Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 13, 2024
Abstract
Severe
skin
wounds
arising
from
burns,
cancers,
and
accidents
can
damage
the
entire
tissue
structure,
resulting
in
permanent
somatosensory
dysfunction
patients.
Although
emerging
hydrogel
dressings
have
shown
clinical
potential
for
accelerating
wound
repair,
use
of
an
individual
material
to
synchronously
restore
structure
sensory
function
defective
remains
a
challenge.
Herein,
multifunctional
that
combines
electroconductive
polydopamine‐capped
graphene
nanosheets
(PrGOs)
embedded
dynamically
crosslinked
dual‐polysaccharide
(xyloglucan
chitosan)
matrix
network
is
presented.
The
fabricated
hydrogels
adjustable
modulus
be
matched
at
site,
owing
dynamic
Schiff‐based
crosslinking
as
well
facile
photo‐triggered
secondary
crosslinking.
Furthermore,
photothermal
activity
PrGO
elevate
local
temperature
up
≈50
°C,
significantly
restraining
bacterial
growth.
These
two
factors
jointly
promote
regeneration
tissue.
Tissue
adhesion
also
reported
offers
conformable
robust
interface
detect
quantify
human
movement
physiological
signals
mimic
system.
This
effective
one‐stone‐for‐two‐birds
simultaneously
achieves
multi‐signal
sensing,
promoting
restoration
and/or
replacement
damaged
skins.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 21, 2025
Multifunctional
hydrogels
have
garnered
significant
interest
but
remain
challenging
due
to
the
complex
preparation
process
and
high
cost
of
raw
materials.
Herein,
bisphenol
A
diglycidyl
ether
(BADGE)
poly(ethylene
glycol)
(PEGDGE)
were
reacted
with
3-amino-1-propanol
via
a
catalyst-free
amine–epoxy
"click"
chemistry,
followed
by
addition
hydrophilic
1,3-propane
sultone
(1,3-PS)
higher
water
content,
then
cross-linked
hexamethylene
diisocyanate
(HDI)
in
one-pot
provide
polymer
network,
i.e.,
PBAxPEGyPU–PS.
The
two-step
cross-linking
method
enables
greater
precision
controlling
density
process.
situ
microphase-separated
porous
PBA50PEG50PU–PS
demonstrates
nanosized
pores
approximately
100
nm
uniform
distribution
thermodynamic
incompatibility,
enabling
superior
mechanical
properties
transparency
87.9%.
Upon
absorption
loss
cycle,
89.7%
was
obtained
lower
pore
50
solvent-induced
self-assembly
its
amphiphilic
structure.
Furthermore,
bilayer
hydrogel
composed
WPBA90PEG10PU–PS
WPBA50PEG50PU–PS
designed
for
"Janus"
soft
actuator
based
on
difference
between
two
sides
swelling
ability
upon
absorption,
which
has
been
applied
underwater
grasping
humidity-responsive
switch.
To
maintain
inherent
elasticity
conductivity
hydrogel,
glycerol
(Gly)
sodium
ion
(Na+)
introduced
into
mixture.
It
shows
that
WPBA50PEG50PU–PS/Gly67
maintains
environmental
stability
more
than
80%
weight
at
20
°C
72
h
additional
frost
resistance
−20
°C,
dual
network
WPBA50PEG50PU–PS/Gly67/Na10
exhibits
best
comprehensive
tensile
strength
good
conductivity.
Meanwhile,
1,3-PS
provides
quaternary
ammonium
salt
sulfobetaine,
endowing
multicomponent
antibacterial
sensing
capabilities.
This
work
versatile
approach
preparing
transparent
multifunctional
highlights
their
potential
various
applications.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Plant
polyphenol-based
hydrogels,
known
for
their
biocompatibility
and
adhesive
properties,
have
emerged
as
promising
materials
in
biomedical
applications.
These
hydrogels
leverage
the
catechol
group's
ability
to
form
stable
bonds
moist
environments,
similar
mussel
proteins.
This
review
provides
a
comprehensive
overview
of
synthesis,
adhesion
mechanisms,
applications,
particularly
wound
healing,
tissue
regeneration,
drug
delivery.
However,
challenges
related
vivo
stability
long-term
remain
critical
barriers
clinical
translation.
Future
research
should
focus
on
enhancing
bioactivity,
biocompatibility,
scalability
these
while
addressing
concerns
toxicity,
immune
responses,
large-scale
manufacturing.
