European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 279, С. 116909 - 116909
Опубликована: Сен. 24, 2024
Язык: Английский
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Сен. 5, 2024
Abstract Utilizing enzyme cascades as a promising approach for targeted cancer therapies holds significant potential, yet its clinical effectiveness is substantially hindered by functional losses during delivery. Complex coacervation emerges an intriguing strategy designing nanoreactors. In this study, noteworthy achievement presented in the development of lactobionic acid‐modified tumor microenvironment (TME)‐responsive polyelectrolyte complex vesicles (HGS‐PCVs) based on bioinspired homopolypeptoids, which serve facile, intelligent, and highly efficient nanoreactor tunable glucose oxidase, hemoglobin, sorafenib (SRF) to hepatic cells. The TME‐responsive permeability HGS‐PCVs enables selective entry into their interior, triggering enzymatic cascade reaction within tumor. This intricate process generates toxic hydroxyl radicals while concurrently lowering pH. Consequently, pH shift enhances SRF release, effectively promoting ferroptosis apoptosis target Further, administration not only initiates immunogenic cell death but also plays crucial role inducing maturation dendritic cells lymph nodes. It stimulates adaptive T‐cell response, mechanism that contributes impeding growth distant tumors vivo, demonstrating potential PCVs immunotherapy.
Язык: Английский
Процитировано
5
Journal of Gastroenterology, Год журнала: 2023, Номер 59(2), С. 81 - 94
Опубликована: Ноя. 10, 2023
Язык: Английский
Процитировано
11
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Июнь 19, 2024
Ferroptosis is a form of regulated cell death (RCD) characterized by iron-dependent lipid peroxidation. currently proposed as one the most promising means combating tumor resistance. Nevertheless, problem ferroptosis resistance in certain cancer cells has been identified. This review first, investigates mechanisms induction cells. Next, to ferroptosis, well underlying discussed. Recently discovered ferroptosis-suppressing biomarkers have described. The various types nanoparticles that can induce are also Given ability combine multiple agents, this proposes nanoparticle-based viable method circumventing suggests combining with other forms death, such apoptosis, cuproptosis and autophagy. It immunotherapy.
Язык: Английский
Процитировано
4
Bioactive Materials, Год журнала: 2024, Номер 44, С. 488 - 500
Опубликована: Ноя. 5, 2024
Язык: Английский
Процитировано
4
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Янв. 24, 2025
Breast cancer utilizes diverse immunosuppressive mechanisms to evade immune surveillance, thereby impairing immunotherapeutic effects. In this work, a chimeric peptide functionalized immunostimulant (designated as aGlyR) is fabricated boost photodynamic immunotherapy through PD-L1 deglycosylation and CD47 inhibition. The photosensitizer protoporphyrin IX (PpIX) conjugated via hydrophilic PEG8 linker, yielding the Fmoc-K(PpIX)-PEG8-GFTATPPAPDSPQEP. This could self-assemble into nanomicelles capable of encapsulating inhibitor RRx-001, generating multifunctional aGlyR. vitro in vivo results indicate that therapy (PDT) aGlyR disrupt breast cells trigger immunogenic cell death (ICD), leading release tumor-associated antigens (TAAs) activation immunological cascades. Additionally, component degradation PD-L1, which restores T cell-mediated activity. Concurrently, RRx-001 blocks pathway, disrupting antiphagocytic signaling activating innate responses. synergistic immunomodulatory approach effectively reverses complex factors, significantly enhancing effects conventional treatments.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160231 - 160231
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Март 27, 2025
Abstract Immune evasion and metastasis are the leading causes of poor prognosis in triple‐negative breast cancer treatment. Since current standard immunotherapies have limited efficacy due to immunologically cold microenvironment, it is crucial explore new strategies sensitize anticancer immune response. In this study, found that incorporating β ‐lapachone‐based oxidation therapy with CUDC101‐initiated epigenetic regulation results synergistic antitumor effects potent activation. To co‐deliver these two hydrophobic drugs, IR783 cyanine structure serves as stabilizer form a nanoformulation based on small molecule self‐assembly. Such IR783‐stabilized nanodrugs can not only lead cell apoptosis through HDAC inhibition‐enhanced but also cooperatively induce immunogenic death promote pro‐inflammatory cytokine gene expression reshape immunosuppressive microenvironment. Besides, inhibit both primary distant tumor growth effectively by elevating systemic immunity. This study provides promising approach synergize modulation for safe efficient immunotherapy.
