Materials Today Bio, Год журнала: 2024, Номер 30, С. 101435 - 101435
Опубликована: Дек. 28, 2024
Язык: Английский
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Апрель 8, 2025
Host immune rejection has long been recognized as a major contributor to the poor survival rates of exogenous stem cells (ESCs). In this study, we present simple and versatile strategy protect ESCs from host system insults by developing protective "armor." This armor was designed using tannic acid (TA), leveraging its strong affinity for biomacromolecules anti-inflammatory properties. Prior implantation, can be readily applied surface individual ESCs, cell aggregates, sheets, or cell-laden hydrogel systems simply immersing them in TA solution several seconds, without additional processing steps. The TA-based effectively modulates acute inflammatory response during initial days postimplantation scavenging reactive oxygen species (ROS), thereby creating an ESCs-friendly microenvironment. evidenced reduction infiltration pro-inflammatory secretion cytokines. Consequently, engrafted significantly enhanced, with preserved stemness immunomodulatory functions. regenerative potential further demonstrated rat periodontal defect model. These findings provide novel approach enhancing performance offer straightforward shield rejection.
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Апрель 24, 2025
Atopic dermatitis (AD) is a chronic inflammatory skin disorder marked by thickening, severe pruritus, lesions, and emotional disturbances, including anxiety depression-like behavior. Current treatments primarily rely on localized therapies, which can lead to adverse effects such as hyperglycemia Cushing's syndrome with repeated use. To address these issues, we developed hyaluronic acid-based separable microneedle patch (Dic@pCu-HA MN), integrating polydopamine-coordinated copper-based metal-organic frameworks (pCu-MOFs) the anti-inflammatory agent dictamnine (Dic), for synergistic management of AD its neuropsychiatric comorbidities. pCu-MOFs exhibited dual functionality nanocargo hydrophobic Dic (encapsulation efficiency: 84.62 ± 2.14%) multienzyme mimics that efficiently scavenge reactive oxygen species (ROS) (superoxide radical scavenging: 63.85 0.34%). In vitro release studies demonstrated ROS-responsive 86.80 4.83% over 48 h under pathology-mimicking conditions. 1-Chloro-2,4-dinitrochlorobenzene (DNCB)-induced mouse model, Dic@pCu-HA MN significantly reduced oxidative stress (8-OHdG: 85.1 7.0% decrease), suppressed pro-inflammatory cytokines (IL-4: 70.0 7.8% decrease vs control), restored barrier integrity. By modulating HPA axis, system attenuated neuroinflammation alleviated itching (scratching frequency: 40.1 41.3% reduction) behavior (time in bright box: 96.6 156.2% increase). This combined therapeutic approach not only offers comprehensive strategy but also provides potential benefits addressing disorders their sequelae.
Язык: Английский
Процитировано
0
Industrial Crops and Products, Год журнала: 2024, Номер 221, С. 119333 - 119333
Опубликована: Июль 30, 2024
Язык: Английский
Процитировано
3
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Дек. 20, 2024
Periodontitis is a chronic inflammatory disease caused by dental plaque, which leads to tooth loosening and shifting or even loss. Current treatments, including mechanical debridement antibiotics, often fail eradicate recalcitrant biofilms mitigate excessive inflammation. Moreover, these interventions can disrupt the oral microbiome, potentially compromising long-term treatment outcomes. To address limitations, an injectable nanoenzyme hydrogel composed of dopamine (DA)-modified hyaluronic acid (HA) scaffold graphdiyne-iron (GDY-Fe) complex, named GDY-Fe@HA-DA, exhibits excellent tissue adhesion, self-healing, antibacterial properties, biocompatibility. Under near-infrared laser irradiation, GDY-Fe@HA-DA effectively eradicates variety pathogens, Escherichia coli, Staphylococcus aureus, Porphyromonas gingivalis, through synergistic combination chemodynamical photothermal therapies. The hydrogel's efficacy further validated in both bacterial-infected skin wounds rat periodontitis models. It alleviates environment promotes wound healing periodontal recovery. This findings highlight potential as promising therapeutic material for other injuries.
Язык: Английский
Процитировано
3
ACS Applied Polymer Materials, Год журнала: 2024, Номер 6(14), С. 8548 - 8559
Опубликована: Июль 16, 2024
The use of hydrogel strain sensors in flexible electronic wearable devices has garnered significant attention. However, achieving hydrogels with comprehensive properties such as excellent tensile strength, strong adhesion, rapid self-healing, and high sensitivity simultaneously remains challenging. Herein, inspired by mussels, we developed a straightforward polymerization process an aqueous solution using the polymerizable monomer 3-methylacryloyldopamine, containing catechol structural unit, along acrylic acid, sodium acrylate, ethylene imine polymer, zwitterionic [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl). This resulted double-network structure featuring multiple dynamic interactions. sensor exhibited remarkable (up to 4200%), adhesion (adhesion for wood: 3370 kPa), self-healing ability (3 s), (GF = 13.75), allowing accurate repeatable detection both large-scale subtle human movements. Furthermore, addition glycerol endowed capability functioning at low temperatures (−40 °C). Such adhesive dopamine-based also potential skins, dressing, human–machine interface.
