Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 247, С. 114453 - 114453
Опубликована: Дек. 10, 2024
Язык: Английский
Advanced Functional Materials, Год журнала: 2024, Номер 34(48)
Опубликована: Июль 25, 2024
Abstract Cellulose consists of a natural, rigid polymer that is widely used to improve the mechanical and water‐holding properties hydrogels. However, its abundant hydroxyl groups make it highly absorbent free water, leading swelling behavior. This increased water content will also decrease adhesive performance. In this study, cellulose successfully hydrophobically modified reduce absorption water. Gelatin then cross‐linked with through Schiff‐base reaction, resulting in bound content. significantly enhances resistance permeability, improves freeze–thaw stability hydrogel. Due internal hydrophobicity, molecules can quickly penetrate into interior, reducing their residence time on hydrogel surface. allows maintain high adhesion natural environments, achieving an strength up 3.0 MPa wood bamboo‐based materials. The retain even after prolonged exposure humid environment. Additionally, Na + ions enhance electrical conductivity sensitivity (gauge factor (GF) = 1.51), demonstrating potential applications flexible sensing.
Язык: Английский
Процитировано
22
Bioactive Materials, Год журнала: 2024, Номер 37, С. 106 - 118
Опубликована: Март 19, 2024
Effective control of post-extraction hemorrhage and alveolar bone resorption is critical for successful extraction socket treatment, which remains an unmet clinical challenge. Herein, injectable Tetra-PEG hydrogel that possesses rapid gelation, firm tissue adhesion, high mechanical strength, suitable degradability, excellent biocompatibility developed as a sutureless coagulation-independent bioadhesive the management sockets. Our results demonstrate robust adhesive sealing by can provide reliable protection underlying wound stabilize blood clots to facilitate healing.
Язык: Английский
Процитировано
15
Polymer, Год журнала: 2024, Номер 311, С. 127482 - 127482
Опубликована: Авг. 10, 2024
Язык: Английский
Процитировано
4
Biomacromolecules, Год журнала: 2025, Номер unknown
Опубликована: Фев. 5, 2025
Diabetic wound healing remains a significant challenge due to complex pathological mechanisms, including prolonged inflammation, excessive reactive oxygen species (ROS) accumulation, angiogenesis dysfunction, and increased susceptibility bacterial infection. In this study, we developed dual ROS/glucose-responsive quercetin-loaded supramolecular hydrogel (GPQ hydrogel) for treating diabetic wounds. The was fabricated by incorporating quercetin (QUE) into guanosine–phenylboronic acid (GP) network through dynamic borate ester bonds. Structural characterization revealed the formation of typical G-quadruplex structure in GPQ hydrogel. responsiveness ROS glucose enabled controlled release QUE, effectively addressing abnormal microenvironment diabetes. vitro studies demonstrated excellent antibacterial, antioxidant, anti-inflammatory, pro-angiogenic properties Furthermore, vivo study using full-thickness model streptozotocin-induced rats showed that significantly accelerated closure, enhanced re-epithelialization collagen deposition, promoted compared control GP groups. Immunofluorescence analysis confirmed superior antioxidant effects microenvironment. This presents promising multifunctional biomaterial managing
Язык: Английский
Процитировано
0
Deleted Journal, Год журнала: 2025, Номер 9(1)
Опубликована: Март 4, 2025
Tooth extraction, while essential for oral health, can contribute to systemic complications, particularly increasing cardiovascular risk due bacterial translocation and inflammation. Periodontal disease, a major cause of tooth loss, exacerbates this by serving as reservoir pathogenic bacteria that enter the bloodstream during extractions. This review explores mechanisms linking post-extraction infections diseases evaluates role nanotechnology in mitigating these risks. Advances antimicrobial nanoparticles, nanodrug delivery systems, biosensors offer promising solutions infection control targeted drug delivery. These innovations enhance healing potentially reducing However, challenges remain optimizing material biocompatibility, ensuring clinical efficacy, addressing translational hurdles. underscores need interdisciplinary research integrate into dental practice, ultimately improving both health outcomes.
Язык: Английский
Процитировано
0
Biomaterials Advances, Год журнала: 2025, Номер 173, С. 214280 - 214280
Опубликована: Март 9, 2025
Язык: Английский
Процитировано
0
MedComm, Год журнала: 2025, Номер 6(4)
Опубликована: Март 22, 2025
Abstract Wound healing remains a critical global healthcare challenge, with an annual treatment cost exceeding $50 billion worldwide. Over the past decade, significant advances in wound care have focused on developing sophisticated biomaterials that promote tissue regeneration and prevent complications. Despite these developments, there crucial need for multifunctional materials can effectively address complex, multiphase nature of repair while being effective easily applicable various clinical settings. This review systematically analyzes latest developments materials, examining their chemical composition, structural design, therapeutic mechanisms. We comprehensively evaluate bioactive components, including natural polymers, synthetic matrices, hybrid composites, along different forms, such as hydrogels, powders, smart dressings. Special attention is given to emerging strategies material design integrate multiple functions, sustained drug delivery, infection prevention, promotion. The insights provided this illuminate path toward next‐generation highlighting opportunities more solutions significantly improve patient outcomes reduce burden.
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Март 24, 2025
Bacterial infection gives rise to a hypoxic, H2O2-abundant, and acidic local microenvironment at the site of inflammation, which prevents healing skin tissues. In this work, gelatin oxidized carboxymethyl cellulose were developed as framework hydrogels. Tannic acid 3-formylphenylboronic served small-molecule anchors. Through introduction multiple dynamic cross-linkings, hydrogel was endowed with various functions. These functions encompassed mechanical compatibility skin, reversible adhesion characteristics, rapid self-healing capabilities. addition, nanoflower-like MnO2 microparticles loaded berberine hydrochloride embedded. has ability not only kill bacteria through photothermal effect (PTT) but also catalyze decomposition H2O2 release oxygen, effectively improving inflammatory microenvironment. Remarkably, based on drug/PTT synergistic strategy, exhibited significant antibacterial activity biofilm removal under mild conditions (<50 °C), avoiding thermal damage healthy Consequently, hydrogels demonstrate favorable biocompatibility, cell proliferation, migration, angiogenesis, collagen deposition, tissue regeneration. Therefore, multifunctional antimicrobial is expected be skin-friendly medical dressing enormous potential in treatment soft infections.
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 9, 2025
Abstract The double‐network (DN) structure has been proven to be an effective approach enhancing the strength and stretchability of stretchable ionic conductors. However, conventional strategy using a rigid first network encapsulate loose second often suffers from insufficient poor stability in practical applications due presence solvents system or significant compatibility differences between two networks. Therefore, developing ion‐conductive elastomers with minimal strong environmental is critical addressing these challenges flexible electronics. This study leverages highly customizable all‐solid‐state supramolecular deep eutectic polymers design Poly ( N ‐(2‐Hydroxyethyl) acrylamide‐Choline chloride) (HEAA‐ChCl) as Poly(Acrylic acid‐Choline (AA‐ChCl) network, both exhibiting similar compatibility. ensures uniform embedding networks, enabling efficient energy dissipation under external forces. resulting elastomer achieves 13.8 MPa, tensile strain 2780%, toughness high 161 MJ m − 3 . Such strategy, its exceptional mechanical properties, provides robust support for advancing high‐strength intelligent manufacturing.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162931 - 162931
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0