Journal of the American Chemical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 27, 2024
The
development
of
photoswitches
that
absorb
low
energy
light
is
notable
interest
due
to
the
growing
demand
for
smart
materials
and
therapeutics
necessitating
benign
stimuli.
Donor–acceptor
Stenhouse
adducts
(DASAs)
are
molecular
respond
in
visible
near-infrared
spectrum.
As
a
result
their
modular
assembly,
DASAs
can
be
modified
at
donor,
acceptor,
triene,
backbone
heteroatom
compartments
tuning
optical
photoswitching
properties.
This
Perspective
focuses
on
electronic
steric
contributions
each
compartment
how
they
influence
photophysical
properties
through
adjustment
isomerization
energetic
landscape.
An
emphasis
current
synthetic
strategies
limitations
highlights
opportunities
DASA
architecture,
thus
property
expansion.
Abstract
Cyanine‐based
near‐infrared
(NIR)
fluorescent
probes
have
played
vital
roles
in
biological
application
due
to
their
low
interference
from
background
fluorescence,
deep
tissue
penetration,
high
sensitivity,
and
minimal
photodamage
samples.
They
are
widely
utilized
molecular
recognition,
medical
diagnosis,
biomolecular
detection,
imaging.
Herein,
we
provide
a
review
of
recent
advancements
cyanine‐based
NIR
for
the
detection
pH,
cells,
tumor
as
well
photothermal
therapy
(PTT)
photodynamic
(PDT).
Fluorescence
imaging
in
the
second
near-infrared
region
(NIR-II,
1000-1700
nm)
has
garnered
considerable
attention
for
displaying
biological
information
of
deep
tissues.
However,
lack
biocompatible
contrast
agents
with
bright
NIR-II
emission
hampered
precise
clinical
application
tissue
imaging.
Here,
a
lipophilic
enhancement
strategy
employing
donor-acceptor-donor
(D-A-D)
molecules,
introducing
long
alkoxy
chains
and
quaternary
ammonium
salts
development
highly
water-soluble
fluorophores
(BBTD-2C-N),
is
described.
Notably,
liposome-encapsulated
BBTD-2C-N
nanoparticles
(B-2C-N/DMPC)
aqueous
solution
exhibit
1.8-fold
increase
fluorescence
brightness
compared
to
free
methanol.
Avoidance
aggregation-caused
quenching
effect
enhanced
are
attributed
significantly
attenuated
π-π
stacking
interactions
maintained
monodisperses
hydrophobic
liposome
shell.
Moreover,
demonstrates
superior
performance
visualizing
lipid
droplet-rich
HeLa
cells
vitro,
as
well
monitoring
adipose
fatty
liver
vivo.
This
study
reveals
new
avenue
vivo
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 27, 2024
The
development
of
photoswitches
that
absorb
low
energy
light
is
notable
interest
due
to
the
growing
demand
for
smart
materials
and
therapeutics
necessitating
benign
stimuli.
Donor–acceptor
Stenhouse
adducts
(DASAs)
are
molecular
respond
in
visible
near-infrared
spectrum.
As
a
result
their
modular
assembly,
DASAs
can
be
modified
at
donor,
acceptor,
triene,
backbone
heteroatom
compartments
tuning
optical
photoswitching
properties.
This
Perspective
focuses
on
electronic
steric
contributions
each
compartment
how
they
influence
photophysical
properties
through
adjustment
isomerization
energetic
landscape.
An
emphasis
current
synthetic
strategies
limitations
highlights
opportunities
DASA
architecture,
thus
property
expansion.
