The
infections
triggered
by
bacteria
often
cause
wound
deterioration,
and
the
development
of
an
alternative,
effective
safe
antimicrobial
treating
system
to
antibiotics
provide
treatment
is
always
highly
desired.
In
this
paper,
lignin-based
nanoenzyme
(SALL)
stably
loading
Ag
nanoparticles
(NPs)
pre-adsorbing
L-arginine
was
constructed
achieve
synergistic
through
chemotherapy
(CT),
chemodynamic
therapy
(CDT),
NO
therapy,
dual
enzymatic
activity
can
respond
pH
difference
between
bacterial
infection
normal
tissues,
efficiently
killing
while
avoiding
oxidative
stress.
Afterwards,
SALL
dispersed
in
eco-friendly
hydrogel
(SALL@K/C)
using
keratin
extracted
from
chicken
feathers
chitosan,
realigned
disulfide
bond
crosslinking
induced
L-cysteine
diverse
intermolecular
interactions,
generated
SALL@K/C
combines
stable
adhesion
injectable
properties
with
capacity,
helping
effects
trapping,
rapid
hemostasis
protection.
microstructure
were
investigated,
mechanisms
achieving
perfect
rheological
antibacterial
revealed.
This
study
used
natural
polymers
construct
bio-friendly
loaded
well-designed
multifunctional
green
excellent
antibacterial,
hemostatic
antiinflammatory
properties,
which
provides
new
ideas
both
for
design
construction
hydrogel.
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Год журнала:
2025,
Номер
167, С. 106963 - 106963
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 9, 2025
Despite
the
availability
of
a
series
classical
antibiotic
drugs,
bacterial
infections
continue
to
represent
significant
and
urgent
threat
global
human
health.
The
emergence
drug-resistant
bacteria
slow
pace
development
have
rendered
current
treatment
methods
inadequate
in
meeting
clinical
demands
infections.
Consequently,
there
is
an
increasingly
vital
need
for
safe,
efficient,
alternative
novel
antimicrobial
agents
medical
healthcare
field.
Over
past
five
years,
has
been
notable
expansion
field
nanomedicine
with
regard
prevention
control
infectious
diseases.
objective
this
article
provide
comprehensive
review
latest
research
developments
metal
nanomaterials
therapy.
We
begin
by
delineating
gravity
infection
crisis,
subsequently
undertaking
examination
potential
mechanisms
through
which
nanoparticles
may
combat
specific
applications
these
diverse
In
conclusion,
we
eagerly
anticipate
future
directions
believe
that
continuous
technological
advancements
innovations,
will
make
even
more
outstanding
contributions
safeguarding
health
well-being.
Journal of Applied Biomaterials & Functional Materials,
Год журнала:
2025,
Номер
23
Опубликована: Апрель 1, 2025
Implant-associated
infections
pose
a
significant
challenge
in
orthopedic
surgery
but
may
be
prevented
using
biomaterials
containing
antimicrobial
agents
such
as
Ag
ions.
This
study
examines
the
effects
of
doping
on
bone
metabolism
following
implantation
β-tricalcium
phosphate
(β-TCP)
doped
with
0,
1,
3,
and
5
at%
75%
porosity.
Additionally,
activity
Ag-doped
β-TCP
was
evaluated
against
Staphylococcus
aureus
Escherichia
coli
shake
flask
tests,
revealing
increased
higher
concentrations.
Cylindrical
defects
(diameter
4
mm;
depth
10
mm)
were
introduced
lateral
femoral
condyles
rabbits
treated
β-TCP.
The
euthanized
at
2-,
4-,
8-,
12-weeks
post-operation
(
n
=
6/time
point).
Specimens
decalcified
for
histological
examination
optical
scanning
electron
microscopy
(SEM).
Bone
formation,
residual
material,
tartrate-resistant
acid
phosphatase
(TRAP)-positive
cell
counts
quantified,
statistical
significance
assessed
one-way
ANOVA
p
<
0.05).
formation
over
time
up
to
12
weeks
lower
Residual
material
decreased,
while
TRAP-positive
cells
peaked
2
gradually
declined
thereafter.
SEM
revealed
accumulation
marrow
outside
newly
formed
bone.
inhibited
resorption
more
than
osteogenesis.
defect
area
delayed
concentration
increased,
likely
due
reduced
osteoclast
activity.
highlights
dual
effect
implant-associated
infections.
While
incorporation
enhanced
potential,
concentrations
metabolism.
Optimizing
content
is
crucial
balancing
infection
control
effective
regeneration,
guiding
development
advanced
implants.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(14)
Опубликована: Фев. 16, 2024
The
presence
of
multidrug-resistant
bacteria
has
challenged
the
clinical
treatment
bacterial
infection.
There
is
a
real
need
for
development
novel
biocompatible
materials
with
broad-spectrum
antimicrobial
activities.
Antimicrobial
hydrogels
show
great
potential
in
infected
wound
healing
but
are
still
being
challenged.
Herein,
antibacterial
and
mechanically
tunable
amyloid-based
based
on
self-assembly
local
mineralization
silver
nanoparticles
reported.
mineralized
have
advantages
sustained
release
silver,
prolonged
effect,
improved
adhesion
capacity.
Moreover,
display
significant
effect
against
both
Gram-positive
Gram-negative
cells
mice
by
inducing
membrane
damage
reactive
oxygen
species
toxicity
bacteria.
In
addition,
can
rapidly
accelerate
synergy
between
their
activity
intrinsic
improvement
cell
proliferation
migration.
This
study
provides
modular
approach
to
developing
multifunctional
protein
hydrogel
platform
biomolecule-coordinated
wide
range
biomedical
applications.
Materials Today Bio,
Год журнала:
2024,
Номер
27, С. 101161 - 101161
Опубликована: Июль 18, 2024
Bone
regeneration
using
synthetic
materials
has
a
high
rate
of
surgical
site
infection,
resulting
in
severe
pain
for
patients
and
often
requiring
revision
surgery.
We
propose
Ag
Chemical Engineering Journal,
Год журнала:
2024,
Номер
498, С. 155337 - 155337
Опубликована: Сен. 1, 2024
Infectious
bone
defect
(IBD),
caused
by
various
factors,
frequently
recur
and
are
challenging
to
cure.
Current
treatments
predominantly
rely
on
a
combination
of
antibiotics
traditional
surgery,
yet
they
have
not
significantly
reduced
long-term
recurrence
rates.
Given
the
complex
microenvironment
persistent
mechanisms
mediated
bacteria,
it
is
crucial
for
implants
enhance
osseointegration
while
ensuring
sustained
effective
infection
control.
Hydrogels
emerged
as
promising
solution
in
tissue
engineering
due
their
excellent
drug-loading
efficiency,
controlled
drug
release,
adjustable
mechanical
strength,
biocompatibility.
Over
past
decade,
hydrogels
with
dual
anti-infection
pro-osseointegration
functions
demonstrated
efficacy
treating
IBD,
making
clinical
application
possible.
This
review
summarizes
current
highlighting
pros
cons
infection-mediated
immune
microenvironments.
Additionally,
discusses
essential
physicochemical
properties
suitable
IBD
reviews
latest
advancements
dual-functional
hydrogels.
Finally,
addresses
future
prospects,
technical
challenges,
unresolved
issues
development
Overall,
this
aims
facilitate
advancement
implementation
tailored
therapeutic
needs
IBD.
