Engineered hydrogel platform for diabetic wound healing
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 160379 - 160379
Опубликована: Фев. 1, 2025
Язык: Английский
The preparation of methacrylated oxidized konjac glucomannan hydrogel system and its treatment for diabetic wounds
Xi Pan,
Qida Zong,
Bo Fu
и другие.
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 140005 - 140005
Опубликована: Янв. 1, 2025
Язык: Английский
Asiaticoside-Loaded Multifunctional Bioscaffolds for Enhanced Hyperglycemic Wound Healing
Biomedicines,
Год журнала:
2025,
Номер
13(2), С. 277 - 277
Опубликована: Янв. 23, 2025
The
review
explores
the
potential
of
asiaticoside-loaded
bioscaffolds
to
improve
management
hyperglycemic
wounds,
particularly
diabetic
foot
ulcers
(DFUs).
Asiaticoside,
sourced
from
Centella
asiatica,
possesses
properties
that
address
DFUs’
healing
challenges:
insufficient
angiogenesis,
persistent
inflammation,
and
delayed
tissue
regeneration.
By
incorporating
asiaticoside
into
bioscaffold
3D
designs
including
hydrogels,
microneedle
arrays,
nanofibrous
meshes,
therapeutic
efficacy
is
optimized.
This
examines
mechanisms
in
wound
(collagen
production,
angiogenesis
modulation,
inflammation
reduction,
cell
migration
proliferation)
based
on
vitro
vivo
studies.
Asiaticoside
also
demonstrates
synergistic
abilities
with
other
biomaterials,
creating
possibility
more
effective
therapies.
While
preclinical
research
promising,
clinical
trials
are
crucial
evaluate
safety
patients
DFUs.
Asiaticoside-loaded
a
significant
development
may
aid
treating
complications.
Their
ability
offer
individualized
treatment
plans
has
enhance
quality
life
those
who
suffer
diabetes.
thorough
literature
search
(2019–2024)
across
multiple
databases,
excluding
secondary
non-English
articles.
Язык: Английский
Origanum vulgare ssp. hirtum: From Plant to 3D-Printed Gummies with Antioxidant and Anti-Inflammatory Properties
Gels,
Год журнала:
2025,
Номер
11(4), С. 246 - 246
Опубликована: Март 26, 2025
This
study
investigates
the
phytochemical
profile,
antioxidant
and
anti-inflammatory
properties,
3D-printing
application
of
Origanum
vulgare
L.
ssp.
hirtum
extract.
The
extract
revealed
a
diverse
range
phenolic
compounds,
with
rosmarinic
acid
as
predominant
compound
(47.76%).
showed
moderate
to
high
lipoxygenase
inhibition
(IC50
=
32.0
µg/mL),
suggesting
its
potential
an
agent.
It
also
exhibited
strong
activity,
hydrogen
peroxide
scavenging
(SC50
99.2
µg/mL)
hydroxyl
radical
64.12
capabilities.
In
cellular
studies,
concentrations
(50
µg/mL
100
significantly
decreased
intracellular
ROS
production
in
Caco-2
cells
(reductions
exceeding
53%
64%,
respectively).
Moreover,
suppressed
NO
LPS-stimulated
J774A.1
macrophages
concentration-dependent
manner.
explores
incorporation
into
3D-printed
gummies.
gels
shear-thinning
behavior,
which
was
essential
for
successful
extrusion-based
3D
printing.
influenced
mechanical
strength
compaction
properties
gummies
before
breaking
(1.6-fold
increase)
allowing
better
mouth
feeling.
PXRD
FTIR
analyses
confirmed
amorphous
nature
interaction
between
active
ingredients
excipients
utilized
These
findings
demonstrated
semisolid
extrusion
printing
at
room
temperature
transform
culinary
herb
(Origanum
spp.
hirtum)
healthcare
product
properties.
Язык: Английский
High Self‐Supporting Chitosan‐Based Hydrogel Ink for In Situ 3D Printed Diabetic Wound Dressing
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 13, 2024
Abstract
Customizable
3D‐printed
biopolymer
hydrogels,
highly
sought
after
for
diabetic
wound
management,
face
challenges
in
clinical
application
due
to
weak
physical
crosslinking
within
their
constituent
inks.
In
this
study,
a
novel
chitosan‐based
hydrogel
ink
with
dense
yet
reversible
network
is
subtly
designed
the
rapid
situ
fabrication
of
personalized
dressing.
This
robust
established
through
multiple
electrostatic
and
hydrogen
bonding
interactions
between
unique
carboxymethyl
chitosan
nanoclay,
further
reinforced
by
introduction
amide
bonds,
which
act
as
double
bond
donors/acceptors.
Benefiting
from
network,
low
nanoclay
content
exhibits
remarkable
self‐supporting
properties,
enabling
high‐fidelity,
large‐scale,
complex
3D
printability
without
additional
processing,
while
substantially
retaining
its
inherent
rheological
properties
autoclave
sterilization
incorporation
active
components.
Given
these
advantages,
multifunctional
printable
can
be
rapidly
constructed
on
wounds.
Simultaneously,
demonstrates
biodegradability,
anti‐swelling,
appropriate
mechanical
along
vitro
antibacterial
pro‐angiogenic
capabilities,
leading
effective
healing
vivo.
work
offers
new
strategy
creating
inks
paves
way
developing
advanced
dressings.
