Mitochondria-targeting BODIPY nanoprobes for wash-free fluorescence imaging with a high signal-to-noise ratio

Dyes and Pigments, Год журнала: 2025, Номер unknown, С. 112718 - 112718

Опубликована: Фев. 1, 2025

Язык: Английский

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Polyethylene microplastics promote nucleus pulposus cell senescence by inducing oxidative stress via TLR4/NOX2 axis

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 292, С. 117950 - 117950

Опубликована: Фев. 27, 2025

This study aimed to detect and characterize microplastics in intervertebral disc investigate their effects molecular mechanism on degeneration. We collected tissues from cervical, lumbar, thoracolumbar segments used Raman spectroscopy identify microplastics. Among 80 samples, 47 contained microplastics, with polyethylene being the most prevalent type. To explore of (PE-MPs), we established a mouse model nucleus pulposus cell model. Reactive oxygen species (ROS) levels were assessed via immunofluorescence staining, viability was measured using CCK-8 assay, protein expression related Toll-like receptor 4 (TLR4)/NADPH oxidase 2 (NOX2) axis, oxidative stress, degeneration evaluated through western blotting staining. Results showed that PE-MPs exposure led by inducing stress activating TLR4 / NOX2 which increased senescence cells. These mitigated inhibitors. research highlights existence human tissue unveils novel induced PE-MPs, offering new avenues for clinical treatment microplastic-related

Язык: Английский

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Novel pH-responsive Lipid Nanoparticles Deliver UA-Mediated Mitophagy and Ferroptosis for Osteoarthritis Treatment

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101697 - 101697

Опубликована: Март 1, 2025

Язык: Английский

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Engineering the Micro‐Nano Hierarchical Spray Hydrogel for Acute Lung Injury Therapy

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 19, 2025

Abstract Acute lung injury (ALI) poses a significant threat to human health, yet specific treatments remain elusive. Despite extensive research efforts, drug delivery the lungs and reliable preclinical models are major challenges. To address these issues, novel micro‐nano hierarchical spray hydrogel is developed with enhanced targeting ability for treating ALI. The nanocomposite characterized ordered micro‐nanostructure, composing of astaxanthin nanoparticles (ASX‐NPs). Astaxanthin, natural active ingredient derived from algae, nano‐encapsulated produce ASX‐NPs, which significantly improves bioavailability. ASX‐NPs found efficiently target mitochondria relieve inflammatory responses in organoid‐based by downregulating inflammation‐ oxidative stress‐related pathways upregulating mitochondrial energy metabolism. In ALI mice, adheres tracheal mucosa rapidly releases upon inhalation. Released endocytosed alleviate inflammation promote recovery. findings suggest that this system offer promising alternative treatment, can expand applications organoids disease modeling discovery.

Язык: Английский

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Surface Functionalization Strategies of ROS-Scavenging Nanozymes for Synergistic Therapy and Efficient Delivery

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Nanozymes combat oxidative stress-related diseases via surface functionalization strategies (chemical conjugation, physical encapsulation, and drug loading) to enable ROS scavenging, efficient delivery, synergistic therapy.

Язык: Английский

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GM@mTG-V microspheres promote NP regeneration by reconstructing IVD biomechanics and inflammatory microenvironment

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101897 - 101897

Опубликована: Май 1, 2025

Язык: Английский

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Nanozymes targeting mitochondrial repair in disease treatment

Journal of Biotechnology, Год журнала: 2024, Номер 394, С. 57 - 72

Опубликована: Авг. 17, 2024

Язык: Английский

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Nanotechnology-Enhanced Pharmacotherapy for Intervertebral Disc Degeneration Treatment

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 14043 - 14058

Опубликована: Дек. 1, 2024

Intervertebral disc degeneration (IDD) is a primary contributor to chronic back pain and disability globally, with current therapeutic approaches often proving inadequate due the complex nature of its pathophysiology. This review assesses potential nanoparticle-driven pharmacotherapies address intricate challenges presented by IDD. We initially analyze mechanisms driving IDD, particular emphasis on mitochondrial dysfunction, oxidative stress, inflammatory microenvironment, all which play pivotal roles in degeneration. Then, we evaluate application metal-phenolic catalytic nanodots targeting defects alleviating stress within degenerative environment. Additionally, multifunctional stimuli-responsive nanoparticles are explored for their capacity provide precise controlled release, offering improved localization sustained delivery. Finally, outline future research directions identify emerging trends nanoparticle-based therapies, highlighting significantly advance IDD treatment overcoming limitations conventional modalities enabling more effective, targeted management strategies.

Язык: Английский

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The anti-oxidation related bioactive materials for intervertebral disc degeneration regeneration and repair

Bioactive Materials, Год журнала: 2024, Номер 45, С. 19 - 40

Опубликована: Ноя. 9, 2024

Язык: Английский

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TME-responsive nanoplatform for multimodal imaging-guided synergistic precision therapy of esophageal cancer via inhibiting HIF-1α signal pathway

Journal of Controlled Release, Год журнала: 2024, Номер 376, С. 518 - 529

Опубликована: Окт. 23, 2024

Язык: Английский

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