A Comprehensive Review of Nanoparticle-Based Drug Delivery for Modulating PI3K/AKT/mTOR-Mediated Autophagy in Cancer
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 1868 - 1868
Опубликована: Фев. 21, 2025
The
phosphoinositide
3-kinase
(PI3K)/AKT/mammalian
target
of
the
rapamycin
(mTOR)
pathway
plays
a
crucial
role
in
regulation
autophagy,
cellular
mechanism
vital
for
homeostasis
through
degradation
damaged
organelles
and
proteins.
dysregulation
this
is
significantly
associated
with
cancer
progression,
metastasis,
resistance
to
therapy.
Targeting
PI3K/AKT/mTOR
signaling
presents
promising
strategy
treatment;
however,
traditional
therapeutics
frequently
encounter
issues
related
nonspecific
distribution
systemic
toxicity.
Nanoparticle-based
drug
delivery
systems
represent
significant
advancement
addressing
these
limitations.
Nanoparticles
enhance
bioavailability,
stability,
targeted
therapeutic
agents,
facilitating
precise
modulation
autophagy
cells.
Functionalized
nanoparticles,
such
as
liposomes,
polymeric
metal-based
nanocarriers,
facilitate
tumor
tissues,
minimizing
off-target
effects
improving
efficacy.
These
can
deliver
multiple
agents
concurrently,
enhancing
PI3K/AKT/mTOR-mediated
oncogenic
pathways.
This
review
examines
advancements
nanoparticle-mediated
that
pathway,
emphasizing
their
contribution
precision
side
integration
nanotechnology
molecularly
therapies
substantial
potential
resistance.
Future
initiatives
must
prioritize
optimization
clinical
translation
patient
outcomes.
Язык: Английский
Nanoparticles, a promising treatment for gastric cancer
Smart Materials in Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Breaking barriers: Smart vaccine platforms for cancer immunomodulation
Cancer Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 3, 2025
Abstract
Despite
significant
advancements
in
cancer
treatment,
current
therapies
often
fail
to
completely
eradicate
malignant
cells.
This
shortfall
underscores
the
urgent
need
explore
alternative
approaches
such
as
vaccines.
Leveraging
immune
system's
natural
ability
target
and
kill
cells
holds
great
therapeutic
potential.
However,
development
of
vaccines
is
hindered
by
several
challenges,
including
low
stability,
inadequate
response
activation,
immunosuppressive
tumor
microenvironment,
which
limit
their
efficacy.
Recent
progress
various
fields,
click
chemistry,
nanotechnology,
exosome
engineering,
neoantigen
design,
offer
innovative
solutions
these
challenges.
These
achievements
have
led
emergence
smart
vaccine
platforms
(SVPs),
integrate
protective
carriers
for
messenger
ribonucleic
acid
(mRNA)
with
functionalization
strategies
optimize
targeted
delivery.
Click
chemistry
further
enhances
SVP
performance
improving
encapsulation
mRNA
antigens
facilitating
precise
delivery
review
highlights
latest
developments
technologies
therapy,
exploring
both
opportunities
challenges
advancing
transformative
approaches.
Язык: Английский
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
Tamanna Binte Huq,
Punnya Anil Kumar Jeeja,
Sudip Kumar Dam
и другие.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 10, 2025
Abstract
Gene
therapy
offers
transformative
potential
for
treating
genetic
disorders
by
directly
addressing
the
molecular
root
causes
of
diseases.
However,
primary
challenges
gene
involve
efficient
delivery
therapeutic
material
to
target
cells,
crossing
biological
barriers,
managing
toxicity
and
immune
responses.
Mesoporous
silica
nanoparticles
(MSNs),
due
their
unique
structural
features
have
emerged
as
a
promising
platform
overcome
these
challenges.
In
recent
years,
MSNs
gained
significant
attention
nanocarriers
various
nucleic
acids.
This
review
comprehensively
examines
role
in
therapy,
focusing
on
capabilities
targeted
siRNA,
DNA,
CRISPR‐Cas
systems,
other
therapeutics.
work
explores
modern
advancements
synthesis
functionalization
strategies
impact
modifications
stability,
cellular
uptake,
controlled
release
under
physiological
conditions.
