ACS Omega,
Год журнала:
2024,
Номер
9(49), С. 48642 - 48649
Опубликована: Ноя. 25, 2024
Oxidative
stress
and
inflammation
are
key
pathological
features
of
atherosclerotic
plaques.
Numerous
nanomedicines
have
been
developed
to
alleviate
oxidative
reduce
within
However,
nonbioactive
carrier
materials
the
bioavailability
may
pose
potential
biological
toxicity.
In
this
study,
we
utilized
unique
amphiphilic
chemical
structure
lipoic
acid
(LA)
prepare
LA
nanoparticles
(LA
NPs)
via
a
self-assembly
method.
Leveraging
inherent
anti-inflammatory
antioxidant
properties
LA,
these
NPs
were
used
for
treatment
atherosclerosis.
an
inflammatory
macrophage
model,
exhibited
superior
activity
compared
free
LA.
Through
ultrasound
imaging
methods,
discovered
that
demonstrated
nice
antiatherosclerotic
effects
in
mice
model.
Immunofluorescence
analysis
further
indicated
associated
with
alleviation
plaques,
reduced
infiltration,
downregulation
cytokine
levels.
Therefore,
offer
promising
therapeutic
strategy
International Journal of Smart and Nano Materials,
Год журнала:
2024,
Номер
15(3), С. 610 - 651
Опубликована: Июль 2, 2024
Atherosclerosis
is
a
severe
cardiovascular
disease
followed
by
the
accumulation
of
atherosclerotic
plaques
within
lumen
blood
vessels
resulting
in
reduced
flow
thus
initiating
series
events.
Conventional
therapies
for
atherosclerosis
encounter
multiple
challenges,
especially
difficulty
precisely
concentrating
certain
affected
regions
and
potential
unwanted
side
effects.
Consequently,
scientists
are
focused
on
developing
nanoformulations
diagnosis
therapy.
Peptide-based
nanomedicines
improve
conventional
offering
improved
structural
therapeutic
stability
enabling
target-specific
delivery.
Their
inherent
biocompatibility
biodegradability
additionally
render
them
desirable
materials
intended
vivo
use.
This
review
manuscript
aims
to
provide
an
in-depth
overview
peptide-based
atherosclerosis,
focusing
targeted
cells
like
endothelial
cells,
macrophages,
monocytes
their
interaction
with
different
plaque
components.
Moreover,
also
highlights
latest
progress
multimodal
techniques
provides
comprehensive
limitations
associated
practical
implementation.
ACS Omega,
Год журнала:
2024,
Номер
9(49), С. 48642 - 48649
Опубликована: Ноя. 25, 2024
Oxidative
stress
and
inflammation
are
key
pathological
features
of
atherosclerotic
plaques.
Numerous
nanomedicines
have
been
developed
to
alleviate
oxidative
reduce
within
However,
nonbioactive
carrier
materials
the
bioavailability
may
pose
potential
biological
toxicity.
In
this
study,
we
utilized
unique
amphiphilic
chemical
structure
lipoic
acid
(LA)
prepare
LA
nanoparticles
(LA
NPs)
via
a
self-assembly
method.
Leveraging
inherent
anti-inflammatory
antioxidant
properties
LA,
these
NPs
were
used
for
treatment
atherosclerosis.
an
inflammatory
macrophage
model,
exhibited
superior
activity
compared
free
LA.
Through
ultrasound
imaging
methods,
discovered
that
demonstrated
nice
antiatherosclerotic
effects
in
mice
model.
Immunofluorescence
analysis
further
indicated
associated
with
alleviation
plaques,
reduced
infiltration,
downregulation
cytokine
levels.
Therefore,
offer
promising
therapeutic
strategy