Язык: Английский
Процитировано
0
Chemical Society Reviews, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Light serves as an excellent external stimulus due to its high spatial and temporal resolution. The use of light regulate biological processes has evolved into a vibrant field over the past decade. Employing on chemical substances such bioactive molecules drug delivery systems offers promising therapeutic approach achieve precise control processes. In this review, we provide overview advancements in optochemical technologies for controlling (photopharmacology) (photoresponsive delivery), with emphasis their relationship biomedical applications. Gaining deeper understanding underlying mechanisms emerging research will facilitate development optochemically controlled photoresponsive systems, further enhancing
Язык: Английский
Процитировано
0
APOPTOSIS, Год журнала: 2024, Номер unknown
Опубликована: Июнь 9, 2024
Abstract Ferroptosis is a form of cell death that triggered by the presence ferrous ions and characterized lipid peroxidation induced these ions. The mechanism exhibits distinct morphological characteristics compared to apoptosis, autophagy, necrosis. A notable aspect ferroptosis its ability inhibit uncontrolled tumor replication immortalization, especially in malignant, drug-resistant, metastatic tumors. Additionally, immunotherapy, novel therapeutic approach for tumors, has been found have reciprocal regulatory relationship with context anti-tumor therapy. comprehensive analysis immunotherapy therapy presented this paper, highlighting potential mutual adjuvant effects. Specifically, we discuss mechanisms underlying emphasizing their improve immune microenvironment enhance immunotherapeutic Furthermore, investigate how factors may increase sensitivity cells ferroptosis. We aim provide prospective view promising value combined anticancer elucidating network between each. Graphical involves intricate crosstalk cells. Through MHC recognition, CD8 + T activate JAK1/STAT1 pathway cells, impairing function System Xc reducing GSH GPX4 expression promote activation STAT1-IRF1-ACSL4 could also blockade antioxidant induces ferroptosis, released DAMPs DCs maturation through cGAMP-STING-TBK1 pathway, leading antigen presentation activates release M1-type polarization macrophages, which exerts an effect. effects be enhanced blocking inhibitory checkpoints such as PD-1, PD-L1, CTLA4, LAG3. Abbreviations: ACSL4, acyl-CoA synthetase long-chain family member 4; BH4, tetrahydrobiopterin; cGAMP, cyclic GMP-AMP; cytotoxic lymphocyte-associated antigen-4; DCs, dendritic cells; DHFR, dihydrofolate reductase; DHODH, dihydroorotate dehydrogenase; GPX4, glutathione peroxidase GSH, glutathione; HIF-1α, Hypoxia-Inducible Factor-1α;IFN-γ, interferon-γ; IRF1, interferon factor 1;IRP1, iron protein 1; JAK 1, janus kinase; LAG3, lymphocyte gene 3; MHC, major histocompatibility complex; NRF2, nuclear erythroid-2-related 2; programmed -1; ligand PUFA, polyunsaturated fatty acid; ROS, reative oxygen species; STAT1, signal transducer activator transcription STING, stimulator genes; TBK1, TANK-binding kinase 1 TLR2, toll-like receptor 2. This diagram was drawn Figdraw ( www.figdraw.com ).
Язык: Английский
Процитировано
3
Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(7), С. 7239 - 7257
Опубликована: Июль 8, 2024
Photodynamic therapy (PDT) can not only directly eliminate cancer cells, but also stimulate antitumor immune responses. It affects the expression of checkpoints. The purpose this review is to collect, analyze, and summarize recent news about PDT checkpoints, along with their inhibitors, identify future research directions that may enhance effectiveness approach. A search for articles published between January 2023 March 2024 was conducted in PubMed/MEDLINE. Eligibility criteria were as follows: (1) papers describing (2) original papers, (3) new reports field (4) both vitro vivo papers. Exclusion included written a language other than Polish or English, before 2023. 24 data on checkpoints have been since These information effects attempts associate ICI molecules modulate improve immunosuppressive environment tumor, resolve PDT-related problems. They focused development nanoparticles delivery photosensitizers drugs selectively tumor. effect level associated activity system has fully elucidated further, area are divergent, indicating complexity interaction system. PDT-based strategies shown beneficial utility enhancing induction response by participating triggering immunogenic cell death, exposure tumor antigens, release various alarm signals together promote activation dendritic cells components demonstrated, result induced therapy. enables multifaceted regulation tumor’s environment, which potential achieve better efficacy. current presented evidence PDT’s ability association ICIs inducing an effective against cells. However, these studies at early stage many more observations need be made confirm indicated contribute further strategies.
Язык: Английский
Процитировано
3