Additionally,
highlights
use
develop
theranostic
where
is
combined
with
diagnostic
imaging
real‐time
monitoring
personalized
treatment
strategies.
Finally,
this
discusses
future
perspectives
delivery,
regulatory
challenges,
enhancing
clinical
translation,
expanding
application
cancers.
Язык: Английский
Drug delivery for platinum therapeutics
Journal of Controlled Release,
Год журнала:
2025,
Номер
380, С. 503 - 523
Опубликована: Фев. 11, 2025
Язык: Английский
Advances in Mesoporous Silica Nanoparticles as Carriers for Drug Delivery and other Biomedical Applications
Microporous and Mesoporous Materials,
Год журнала:
2025,
Номер
unknown, С. 113603 - 113603
Опубликована: Март 1, 2025
Язык: Английский
Nanocarriers for cutting-edge cancer immunotherapies
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 15, 2025
Cancer
immunotherapy
aims
to
harness
the
body's
own
immune
system
for
effective
and
long-lasting
elimination
of
malignant
neoplastic
tissues.
Owing
advance
in
understanding
cancer
pathology
immunology,
many
novel
strategies
enhancing
immunological
responses
against
various
cancers
have
been
successfully
developed,
some
translated
into
excellent
clinical
outcomes.
As
one
promising
strategy
next
generation
immunotherapies,
activating
multi-cellular
network
(MCN)
within
tumor
microenvironment
(TME)
deploy
multiple
mechanisms
action
(MOAs)
has
attracted
significant
attention.
To
achieve
this
effectively
safely,
delivering
or
pleiotropic
therapeutic
cargoes
targeted
sites
cancerous
tissues,
cells,
intracellular
organelles
is
critical,
which
numerous
nanocarriers
developed
leveraged.
In
review,
we
first
introduce
payloads
categorized
according
their
predicted
functions
physicochemical
structures
forms.
Then,
nanocarriers,
along
with
unique
characteristics,
properties,
advantages,
limitations,
are
introduced
notable
recent
applications
immunotherapy.
Following
discussions
on
targeting
strategies,
a
summary
each
nanocarrier
matching
suitable
provided
comprehensive
background
information
designing
regimens.
Язык: Английский
Transforming Malignant Tumors into Vulnerable Phenotypes via Nanoscale Coordination Polymer Mediated Cell Senescence and Photodynamic Therapy
Biomaterials,
Год журнала:
2025,
Номер
unknown, С. 123355 - 123355
Опубликована: Апрель 1, 2025
Язык: Английский
Engineering of Nanofibers Embedded with Targeted Nanoparticles Breaks Redox Levers for Glioblastoma Therapy
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 4, 2024
Abstract
Glioblastoma
multiforme
(GBM),
one
of
the
most
aggressive
brain
cancers,
presents
substantial
therapeutic
challenges,
particularly
concerning
postsurgical
recurrence
and
inherent
drug
resistance.
In
this
study,
a
nanofiber‐based
delivery
system
integrating
platinum
pro‐drugs
hemoglobin
into
mesoporous
silica
nanoparticles
(HB/HSPt@MS
NPs)
is
reported,
which
are
surface‐modified
with
poly(ethylene
glycol)
(PEG)
targeting
molecules,
subsequently
embedded
nanofibers
using
an
electrostatic
spinning
approach.
Applied
to
tumor
site,
these
leverage
folate
receptor
overexpression
on
tumor's
redox
state
enable
precise
release,
inducing
cell
death
through
targeted
resistance
pathway.
The
incorporation
crucial
as
it
disrupts
balance
within
GBM
cells
by
facilitating
influx
iron
ions,
leading
lipid
peroxidation
Fenton
reaction.
This
induces
oxidative
stress
overwhelms
cellular
antioxidant
mechanisms.
dual
mechanism
action—direct
cytotoxicity
sustained
release
indirect
induced
stress—enhances
efficacy
drugs.
effectively
bypasses
blood‐brain
barrier
reduces
systemic
toxicity,
significantly
improving
efficacy.
Both
in
vitro
vivo
evaluations
demonstrate
inhibition
growth
recurrence,
highlighting
potential
for
personalized
therapy.
Язык: Английский