Transition-metal-based nanozymes for biosensing and catalytic tumor therapy

Analytical and Bioanalytical Chemistry, Год журнала: 2024, Номер 416(27), С. 5933 - 5948

Опубликована: Май 23, 2024

Язык: Английский

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A Photoactivated Self‐Assembled Nanoreactor for Inducing Cascade‐Amplified Oxidative Stress toward Type I Photodynamic Therapy in Hypoxic Tumors

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Авг. 5, 2024

Abstract Type I photodynamic therapy (PDT) generates reactive oxygen species (ROS) through oxygen‐independent photoreactions, making it a promising method for treating hypoxic tumors. However, the superoxide anion (O 2 ∙ – ) generated usually exhibits low oxidation capacity, restricting antitumor efficacy of PDT in clinical practice. Herein, photoactivated self‐assembled nanoreactor ( 1 ‐NBS@CeO is designed integration type and cerium oxide (CeO nanozymes inducing cascade‐amplified oxidative stress The constructed though co‐assembly an amphiphilic peptide ‐NBS) CeO , giving well‐dispersed spherical nanoparticles with enhanced dismutase (SOD)‐like peroxidase (POD)‐like activities. Following light irradiation, undergoes photoreactions to O which further catalyzed by nanoreactors, ultimately forming hypertoxic hydroxyl radical (∙OH) reactions. treatment using results elevation intracellular ROS depletion GSH content A375 cells, thereby mitochondrial dysfunction triggering apoptosis ferroptosis tumor cells. Importantly, intravenous administration alongside irradiation showcases enhances satisfactory biocompatibility vivo. Together, facilitates achieving efficacious PDT, holds great promise developing therapeutic modules towards

Язык: Английский

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Advances in stimuli-responsive polymeric hydrogels for anticancer drug delivery: A review

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 102, С. 106394 - 106394

Опубликована: Ноя. 8, 2024

Язык: Английский

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Mn-Doped CeO₂ Nanorods for the Colorimetric Sensing of Glutathione

ACS Applied Nano Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

Язык: Английский

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Thienylquinoline-Based Ionic Iridium(III) Complexes as Highly Efficient Sonosensitizers for Sonodynamic Therapy

Journal of Organometallic Chemistry, Год журнала: 2025, Номер unknown, С. 123547 - 123547

Опубликована: Янв. 1, 2025

Язык: Английский

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Visible-light-driven photodegradation of Pt-derivative anticancer drug carboplatin over La-Fe-modified SrTiO3 with simultaneous doping and enhanced Pt-photodeposited catalyst

Journal of Water Process Engineering, Год журнала: 2025, Номер 71, С. 107387 - 107387

Опубликована: Март 1, 2025

Язык: Английский

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Dopant‐Regulated Piezocatalysts Evoke Sonopiezoelectric and Enzymatic PANoptosis for Synergistic Cancer Therapy

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Март 8, 2025

Piezocatalyst-enabled sonopiezoelectric therapy offers noninvasive treatment with high spatiotemporal selectivity, yet existing piezocatalysts are limited by suboptimal efficacy, cancer cell resistance to oxidative stress, and biosafety concerns. Here, hafnia (HfO2), one of the only few FDA-approved inorganic nanomaterials for clinical trials, is identified as a promising piezocatalyst translational potential enzymatic PANoptosis-boosted nanocatalytic therapy. Specifically, engineered transition metal-substituted HfO2 nanocatalysts synthesized optimize piezoelectric enzyme-mimicking activities. Among these, Mn-substituted 20% Mn ratio (HMO) demonstrates superior performance in sono-triggered reactive oxygen species generation, attributed its reduced bandgap increased vacancies. HMO also exhibits multiple activities, including peroxidase (POD), catalase (CAT), glutathione (GPx), amplifying stress through tumor-specific catalytic reactions. These dual effects enable activation PANoptosis elicit robust antitumor immune response. Biological evaluations show significant tumor suppression responses HMO-mediated Unlike utilizing radiosensitization ability clinic, this work unveils distinctive effect multienzymatic activities HfO2-based biomedical applications, holding overcome challenges radiation damage associated radiotherapy.

Язык: Английский

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Dual-upregulation of p53 for self-sensitized cuproptosis via microwave dynamic and NO gas therapy

Journal of Colloid and Interface Science, Год журнала: 2025, Номер unknown, С. 137421 - 137421

Опубликована: Март 1, 2025

Язык: Английский

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Bionic Menisci with Integrated Material–Structure–Functionality for Gouty Arthritis

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер unknown, С. 114672 - 114672

Опубликована: Апрель 1, 2025

Язык: Английский

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Recent advances in polydopamine-coated metal–organic frameworks for cancer therapy

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Апрель 1, 2025

The creation and development of classical multifunctional nanomaterials are crucial for the advancement nanotherapeutic treatments tumors. Currently, metal–organic frameworks (MOFs) modified with polydopamine (PDA) at forefront nanomedicine research, particularly in tumor diagnostics therapy, owing to their exceptional biocompatibility, expansive specific surface area, multifaceted functionalities, superior photothermal properties, which led significant advancements anti-tumor research. Consequently, a range anti-cancer strategies has been devised by leveraging capabilities MOFs, including intelligent drug delivery systems, photodynamic tailored microenvironment. In order gain deeper insight into role MOFs@PDA cancer diagnosis treatment, it is essential conduct comprehensive review existing research outcomes promptly analyze challenges associated biological applications. This will provide valuable perspectives on potential clinical settings.

Язык: Английский

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