Abstract
Osteoarthritis
(OA)
is
a
progressively
developing
condition
primarily
characterized
by
the
deterioration
of
articular
cartilage
and
proliferation
bone,
along
with
ongoing
inflammation.
Although
precise
pathogenesis
remains
somewhat
elusive,
restoring
homeostatic
balance
intra‐articular
microenvironment
crucial
for
management
OA.
Intra‐articular
injection
medication
one
most
direct
effective
treatment
methods;
however,
injectable
drugs
used
osteoarthritis
treatment,
due
to
their
rapid
breakdown,
quick
release,
poor
biological
activity,
frequent
injections,
leading
increased
risk
infection
suboptimal
therapeutic
outcomes.
In
this
study,
lubricating
dual‐responsive
hydrogel
based
on
zeolitic
imidazolate
frameworks‐8
(ZIF‐8)
impregnated
Quercetin
(Que)
designed,
which
can
facilitate
OA
remodeling
microenvironment.
The
prepared
nanocomposite
(MH/CCM@ZIF‐8@Que)
exhibits
pH
reactive
oxygen
species
(ROS)
responsiveness,
alongside
controllable
release
bioactive
substances
modulate
bone
tissue,
thereby
mitigating
synovitis
degeneration
matrix,
while
simultaneously
facilitating
repair.
This
developed
thermosensitive
hydrogel,
effectively
balances
lubrication
controlled
substances,
represents
highly
promising
approach
osteoarthritis.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 14, 2024
Abstract
Osteoarthritis
(OA)
is
an
inflammatory
and
progressive
joint
disease
characterized
by
angiogenesis‐mediated
sustained,
chronic,
low‐grade
synovitis.
Anti‐angiogenesis
emerging
as
a
strategy
for
attenuating
OA
progression,
but
often
compromised
poor
targeted
drug
delivery
immune
clearance.
Recent
studies
have
identified
macrophages
formed
“protective
barrier”
in
the
lining
layer
(LL)
of
synovium,
which
blocked
communication
cavity
sublining
(SL)
synovium.
Inspired
natural
mimicry,
macrophage
membrane‐camouflaged
explored
to
avoid
Based
on
single
cell
RNA
sequencing,
CD34
+
synovial
cells
are
“sentinel
cells”
synovium
angiogenesis.
Consequently,
antibody‐modified
membrane
constructed
target
new
Hence,
biomimetic
multi‐layered
nanoparticle
(NP)
developed
that
incorporates
axitinib‐loaded
poly(lactic‐co‐glycolic)
acid
(PLGA)
with
antibody
modified
(Atb@NP@Raw@CD34)
specifically
deliver
axitinib
(Atb)
SL
sustain
inhibiting
angiogenesis
without
elimination.
It
found
Atb@NP@Raw@CD34
can
pass
through
“barrier”,
targeting
cells,
continuously
releasing
Atb
anti‐angiogenesis
Furthermore,
vivo
data
demonstrated
attenuate
degeneration
In
conclusion,
local
injection
presents
promising
approach
clinically
impeding
progression.
Journal of Biomaterials Science Polymer Edition,
Год журнала:
2024,
Номер
unknown, С. 1 - 16
Опубликована: Окт. 26, 2024
Restoring
cartilage
to
healthy
state
is
challenging
due
low
cell
density
and
hence
regenerative
capacity.
The
current
platforms
are
not
compatible
with
clinical
translation
require
dedicated
handling
of
trained
personnel.
However,
by
engineering
implanting
microaggregates
in
higher
concentrations,
efficient
formation
new
can
be
achieved,
even
the
absence
exogenous
growth
factors.
Therefore,
one-step
surgeries
preferable
for
novel
treatments
we
need
laden
microgels
allowing
microaggregaets
ACS Sensors,
Год журнала:
2024,
Номер
9(11), С. 6060 - 6070
Опубликована: Ноя. 4, 2024
Chronic
diseases,
including
diabetes,
cardiovascular
and
microvascular
complications,
contribute
significantly
to
global
morbidity
mortality.
Current
monitoring
tools
such
as
glucometers
continuous
glucose
monitors
only
measure
one
analyte;
multiplexing
technologies
offer
a
promising
approach
for
multiple
biomarkers,
enabling
the
management
of
comorbidities
providing
more
comprehensive
disease
insights.
In
this
work,
we
describe
miniaturized
optical
"barcode"
sensor
with
high
biocompatibility
oxygen.
This
enzymatic
relies
on
oxygen
consumption
in
proportion
local
levels
phosphorescence
reporting
tissue
lifetime-based
probe.
The
was
specifically
designed
operate
environment
low
dissolved
barcode
consists
poly(ethylene
glycol)
diacrylate
(PEGDA)
hydrogel
four
discrete
compartments
separately
filled
glucose-
or
oxygen-sensing
phosphorescent
microparticles.
We
evaluated
response
hydrogels
fluctuating
over
physiological
range
under
conditions,
demonstrating
controlled
tuning
dynamic
sensitivity.
Moreover,
exhibited
remarkable
storage
stability
12
weeks,
along
full
reversibility
excellent
reproducibility
(∼6%
variability
lifetime)
nearly
50
devices.
Electron
beam
sterilization
had
negligible
effect
sensors.
Furthermore,
our
investigation
revealed
minimal
lifetime
changes
while
exhibiting
increased
glucose-responsive
when
subjected
alternating
concentrations
(0
200
mg/dL),
showcasing
sensor's
multianalyte
sensing
capabilities
without
crosstalk
between
compartments.
Additionally,
evaluation
chronic
sensors
inserted
pigs
appropriate
barcodes
well
material
many
months.
These
findings
support
further
development
similar
introducing
assays
biomarkers
that
can
provide
on-demand
feedback
individuals
manage
conditions.
Abstract
Osteoarthritis
(OA)
is
a
progressively
developing
condition
primarily
characterized
by
the
deterioration
of
articular
cartilage
and
proliferation
bone,
along
with
ongoing
inflammation.
Although
precise
pathogenesis
remains
somewhat
elusive,
restoring
homeostatic
balance
intra‐articular
microenvironment
crucial
for
management
OA.
Intra‐articular
injection
medication
one
most
direct
effective
treatment
methods;
however,
injectable
drugs
used
osteoarthritis
treatment,
due
to
their
rapid
breakdown,
quick
release,
poor
biological
activity,
frequent
injections,
leading
increased
risk
infection
suboptimal
therapeutic
outcomes.
In
this
study,
lubricating
dual‐responsive
hydrogel
based
on
zeolitic
imidazolate
frameworks‐8
(ZIF‐8)
impregnated
Quercetin
(Que)
designed,
which
can
facilitate
OA
remodeling
microenvironment.
The
prepared
nanocomposite
(MH/CCM@ZIF‐8@Que)
exhibits
pH
reactive
oxygen
species
(ROS)
responsiveness,
alongside
controllable
release
bioactive
substances
modulate
bone
tissue,
thereby
mitigating
synovitis
degeneration
matrix,
while
simultaneously
facilitating
repair.
This
developed
thermosensitive
hydrogel,
effectively
balances
lubrication
controlled
substances,
represents
highly
promising
approach
osteoarthritis.