Язык: Английский
Emerging Technological Advancement for Chronic Wound Treatment and Their Role in Accelerating Wound Healing
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(11), С. 7101 - 7132
Опубликована: Окт. 28, 2024
Chronic
wounds
are
a
major
healthcare
burden
and
may
severely
affect
the
social,
mental,
economic
status
of
patients.
Any
impairment
in
wound
healing
stages
due
to
underlying
factors
leads
prolonged
time
subsequently
chronic
wounds.
Traditional
approaches
for
treatment
include
dressing
free
local
therapy,
tissue
engineering
based
scaffold
therapies.
However,
traditional
therapies
need
improvisation
have
been
advanced
through
breakthrough
technologies.
The
present
review
spans
further
gives
an
extensive
account
advancements
Cutting
edge
technologies,
such
as
3D
printing,
which
includes
inkjet
fused
deposition
modeling,
digital
light
processing,
extrusion-based
microneedle
array-based
therapies,
gene
microRNAs
(miRNAs)
smart
dressings
real
monitoring
conditions
assessment
pH,
temperature,
oxygen,
moisture,
metabolites,
their
use
planning
better
strategies
discussed
detail.
future
direction
treatments
that
will
aid
lowering
caused
Язык: Английский
Dual‐Crosslinked Antibacterial Hydrogel for Treatment of Diabetic Foot Ulcers
Macromolecular Chemistry and Physics,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 30, 2024
Abstract
Diabetic
foot
ulcer
has
become
a
heavy
burden
to
the
healthcare
system
with
high
and
growing
incidence
of
diabetes.
Persistent
bacterial
infections
in
diabetic
wounds
can
lead
chronic
inflammation
delayed
wound
healing.
To
address
these
challenges,
dual‐crosslinked
antibacterial
hydrogel
loaded
anti‐inflammatory
compound
asiaticoside
is
developed
this
study.
The
demonstrated
suitable
gelation
properties,
good
biocompatibility,
exceptional
activity.
In
model
on
rats,
asiaticoside‐loaded
alleviate
inflammation,
promote
angiogenesis,
accelerate
Therefore,
shows
considerable
potential
for
Язык: Английский
A review on multifunctional calcium alginate fibers for full-time and multipurposed wound treatment: From fundamentals to advanced applications
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
unknown, С. 139133 - 139133
Опубликована: Дек. 1, 2024
Язык: Английский
Antimicrobial and Antioxidant Hydrogels Based on the Water‐Insoluble β‐Glucan From Poria cocos Loaded With Total Flavonoids of Ampelopsis grossedentata
ChemistrySelect,
Год журнала:
2024,
Номер
9(44)
Опубликована: Ноя. 1, 2024
Abstract
This
study
aims
to
develop
and
assess
an
antimicrobial
hydrogel
that
provides
a
sanitizer
effect
while
avoiding
skin
oxidative
damage.
The
is
composed
of
Poria
cocos
polysaccharide
loaded
with
total
flavonoids
extracted
from
Ampelopsis
grossedentata
(TF@PCPA‐G).
antibacterial
activity
TF@PCPA‐G
was
assessed
through
minimum
inhibitory
concentration
(MIC),
zone
inhibition,
SYTOX
green
staining
measurements.
findings
indicate
exhibited
remarkable
potency.
Additionally,
the
antioxidant
properties
were
examined
using
DPPH,
ABTS,
hydroxyl
radical
scavenging
assay
models,
revealing
possessed
persistent
ability
neutralize
free
radicals.
Subsequently,
further
investigated
cellular
animal
models
As
anticipated,
effectively
alleviated
stress
in
cells
skin.
In
conclusion,
has
been
demonstrated
eliminate
bacteria
prevent
Язык: Английский
On‐Demand 3D Print Mechanically Adaptive Lacrimal Bypass Tube Implants
Advanced Materials Technologies,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 3, 2024
Abstract
Artificial
lacrimal
bypass
tube
(LBT)
implantation
has
been
widely
used
for
treating
proximal
drainage
obstruction.
However,
its
long‐term
clinical
success
is
still
constrained
by
the
frequent
dislodgement
due
to
mismatch
mechanical
properties
surrounding
soft
tissue
and
poor
fusion
along
smooth
surface.
Aiming
tackle
this
challenge,
here
a
method
of
3D
printing
LBT
reported
that
comprises
three
key
features:
1)
adaptability
match
with
characteristics
tissue,
2)
tailorable
surface
porosity
promote
binding,
3)
customization
accommodate
individual
patient's
anatomies.
Using
hydrogel‐based
biocompatible
ink,
LBTs
are
printed
initially
rigid
(compressive
Young's
moduli
E
:
≈1.6
GPa)
ease
surgical
insertion
but
become
compliant
(
0.16–3.36
MPa)
after
better
tissue.
The
inherent
manufacturing
flexibility
enables
integration
porous
shell
prompt
infusion
ensure
integrity.
Ultimately,
in
vivo
intramuscular
orthotopic
studies
demonstrate
exhibit
excellent
tolerance
rabbits
minimal
inflammation
observed,
shells
help
significantly
reduce
dislocation
rate
from
80%
13.3%.
Язык: Английский