Extracellular matrix-inspired biomaterials for wound healing
Molecular Biology Reports,
Год журнала:
2024,
Номер
51(1)
Опубликована: Июль 22, 2024
Diabetic
foot
ulcers
(DFU)
are
a
debilitating
and
life-threatening
complication
of
Diabetes
Mellitus.
Ulceration
develops
from
combination
associated
diabetic
complications,
including
neuropathy,
circulatory
dysfunction,
repetitive
trauma,
they
affect
approximately
19-34%
patients
as
result.
The
severity
chronic
nature
stems
the
disruption
to
normal
wound
healing,
result
molecular
mechanisms
which
underly
pathophysiology.
current
standard-of-care
is
clinically
insufficient
promote
healing
for
many
DFU
patients,
resulting
in
high
frequency
recurrence
limb
amputations.
Biomaterial
dressings,
particular
those
derived
extracellular
matrix
(ECM),
have
emerged
promising
approach
treatment
DFU.
By
providing
template
cell
infiltration
skin
regeneration,
ECM-derived
biomaterials
offer
great
hope
A
range
approaches
exist
development
biomaterials,
use
purified
ECM
components,
decellularisation
processing
donor/
animal
tissues,
or
vitro-deposited
ECM.
This
review
discusses
assessment
wounds,
well
action
through
stimulate
healing.
Язык: Английский
Lymph Node-on-Chip Technology: Cutting-Edge Advances in Immune Microenvironment Simulation
Pharmaceutics,
Год журнала:
2024,
Номер
16(5), С. 666 - 666
Опубликована: Май 16, 2024
Organ-on-a-chip
technology
is
attracting
growing
interest
across
various
domains
as
a
crucial
platform
for
drug
screening
and
testing
set
to
play
significant
role
in
precision
medicine
research.
Lymph
nodes,
being
intricately
structured
organs
essential
the
body’s
adaptive
immune
responses
antigens
foreign
particles,
are
pivotal
assessing
immunotoxicity
of
novel
pharmaceuticals.
Significant
progress
has
been
made
research
on
structure
function
lymphatic
system.
However,
there
still
an
urgent
need
develop
prospective
tools
techniques
delve
deeper
into
its
diseases’
pathological
physiological
processes
corresponding
immunotherapeutic
therapies.
Organ
chips
can
accurately
reproduce
specific
functional
areas
lymph
nodes
better
simulate
complex
microstructure
interactions
between
different
cells,
which
convenient
studying
biological
processes.
This
paper
reviews
existing
node
their
design
approaches.
It
discusses
applications
above
systems
modeling
cell
motility,
cell–cell
interactions,
vaccine
responses,
testing,
cancer
Finally,
we
summarize
challenges
that
current
faces
terms
structure,
source,
extracellular
matrix
simulation
provide
outlook
future
direction
integrated
system
chips.
Язык: Английский
Engineering cell-derived extracellular matrix for peripheral nerve regeneration
Materials Today Bio,
Год журнала:
2024,
Номер
27, С. 101125 - 101125
Опубликована: Июнь 13, 2024
Extracellular
matrices
(ECMs)
play
a
key
role
in
nerve
repair
and
are
recognized
as
the
natural
source
of
biomaterials.
In
parallel
to
extensively
studied
tissue-derived
ECMs
(ts-ECMs),
cell-derived
(cd-ECMs)
also
have
capability
partially
recapitulate
complicated
regenerative
microenvironment
native
tissues.
Notably,
cd-ECMs
can
avoid
shortcomings
ts-ECMs.
Cd-ECMs
be
prepared
by
culturing
various
cells
or
even
autologous
vitro
under
pathogen-free
conditions.
And
mild
decellularization
achieve
efficient
removal
immunogenic
components
cd-ECMs.
Moreover,
more
readily
customizable
desired
functional
properties.
These
advantages
garnered
significant
attention
for
potential
neuroregenerative
medicine.
As
promising
biomaterials,
bring
new
hope
effective
treatment
peripheral
injuries.
Herein,
this
review
comprehensively
examines
current
knowledge
about
characteristics
their
mechanisms
interaction
with
regeneration,
particular
focus
on
preparation,
engineering
optimization,
scalability
The
applications
from
distinct
cell
sources
reported
tissue
highlighted
summarized.
Furthermore,
limitations
that
should
addressed
outlooks
related
clinical
translation
put
forward
well.
Язык: Английский