Язык: Английский
Процитировано
2
Small Science, Год журнала: 2024, Номер 5(1)
Опубликована: Ноя. 21, 2024
Human-machine interface (HMI) electrodes enable interactions between humans and bioelectronic devices by facilitating electrical stimulation recording neural activity. However, reconciling the soft, hydrated nature of living human tissues with rigid, dry properties synthetic electronic systems is inherently challenging. Overcoming these significant differences, which critical for developing compatible, effective, stable interfaces, has become a key research area in materials science technology. Recently, hydrogels have gained prominence use HMI because are similar to can be tuned through incorporation nanofillers. This review examines functional requirements highlights recent progress development polyphenol-mediated multifunctional hydrogel-based bioelectronics. Furthermore, aspects such as mussel-inspired adhesion, underlying mechanisms, tissue-matching mechanical properties, electrochemical performance, biocompatibility, biofouling resistance, stability under physiological conditions, anti-inflammatory, antioxidant discussed. Finally, applications bioelectronics further perspectives outlined. Advances hydrogel expected facilitate unprecedented integration biological devices, potentially revolutionizing various biomedical fields enhancing capabilities performance devices.
Язык: Английский
Процитировано
2
Polymer science & technology., Год журнала: 2024, Номер unknown
Опубликована: Дек. 12, 2024
Conductive hydrogels have garnered significant attention in the realm of future flexible electronic devices due to their properties such as flexibility, electrical conductivity, frost resistance, and biocompatibility. However, integration numerous functional applications biomedical field still presents notable challenges. In this research, a rigid hard-structured network was formed by cross-linking gallic acid grafted chitosan (CS–GA) tannic (TA) with poly(vinyl alcohol) (PVA) through physical freezing. The noncovalent hydrogen bonding during freezing thawing process facilitated formation microcrystalline domains amorphous hydrogel system. Functional proteins from eggshell membrane were cross-linked tetra-armed poly(ethylene glycol) maleimide (4am-PEG-MAL) via thiol-olefin click chemistry, lysozyme incorporated into an antibacterial component nucleophilic substitution reaction. These chemical methods resulted soft-structured that enhanced mechanical (maximum stress 2.15 MPa elongation 605%). use ionic liquids/ethylene glycol/water (ILs/EG/H2O) ternary solvents instead single solvent not only provided resistance but also imparted excellent conductivity (0.37 ± 0.04 S/m). Notably, organohydrogel showed good antimicrobial biocompatibility effective providing emergency cooling after fireworks burns promoting wet healing broken skin minimize scarring. field, multifunctional can serve wearable device monitor movement amplitude wounds real-time, offering novel approach deep learning-assisted wound healing. nature biological promising applications.
Язык: Английский
Процитировано
2
Biomaterials Research, Год журнала: 2024, Номер 28
Опубликована: Янв. 1, 2024
Epigallocatechin gallate (EGCG), a naturally occurring compound known for its multiple health benefits including antioxidant, anti-inflammatory, cancer preventive, and weight management effects, faces challenges due to inherent instability limited bioavailability. To address these limitations, our study pioneers an investigation into the unique behavior of EGCG, revealing degradation epicatechin (EGC) gallic acid (GA) during drug delivery process. In this research, we use fluorescent mesoporous silica nanoparticles (FMSNs) as sophisticated system EGCG. This innovative approach aims not only enhance stability EGCG but also regulate sustained release dynamics enable prolonged cellular activity. comprehensively evaluate novel strategy, performed assays assess both antioxidant potential impact on lipid inhibition using Oil Red O. The results underscore FMSN-based nanocarriers efficient reveal groundbreaking insights enzymatic degradation, previously unexplored facet. research substantially advances understanding EGCG's offers promising avenue improving therapeutic efficacy expanding applications in management.
Язык: Английский
Процитировано
0
Current Organic Chemistry, Год журнала: 2024, Номер 29(3), С. 165 - 180
Опубликована: Июль 23, 2024
: Chitosan (CS) is a natural polymer obtained by removing acetyl groups from chitin through alkaline hydrolysis. It possesses biodegradable properties and exhibits immunological, antibacterial, wound-healing activities. This polysaccharide has undergone modification radiation-induced graft copolymerization to broaden its application scope. The potential applications of CS can be expanded introducing side chains grafting. article aims review the innovative alternatives gamma-graftcopolymerized and, for first time, comprehensively examines current derivatives in dye removal, metal adsorption, antibacterial interventions, biomedical practices, drug delivery systems, tissue engineering.
Язык: Английский
Процитировано
0
Journal of Materials Chemistry B, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Photocrosslinkable hydrogel of chitosan–drug conjugate with great anti-inflammatory activity used for biomedical applications.
Язык: Английский
Процитировано
0