
porosity.
Additionally,
activity
Ag-doped
β-TCP
was
evaluated
against
Staphylococcus
aureus
Escherichia
coli
shake
flask
tests,
revealing
increased
higher
concentrations.
Cylindrical
defects
(diameter
4
mm;
depth
10
mm)
were
introduced
lateral
femoral
condyles
rabbits
treated
β-TCP.
The
euthanized
at
2-,
4-,
8-,
12-weeks
post-operation
(
n
=
6/time
point).
Specimens
decalcified
for
histological
examination
optical
scanning
electron
microscopy
(SEM).
Bone
formation,
residual
material,
tartrate-resistant
acid
phosphatase
(TRAP)-positive
cell
counts
quantified,
statistical
significance
assessed
one-way
ANOVA
p
<
0.05).
formation
over
time
up
to
12
weeks
lower
Residual
material
decreased,
while
TRAP-positive
cells
peaked
2
gradually
declined
thereafter.
SEM
revealed
accumulation
marrow
outside
newly
formed
bone.
inhibited
resorption
more
than
osteogenesis.
defect
area
delayed
concentration
increased,
likely
due
reduced
osteoclast
activity.
highlights
dual
effect
implant-associated
infections.
While
incorporation
enhanced
potential,
concentrations
metabolism.
Optimizing
content
is
crucial
balancing
infection
control
effective
regeneration,
guiding
development
advanced
implants.
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 29, 2025
Implant-related
infections
and
inadequate
osseointegration
pose
significant
challenges
in
orthopedic
surgery.
However,
current
surface
modification
strategies
are
generally
complex
or
necessitate
harsh
synthesis
conditions,
thereby
limiting
their
versatility.
We
developed
a
facile,
one-step
method
to
fabricate
stable
polyphenol-based
coating
on
titanium
using
amine-directed
self-polymerization.
Amine
forms
covalent
bonds
with
polyphenol,
enhancing
the
stability,
as
confirmed
by
molecular
dynamics
simulations.
This
bioinspired
eliminated
over
90%
of
Staphylococcus
aureus
Escherichia
coli
disrupting
bacterial
chemotaxis
FTSI
protein
expression
cell
wall,
impairing
respiration
interfering
proton
electron
transfer
membranes,
which
could
selectively
eliminate
pathogenic
bacteria
through
contact-killing
mechanism
without
any
negative
effect
mammalian
cells.
It
also
promoted
growth
differentiation
bone
mesenchymal
cells
via
Wnt/β-catenin
pathway.
Additionally,
The
modulated
macrophages
toward
pro-repair
M2
polarization.
In
cell-bacteria
competitive
coculture
experiments,
exhibited
superior
antibacterial
efficacy.
vivo
studies
demonstrate
50%
improvement
infected
models.
approach
is
versatile
can
be
applied
various
implant
materials,
offering
scalable
solution
for
next-generation
medical
devices.