Alisol A 24-Acetate combats Methicillin-Resistant Staphylococcus aureus infection by targeting the mevalonate biosynthesis

Biochemical Pharmacology, Год журнала: 2025, Номер 233, С. 116766 - 116766

Опубликована: Янв. 31, 2025

Язык: Английский

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Tofacitinib Citrate Coordination‐Based Dual‐Responsive/Scavenge Nanoplatform Toward Regulate Colonic Inflammatory Microenvironment for Relieving Colitis

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(30)

Опубликована: Авг. 23, 2024

Abstract Ulcerative colitis is an inflammation of the colon characterized by immune dysregulation and intestinal inflammation. Developing safe oral nanomedicines that suppress inflammation, while modulating colonic inflammatory microenvironment scavenging reactive oxygen species (ROS) hydrogen sulfide (H 2 S) crucial for effective treatment colitis. Here, tofacitinib citrate copper coordination‐based nanoparticle (TF‐Cu nanoparticle, T‐C) to dual‐scavenge ROS H S coordination competition synthesized. Moreover, T‐C using computer simulation explored. To enhance acid stability targeting T‐C, it encapsulated with hyaluronic acid‐modified chitosan, along a calcium pectinate coating (T‐C@HP). Owing dual pH/pectinase‐responsive characteristics T‐C@HP, nanoplatform can target inflamed lesions, inhibiting phosphorylated Janus kinase 1. Furthermore, T‐C@HP scavenges S, as well increases NADPH levels, which investigated combining biosensor (HyPer7 iNap1/c) chemical probes. also alleviates regulating through multiple processes, including modulation apoptosis, macrophage polarization, tight junction, mucus layer, flora. Complemented satisfactory anti‐inflammatory biosafety results, this represents promising, effective, option patients.

Язык: Английский

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The curcumin-loaded zein-shellac nanoparticles using pH-driven method: Fabrication, characterization, and anti-inflammatory effect

Journal of Functional Foods, Год журнала: 2025, Номер 125, С. 106692 - 106692

Опубликована: Янв. 27, 2025

Язык: Английский

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pH-responsive and self-adaptive injectable sodium alginate/carboxymethyl chitosan hydrogel accelerates infected wound healing by bacteriostasis and immunomodulation

Carbohydrate Polymers, Год журнала: 2025, Номер unknown, С. 123322 - 123322

Опубликована: Янв. 1, 2025

Язык: Английский

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Inulin Hydrogel Loaded with Self-Assembled Nanoparticles of Curcumin and Glycyrrhizic Acid for Inflammatory Bowel Disease Treatment Via Anti-Inflammation, Antioxidation, and Microbiota Modulation

Опубликована: Янв. 1, 2025

Язык: Английский

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Orally Administrated Precision Nanomedicine for Restoring the Intestinal Barrier and Alleviating Inflammation in Treatment of Inflammatory Bowel Disease

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

Inflammatory bowel disease (IBD) presents a significant challenge in healthcare, characterized by its chronicity and complex pathogenesis involving genetic, immune, environmental factors. Current treatment modalities, including anti-inflammatory drugs, immunomodulators, biologics, often lack sufficient efficacy are accompanied adverse effects, necessitating the urgent search for therapeutic approaches targeting mucosal barrier restoration inflammation modulation. Precision nanomedicine emerges as promising solution to directly address these challenges. This study introduces development of targeted sequential precise IBD treatment. innovative formulation combines prodrug carrier containing quercetin restore intestinal integrity through regulation tight junctions an agent dexamethasone acetate alleviate inflammation. Surface modification with pectin enables colon-specific drug delivery, facilitated degradation microbiota. Responsive release, controlled reactive oxygen species-sensitive chemical bonds within carrier, ensures both spatial temporal accuracy. In vitro vivo investigations confirm nanomedicine's favorable physicochemical properties, release kinetics, efficacy, elucidating potential underlying mechanisms. Oral administration shows results restoring function, reducing inflammation, modulating gut Consequently, this candidate advancing paradigms.

Язык: Английский

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Curcumin targets YAP1 to enhance mitochondrial function and autophagy, protecting against UVB-induced photodamage

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 25, 2025

Background Ultraviolet B (UVB) radiation is a major environmental factor contributing to skin damage via DNA damage, oxidative stress, inflammation, and collagen degradation. It penetrates the epidermis, disrupts integrity, generates reactive oxygen species (ROS), activating pro-inflammatory pathways such as NF-κB AP-1, inducing matrix metalloproteinases (MMPs). These processes lead structural changes, pigmentation disorders like melasma. Cumulative from UVB also drives photocarcinogenesis, with nearly 90% of melanomas associated UV (UVR). Despite clinical interventions phototherapy antioxidants, effective treatments for UVB-induced remain limited due side effects efficacy issues. Methods This study investigates protective curcumin on using mouse irradiation model HaCaT cells exposed in vitro . Skin was assessed through histopathological immunohistochemical analyses. Cellular functional changes were evaluated assays cell viability, mitochondrial function, ROS levels, apoptosis. Transcriptomic analysis employed elucidate molecular mechanisms underlying curcumin’s post-UVB exposure. integrated approach provides comprehensive understanding molecular-level protection against damage. Results Curcumin significantly alleviated lesions inflammation vivo In , it mitigated enhancing viability while reducing apoptosis levels. revealed that upregulated YAP signaling autophagy suppressing IL-18 expression. Conclusion treatment markedly improved reduced epidermal thickness intervention including increased apoptosis, elevated enhanced inflammatory responses. demonstrated pathway inhibiting pathway. Further studies directly interacts YAP1, promoting autophagy, an effect blocked by YAP1 inhibitor Verteporfin. Additionally, enhances function maintaining integrity preventing release (mtDNA) (mtROS), thereby NLRP3/IL-18 activation.

Язык: Английский

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A hydrogel-based composite facilitates efficient and recyclable tetracycline biodegradation in aquatic environments

Environmental Research, Год журнала: 2025, Номер unknown, С. 121524 - 121524

Опубликована: Апрель 1, 2025

Язык: Английский

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Oral enzyme-responsive nanoprobes for targeted theranostics of inflammatory bowel disease

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Авг. 13, 2024

Inflammatory bowel disease (IBD) is a progressive and debilitating inflammatory of the gastrointestinal tract (GIT). Despite recent advances, precise treatment noninvasive monitoring remain challenging.

Язык: Английский

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Natural medicines-derived carbon dots as novel oral antioxidant administration strategy for ulcerative colitis therapy

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Авг. 27, 2024

Abstract Background Ulcerative colitis (UC) is a chronic intestinal inflammation, resulting in global healthcare challenge with no real specific medicine. Natural medicines are recognized as potential clinical alternative therapy, but their applications limited by poor solubility and low bioavailability. Results In this work, inspired the natural of ancient China, novel functional carbon dots derived from Magnetite Medicated Leaven (MML-CDs) were synthesized hydrothermal method, confirmed ultrasmall nano-size (3.2 ± 0.6 nm) Fe doped surface structure, thereby excellent gastrointestinal stability, remarkable capabilities eliminating ROS, highly biocompatibility. With external stimuli, oral administration MML-CDs demonstrated obvious alleviation to UC. Further experiments pointed that could improve hemostasis capability, suppress inflammation reactions oxidative stress, up-regulate expression tight junction proteins. Furthermore, also showed well regulation dysbiosis flora. Conclusion Overall, above evidence reveals green-synthesized can significantly alleviate bleeding, inhibit colon repair colonic barrier damage, further regulating flora microenvironment. Our findings provide an efficient therapy strategy for ulcerative colitis. Graphical

Язык: Английский

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