Free gas micro-/nano-bubble water: a novel dispersion system to prepare ultrasound imaging vehicles DOI Creative Commons
Jin Lü, Zhen Yang, Xu Wang

и другие.

Biomedical Engineering / Biomedizinische Technik, Год журнала: 2025, Номер unknown

Опубликована: Март 28, 2025

Abstract Objectives Free gas micro-/nano-bubbles (MNBs) in water have demonstrated significant potential various industrial applications, including treatment, enhanced transport processes, and disinfection. However, the feasibility of utilizing MNBs as a dispersed system for preparing ultrasound imaging vehicles is seldom explored. This study aims to investigate this purpose. Methods Initially, containing sulfur hexafluoride (SF 6 ) was prepared characterized. Subsequently, SF form lipid-shelled bubbles evaluated. involved incubation lyophilized phospholipids with water. Results The confirmed presence Through process, it possible obtain nano-sized narrow size distribution. These exhibited comparable echogenicity those produced by conventional mechanical agitation methods during initial 5 min vitro observation. Conclusions represents novel dispersion medium generating bubbles. approach offers promising new method extravascular drug delivery, potentially expanding applications medical therapeutic delivery systems.

Язык: Английский

Free gas micro-/nano-bubble water: a novel dispersion system to prepare ultrasound imaging vehicles DOI Creative Commons
Jin Lü, Zhen Yang, Xu Wang

и другие.

Biomedical Engineering / Biomedizinische Technik, Год журнала: 2025, Номер unknown

Опубликована: Март 28, 2025

Abstract Objectives Free gas micro-/nano-bubbles (MNBs) in water have demonstrated significant potential various industrial applications, including treatment, enhanced transport processes, and disinfection. However, the feasibility of utilizing MNBs as a dispersed system for preparing ultrasound imaging vehicles is seldom explored. This study aims to investigate this purpose. Methods Initially, containing sulfur hexafluoride (SF 6 ) was prepared characterized. Subsequently, SF form lipid-shelled bubbles evaluated. involved incubation lyophilized phospholipids with water. Results The confirmed presence Through process, it possible obtain nano-sized narrow size distribution. These exhibited comparable echogenicity those produced by conventional mechanical agitation methods during initial 5 min vitro observation. Conclusions represents novel dispersion medium generating bubbles. approach offers promising new method extravascular drug delivery, potentially expanding applications medical therapeutic delivery systems.

Язык: Английский

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