Chemical Communications, Год журнала: 2024, Номер unknown
Опубликована: Дек. 27, 2024
A covalent organic framework-based multifunctional nanomedicine, CuO2@COF-SNO, which can produce reactive oxygen and nitrogen species (ROS/RNS) to enhance chemodynamic therapy of tumors.
Язык: Английский
Materials Chemistry and Physics, Год журнала: 2025, Номер unknown, С. 130888 - 130888
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Май 30, 2024
Photothermal therapy (PTT) is a promising approach for treating tumors that offers multiple advantages. Nevertheless, its practical use in clinical settings faces several limitations, such as suboptimal delivery efficiency, uneven heat distribution, and challenges predicting optimal treatment duration. In addition, the localized hyperthermia generated by PTT method to induce cell apoptosis can result production of excessive reactive oxygen species (ROS) release inflammatory cytokines, which pose threat healthy tissues surrounding tumor. To address above challenges, this work designs an integrated H
Язык: Английский
Процитировано
3
ChemPhysChem, Год журнала: 2024, Номер unknown
Опубликована: Авг. 23, 2024
Abstract The methodology of nanoarchitectonics is to construct functional materials using nanounits such as atoms, molecules, and nanoobjects, just like architecting buildings. Nanoarchitectonics pursues the ultimate concept science through integration related fields. In this review paper, under title interface‐interactive nanoarchitectonics, several examples structure fabrication function development at interfaces will be discussed, highlighting importance with nanoscale considerations. Two sections provide some solid liquid surfaces. interfacial environments, molecular structures can precisely observed analyzed theoretical calculations. Solid surfaces are a prime site for level. has potential pave way cutting‐edge functionality based on advanced observation analysis. Liquid more kinetic dynamic than interfaces, their high fluidity offers many possibilities fabrications by nanoarchitectonics. latter feature advantages in terms freedom interaction diversity components, therefore, may suitable environments functionalities. final section then discusses what needed future material creation
Язык: Английский
Процитировано
3
Nanomaterials, Год журнала: 2024, Номер 14(5), С. 452 - 452
Опубликована: Фев. 29, 2024
Cuprous oxide (Cu2O) has great potential in photodynamic therapy for implant-associated infections due to its good biocompatibility and photoelectric properties. Nevertheless, the rapid recombination of electrons holes weakens antibacterial effect. In this work, a new nanosystem (Cu2O@rGO) with excellent performance was designed via situ growth Cu2O on reduced graphene (rGO). Specifically, rGO lower Fermi levels served as an electron trap capture photoexcited from Cu2O, thereby promoting electron-hole separation. More importantly, surface could quickly transfer owing conductivity, thus efficiently suppressing pairs. Subsequently, Cu2O@rGO nanoparticle introduced into poly-L-lactic acid (PLLA) powder prepare PLLA/Cu2O@rGO porous scaffolds through selective laser sintering. Photochemical analysis showed that photocurrent increased by about two times after incorporation GO nanosheets, enhancing efficiency photogenerated charge carriers Moreover, ROS production scaffold significantly compared PLLA/Cu2O scaffold. The results possessed rates 83.7% 81.3% against Escherichia coli Staphylococcus aureus, respectively. summary, work provides effective strategy combating implant-related infections.
Язык: Английский
Процитировано
2
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 6145 - 6160
Опубликована: Июнь 1, 2024
Background: Combination therapy offers superior therapeutic results compared to monotherapy. However, the outcomes of combination often fall short expectations, mainly because increased toxicity from drug interactions and challenges in achieving desired spatial temporal distribution delivery. Optimizing synergistic ratios ensure uniform targeting across space time, particularly vivo, is a significant challenge. In this study, cRGD-coated liposomes encapsulating optimized cepharanthine (CEP; chemotherapy drug) IR783 (a phototherapy agent) were developed for combined photothermal vitro vivo. Methods: An MTT assay was used evaluate index CEP five cell lines. The cRGD-encapsulated prepared via thin-film hydration, unencapsulated served as controls loading IR783. Fluorescence imaging assess efficacy encapsulated at an optimal ratio, both Results: indices determined As proof-of-concept, ratio (1:2) 4T1 cells evaluated average diameter approximately 100 nm. effectively retained molar over 7 d. vivo fluorescence revealed that signal cRGD-CEP-IR783-Lip detectable tumor site 4 h post-injection peaked 8 h. tumor-bearing mice indicated increase temperature by 32°C within 200 s. Concurrently, demonstrated effect robust biosafety antitumor experiments. Conclusion: successfully exhibiting enhanced effects upon application This study presents novel concept establishes research framework treatment. Keywords: delivery, liposomes, effects,
Язык: Английский
Процитировано
2
Advanced NanoBiomed Research, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Nanoarchitectonics, as a post‐nanotechnology concept, represents methodology for the construction of functional materials employing atoms, molecules, and nanomaterials essential components. The overarching objective nanoarchitectonics is to develop systems comprising multiple units assembled in hierarchical manner, observed biological systems. Nevertheless, such challenging endeavor. It would be prudent, therefore, initially focus on development that interact with complex structures living organisms. Accordingly, this review article addresses topic nanoarchitecture it pertains biomedical applications. This examines current trends research presents examples studies support concept its applications fields. presented are follows: i) molecular developments, which mainly based design assembly; ii) material examples, using components; iii) porous materials, will summarized under heading pore‐engineered due their special structure. Finally, provides an overview these discusses future prospects.
