Journal of the American Chemical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 27, 2024
The
development
of
photoswitches
that
absorb
low
energy
light
is
notable
interest
due
to
the
growing
demand
for
smart
materials
and
therapeutics
necessitating
benign
stimuli.
Donor–acceptor
Stenhouse
adducts
(DASAs)
are
molecular
respond
in
visible
near-infrared
spectrum.
As
a
result
their
modular
assembly,
DASAs
can
be
modified
at
donor,
acceptor,
triene,
backbone
heteroatom
compartments
tuning
optical
photoswitching
properties.
This
Perspective
focuses
on
electronic
steric
contributions
each
compartment
how
they
influence
photophysical
properties
through
adjustment
isomerization
energetic
landscape.
An
emphasis
current
synthetic
strategies
limitations
highlights
opportunities
DASA
architecture,
thus
property
expansion.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Дек. 23, 2024
Cyanine
dye-containing
nanoparticles
have
widely
been
used
in
"all-in-one"
NIR
fluorescence
imaging
(FI)-guided
photothermal
therapy
(PTT)
because
of
their
intrinsically
large
extinction
coefficient
and
available
physical
chemical
modulation
methods
to
tune
absorption
emission
wavelengths.
The
combination
good
brightness
excellent
tumor-targeting
capacity
is
the
key
realize
efficient
NIR-II
FI-guided
PTT.
In
this
study,
by
covalently
decorating
absorptive
cyanine
dyes
with
bulky
AIE
motify,
we
demonstrate
how
steric
hindrance
suppresses
π-π
stacking-induced
quenching
contributes
FI
subcutaneous
glioblastoma.
resulting
dye
(C12-TPAE)
5
times
brighter
than
original
formulated
liposomal
C12-TPAE-AL
has
a
high
conversion
efficiency
62.4%,
colloidal
light
stability.
Importantly,
ApoE
peptide
absorbed
on
surface,
yielding
lipoprotein-mimicking
nanoparticles,
which
achieve
active
targeting
glioblastoma
PTT
without
tumor
recurrence
any
side
effects
normal
organs
(heart,
kidneys,
liver,
spleen,
or
lung).
This
research
highlights
facile
design
route
for
bright
emissive
indicates
that
biomimetic
theranostic
nanoplatforms
are
promising
candidates
future
precision
therapy.
Chemosensors,
Год журнала:
2024,
Номер
12(7), С. 138 - 138
Опубликована: Июль 11, 2024
Organic
fluorescent
probes
have
attracted
attention
for
bioimaging
due
to
their
advantages,
including
high
sensitivity,
biocompatibility,
and
multi-functionality.
However,
some
limitations
related
low
signal-to-background
ratio
false
positive
negative
signals
make
them
difficult
in
situ
target
detection.
Recently,
organelle
targeting
self-assembled
been
studied
meet
this
demand.
Most
of
the
dye
molecules
suffer
from
a
quenching
effect,
but,
specifically,
dyes
like
Pyrene,
Near-Infrared
(NIR),
Nitrobenzoxadiazole
(NBD),
Fluorescein
isothiocyanate
(FITC),
Naphthalenediimides
(NDI),
Aggregation
induced
emission
(AIE)
show
unique
characteristics
when
they
undergo
self-assembly
or
aggregation.
Therefore,
review,
we
classified
according
type
provided
an
overview
organelle-targeting
strategy
with
emphasis
on
construction
nanostructures
within
complex
cellular
environments.
Results
demonstrated
that
effectively
localized
inside
organelles
(mitochondria,
lysosome,
golgi
body)
form
various
possess
bio-functionality
long
retention
time,
membrane
disruption/ROS
generation/enzyme
activity
suppression
ability,
enhanced
photodynamic
properties
anticancer
treatment.
Furthermore,
systematically
discussed
challenges
remain
be
resolved
performance
these
mentioned
future
directions
design
molecules.