Advances
artificial
intelligence-assisted
screening
3D/4D
bioprinting
are
expected
accelerate
development
Furthermore,
integration
biomimetic
designs
responsive
functionalities,
such
pH
or
temperature
sensitivity,
holds
promise
further
improving
therapeutic
efficacy.
In
conclusion,
multifunctional
plant
represents
frontier
advancing
personalized
medicine
minimally
invasive
treatments.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 9100 - 9100
Опубликована: Авг. 22, 2024
The
impressive
adhesive
capacity
of
marine
mussels
has
inspired
various
fascinating
designs
in
biomedical
fields.
Mussel-inspired
injectable
hydrogels,
as
a
type
promising
mussel-inspired
material,
have
attracted
much
attention
due
to
their
minimally
invasive
property
and
desirable
functions
provided
by
components.
In
recent
decades,
hydrogels
been
designed
widely
applied
numerous
rational
incorporation
catechol
groups
endows
the
with
potential
exhibit
many
properties,
including
tissue
adhesiveness
self-healing,
antimicrobial,
antioxidant
capabilities,
broadening
applications
this
review,
we
first
give
brief
introduction
adhesion
mechanism
characteristics
hydrogels.
Further,
typical
design
strategies
are
summarized.
methodologies
for
integrating
into
polymers
crosslinking
methods
discussed
section.
addition,
systematically
overview
applications,
focus
on
how
unique
properties
these
benefit
challenges
perspectives
last
This
review
may
provide
new
inspiration
novel
bioinspired
facilitate
application
ACS Materials Letters,
Год журнала:
2024,
Номер
6(9), С. 4360 - 4370
Опубликована: Авг. 21, 2024
Diabetic
foot
ulcers
are
a
severe
complication
of
diabetes,
imposing
substantial
burden
on
both
health
and
the
economy.
Bacterial
infections,
high
glucose
levels,
intricate
microenvironment
oxidation
collectively
hinder
healing
diabetic
wounds.
Hydrogels
responsive
to
have
demonstrated
significant
advantages
in
treating
wounds
due
their
ability
release
drugs
demand.
The
study
utilized
modified
pectin
hyaluronic
acid
develop
self-recognizing
self-treating
composite
hydrogel.
Within
this
hydrogel,
insulin
was
encapsulated
using
metal–organic
framework
with
an
ROS-responsive
coating
(ZIF-8@PEG-TK).
Under
low
pH
conditions,
INS@ZIF-8@PEG-TK
released
responded
excess
ROS,
ensuring
sustained
release.
This
hydrogel
exhibited
excellent
antimicrobial
antioxidant
activities
along
biocompatibility.
It
promoted
polarization
macrophages,
reduced
accelerated
cell
proliferation
collagen
deposition,
leading
rapid
wound
closure.
Accordingly,
microenvironment-responsive
is
promising
biomaterial
for
chronic
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 10, 2024
Abstract
The
treatment
of
infected
pressure
ulcers
(IUPs)
requires
addressing
diverse
microenvironments.
A
pressing
challenge
is
to
effectively
enhance
the
regenerative
microenvironment
at
different
stages
healing
process,
tailoring
interventions
as
needed.
Here,
a
dual
enzyme
mimetic
and
bacterial
responsive
self‐activating
antimicrobial
hydrogel
designed
IPUs
introduced.
This
incorporates
pH‐responsive
enzyme‐active
nanoplatforms
(HNTs‐Fe‐Ag)
encapsulated
within
methacrylate‐modified
silk
fibroin
(SFMA)
dopamine
methacrylamide
(DMA)
matrix.
composite
exhibits
adaptive
regulation
capabilities.
Under
low
pH
infection,
it
has
excellent
activity
by
•OH
generation
in
conjunction
with
photothermal
effects.
neutral
alkaline
chronic
inflammation,
catalyzes
decomposition
hydrogen
peroxide
(H
2
O
)
produce
oxygen
(O
),
thereby
alleviating
hypoxia
scavenging
reactive
species
(ROS),
which
turn
remodulates
phenotype
macrophages.
demonstrates
on‐demand
therapeutic
effects
wounds,
significantly
enhancing
IUPs
promoting
wound
closure,
inflammation
regulation,
collagen
deposition
through
self‐activated
action
during
infection
relief
recovery.
approach
offers
novel
strategy
for
developing
smart
dressings.