Язык: Английский
Процитировано
2
Theranostics, Год журнала: 2024, Номер 14(10), С. 3997 - 4013
Опубликована: Янв. 1, 2024
Background: Innovative treatment strategies for early-stage breast cancer (BC) are urgently needed.Tumors originating from mammary ductal cells present an opportunity targeted intervention.Methods: We explored intraductal therapy via natural nipple openings as a promising non-invasive approach early BC.Using functional Near-infrared II (NIR-II) nanomaterials, specifically NIR-IIb quantum dots conjugated with Epep polypeptide cell targeting, we conducted in situ imaging and photothermal ablation of ducts.Intraductal administration was followed by stimulation 808 nm laser.Results: This method achieved precise destruction heightened immunological responses the microenvironment.The technique validated mouse models triple-negative BC rat model carcinoma situ, demonstrating therapeutic potential localized prevention.Conclusion: Our study demonstrated effectiveness NIR-II nanoprobes guiding ducts, offering compelling avenue therapy.
Язык: Английский
Процитировано
1
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Авг. 7, 2024
On a global note, oral health plays critical role in improving the overall human health. In this vein, dental-related issues with dentin exposure often facilitate risk of developing various oral-related diseases gums and teeth. Several oral-based ailments include gums-associated (gingivitis or periodontitis), tooth-based (dental caries, root infection, enamel erosion, edentulous total tooth loss), as well miscellaneous buccal cavity (bad breath, mouth sores, cancer). Although established conventional treatment modalities have been available to improve health, these therapeutic options suffer from several limitations, such fail eradicate bacterial biofilms, deprived regeneration dental pulp cells, poor remineralization teeth, resulting emergencies. To end, advent nanotechnology has resulted development innovative nanoarchitectured composites diverse sources. This review presents comprehensive overview different for Initially, we emphasize diseases, providing detailed pathological circumstances their effects on along deficiencies modalities. Further, importance nanostructured components is emphasized, highlighting predominant actions solving crucial issues, anti-bacterial, remineralization, tissue abilities. addition an emphasis synthesis nanostructures, nano-therapeutic solutions sources are discussed, including natural (plant, animal, marine)-based other synthetic (organic- inorganic-) architectures, Finally, summarize article interesting outlook overcoming challenges translating platforms clinics.
Язык: Английский
Процитировано
1
Regenerative Biomaterials, Год журнала: 2024, Номер 11
Опубликована: Янв. 1, 2024
Abstract Triple-negative breast cancer (TNBC) has emerged as one of the dreadful metastatic tumors in women due to complexity, specificity and high recurrence, resulting poor therapeutic outcomes requiring real-time monitoring for improved theranostics. Despite success efficient radiosensitizers computed tomography (CT)-based contrast agents, bismuth (Bi)-based composites suffer from colloidal stability, dose-dependent toxicity pharmacokinetic shortcomings, leading monitoring. In addition, several small molecule-based therapeutics, including nanoparticle-based delivery systems, limitations acquired multidrug resistance by cells, depriving needs. To overcome this aspect, study demonstrates fabrication drug-like/drugless nanoarchitectures based on copper sulfide-nanoplated oxide (Bi2O3@CuS, shortly BC) theranostic efficacy against TNBC. These systematically characterized BC nanocomposites exhibited pH-/near-infrared (NIR, 808 nm) light-responsive degradability toward dual modal therapies. Due band transition Cu species, designed displayed exceptional photothermal (PTT) conversion efficiency localized PTT effects. addition pH-/NIR-responsiveness, internally overexpressed glutathione (GSH)-responsiveness facilitated release Cu2+ species chemodynamic therapy (CDT)-based end, Bi3+ core could be fully hydrated acidic tumor microenvironment, GSH depletion reducing CDT-induced reactive oxygen clearance, thereby ablating tumors. The acid-responsive CuS resulted intratumoral enrichment BC, demonstrating remarkable CT imaging vivo. Together, these pH-/NIR-/GSH-responsive biodegradable realize integrated PTT/CDT/CT theranostics carcinoma.
Язык: Английский
Процитировано
1
Inorganic Chemistry Communications, Год журнала: 2024, Номер 170, С. 113214 - 113214
Опубликована: Сен. 23, 2024
Язык: Английский
Процитировано
0