Materials Today Physics, Год журнала: 2024, Номер 47, С. 101535 - 101535
Опубликована: Авг. 20, 2024
Язык: Английский
Antibiotics, Год журнала: 2025, Номер 14(2), С. 207 - 207
Опубликована: Фев. 18, 2025
The rapid rise of antibiotic resistance has become a global health crisis, necessitating the development innovative strategies to combat multidrug-resistant (MDR) pathogens. Nanomaterials have emerged as promising tools in this fight, offering unique physicochemical properties that enhance efficacy, overcome mechanisms, and provide alternative therapeutic approaches. This review explores diverse nanomaterial-based used resistance, focusing on their mechanisms action practical applications. such metal nanoparticles, carbon-based nanomaterials, polymeric nanostructures exhibit antibacterial through various pathways, including generation reactive oxygen species (ROS), disruption bacterial membranes, enhancement delivery. Additionally, ability nanomaterials bypass traditional biofilm formation efflux pumps, been demonstrated numerous studies. also discusses synergistic effects observed when are combined with conventional antibiotics, leading increased susceptibility reduced required dosages. By highlighting recent advancements clinical applications nanomaterial-antibiotic combinations, paper provides comprehensive overview how reshaping future therapies. Future research directions challenges, toxicity scalability, addressed guide safer, more effective treatments.
Язык: Английский
Процитировано
2
Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 14
Опубликована: Апрель 7, 2025
Nitric oxide (NO) is essential for wound healing, promoting angiogenesis and collagen deposition. This study investigates a novel dual-matrix nanocomposite hydrogel incorporating S-nitrosoglutathione (GSNO), physiological NO donor, to enhance cutaneous healing. GSNO was encapsulated in ammonio methacrylate copolymer nanoparticles embedded an alginate-based matrix, achieving controlled release. GSNO-loaded were prepared using solvent displacement evaporation methods, resulting spherical, well-distributed positively charged particles. These cross-linked with negatively alginic acid form hydrogel. The hydrophobic protected from degradation, while the hydrophilic alginate matrix sustained release of active up 10 h, haemostasis maintaining moist environment. exhibited good biocompatibility human fibroblasts significantly enhanced repair by fibroblast formation, neovascularisation deposition, as demonstrated haematoxylin eosin staining Masson's trichrome staining. In conclusion, accelerated healing process enhancing offering promising strategy improving
Язык: Английский
Процитировано
0
Biomaterials Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Plant-derived cytoderm ghost (PCG) drug delivery systems leverage bacterial responsiveness to enable controlled release of drugs for treatment related diseases.
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2023, Номер 13(3)
Опубликована: Ноя. 1, 2023
Abstract Antimicrobial‐resistant bacterial infections threaten to become the number one cause of death by year 2050. Since speed at which antimicrobial‐resistance develops is exceeding pace new antimicrobials come market, this threat cannot be countered making more, and stronger antimicrobials. Promising should not only kill antimicrobial‐resistant bacteria, but also prevent development resistance mechanisms in strains still susceptible. Here, PAMAM‐dendrimers are clustered using glutaraldehyde form megamers that core‐loaded with ciprofloxacin functionalized HA‐SNO. Megamers enzymatically disintegrated an acidic pH, as infectious biofilms, yielding release NO‐generation does contribute killing planktonic Gram‐positive Staphylococcus aureus Gram‐negative Pseudomonas aeruginosa , a biofilm‐mode growth short‐lived NO‐assisted both ciprofloxacin‐susceptible ciprofloxacin‐resistant released. Repeated sub‐culturing bacteria presence ciprofloxacin‐loaded HA‐SNO PAMAM‐megamers result variants repeated culturing ciprofloxacin. Healing wounds infected S. variant treated ciprofloxacin‐loaded, proceed faster through infecting stimulation angiogenesis.
Язык: Английский
Процитировано
8
European Journal of Nuclear Medicine and Molecular Imaging, Год журнала: 2024, Номер 51(13), С. 4165 - 4176
Опубликована: Июль 26, 2024
Язык: Английский
Процитировано
2
Nano Today, Год журнала: 2024, Номер 58, С. 102449 - 102449
Опубликована: Авг. 16, 2024
Процитировано
2
ACS Infectious Diseases, Год журнала: 2024, Номер 10(6), С. 2018 - 2031
Опубликована: Май 14, 2024
Antibiotic abuse leads to increased bacterial resistance, and the surviving planktonic bacteria aggregate secrete extracellular polymers form biofilms. Conventional antibacterial agents find it difficult penetrate biofilm, remove wrapped in it, produce an excellent therapeutic effect. In this study, a dual pH- NIR-responsive nanocomposite (A-Ca@PDA) was developed drug-resistant through cascade of catalytic nitric oxide (NO) release photothermal clearance. NO can melt outer package facilitating nanocomposites have better permeability. Thermal therapy further inhibits growth bacteria. The locally generated high temperature burst together aggravate biofilm collapse death after NIR irradiation. achieved remarkable conversion efficiency 47.5%, thereby exhibiting significant advancements energy conversion. exhibited efficacy inhibiting multidrug-resistant (MDR) Escherichia coli MDR Staphylococcus aureus, thus achieving inhibition rate >90%. Moreover, these significantly improved wound-healing process S. aureus-infected mice. Thus, novel offers strategy combat infections.
Язык: Английский
Процитировано
1
Materials Today Physics, Год журнала: 2024, Номер 47, С. 101535 - 101535
Опубликована: Авг. 20, 2024
Язык: Английский
Процитировано
0