Functional hydrogels for accelerated wound healing: advances in conductive hydrogels and self-powered electrical stimulation
Journal of Biomaterials Science Polymer Edition,
Год журнала:
2025,
Номер
unknown, С. 1 - 32
Опубликована: Апрель 14, 2025
Compared
to
traditional
dressings,
hydrogel
dressings
not
only
protect
the
wound
surface
and
prevent
bacterial
infection
but
also
possess
excellent
moisturizing
properties,
which
can
provide
an
optimal
moist
environment
for
healing,
exhibit
good
biocompatibility,
making
them
considered
best
treatment
materials.
This
review
focuses
on
research
status
application
progress
of
various
functional
such
as
hemostatic,
antimicrobial,
anti-inflammatory,
antioxidant,
conductive
hydrogels.
It
proposes
combination
hydrogels
with
flexible
solar
cells
form
self-powered
devices.
externally
powered
devices,
this
approach
reduce
carbon
footprints
by
utilizing
clean
energy,
aligning
neutrality
policy
requirements.
Additionally,
it
eliminates
need
frequent
battery
replacement
or
power
connections,
effectively
saving
labor
operational
costs.
Self-powered
devices
convert
energy
into
electrical
is
conducted
site
through
hydrogels,
generating
continuous
stimulation
(ES).
guides
directional
migration
keratinocytes
fibroblasts
toward
center
wound;
activates
MAPK/ERK
signaling
pathway
accelerate
cell
cycle
process,
upregulates
expression
vascular
endothelial
growth
factor,
thereby
inducing
proliferation
lumen
formation.
These
multiple
mechanisms
work
synergistically
promote
healing.
Finally,
provides
outlook
emergence
applications
multifunctional
stimuli-responsive
highlighting
common
challenges
in
future
development
weak
mechanical
strength
poor
long-term
stability,
well
feasible
solutions
these
issues.
Язык: Английский
Smart macrophage-targeting wound dressings accelerate diabetic wound healing
Chemical Engineering Journal,
Год журнала:
2024,
Номер
unknown, С. 156860 - 156860
Опубликована: Окт. 1, 2024
Язык: Английский
Imaging Identifies Superior Inflammation Targeting of M1 Macrophages for Cryo‐Shocked Cell Pulmonary Drug Delivery to Treat Acute Lung Injury
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(30)
Опубликована: Авг. 24, 2024
In
the
realm
of
combating
acute
lung
injury
(ALI)
induced
by
a
myriad
triggers
including
sepsis,
pneumonia,
aspiration,
trauma,
and
pancreatitis,
macrophages
emerge
as
crucial
players.
However,
traditional
treatments
such
systemic
administration
glucocorticoids
come
with
baggage
severe
side
effects,
curtailing
their
utility.
Enter
an
innovative
solution:
biomimetic
drug
delivery
system
fashioned
from
cryo-shocked
macrophages,
tailored
for
pulmonary
delivery.
Positron
emission
tomography
(PET)
imaging
has
shed
light
on
remarkable
targeting
abilities
live
M1
showcasing
unparalleled
efficacy
in
homing
local
inflammatory
foci
when
contrasted
naive,
M1,
M2
macrophages.
Building
upon
this
foundation,
liquid
nitrogen-treated
(LNT)
are
developed,
engineered
to
preserve
inflammation-targeting
prowess
while
sidestepping
release
pro-inflammatory
cytokines.
This
breakthrough
allows
directly
inflamed
tissues,
efficiently
quelling
inflammation
mitigating
edema
drastically
reducing
exposure.
Inspired
effectiveness
potential
glucocorticoid-loaded
LNT
harnessed,
utilizing
them
stealthy
"Trojan
horse"
battle
against
pneumonia-induced
ALI.
approach
holds
promise
safe
potent
treatment
avenue
injury.
Язык: Английский
Polydatin and chitosan-silver co-loaded nanocomplexes for synergistic treatment of rheumatoid arthritis via repolarizing macrophages and inducing apoptosis of fibroblast-like synoviocytes
Materials & Design,
Год журнала:
2024,
Номер
245, С. 113287 - 113287
Опубликована: Авг. 30, 2024
Язык: Английский
Recent advances in the medical applications of two-dimensional MXene nanosheets
Nanomedicine,
Год журнала:
2024,
Номер
unknown, С. 1 - 22
Опубликована: Ноя. 18, 2024
MXene-based
materials
are
gaining
significant
attention
due
to
their
exceptional
properties
and
adaptability,
leading
diverse
advanced
applications.
In
3D
printing,
MXenes
enhance
the
performance
of
photoblockers,
photocurable
inks,
composites,
enabling
creation
precise,
flexible
durable
structures.
MXene/siloxane
composites
offer
both
flexibility
resilience,
while
MXene/spidroin
scaffolds
provide
excellent
biocompatibility
mechanical
strength,
making
them
ideal
for
tissue
engineering.
Sustainable
inks
such
as
MXene/cellulose
nano
alginate/MXene
MXene/emulsion
underscore
role
in
high-performance
printed
materials.
cancer
therapy,
enable
innovative
photothermal
photodynamic
therapies,
where
nanosheets
generate
heat
reactive
oxygen
species
destroy
cells.
MXene
theranostic
nanoprobes
combine
imaging
treatment,
MXene/niobium
support
hyperthermia
therapy
hydrogels
allow
controlled
drug
release.
Additionally,
nanozymes
catalytic
activity,
MXene/gold
nanorods
near-infrared-triggered
release
noninvasive
treatments.
antimicrobial
applications,
material
durability
hygiene,
providing
anticorrosive
protection
metals.
For
instance,
MXene/graphene,
MXene/polycaprolactone
nanofibers
MXene/chitosan
exhibit
antibacterial
activity.
sensors
have
been
developed
detect
antibiotic
residues.
cryogels
also
promote
regeneration,
nanohybrids
facilitate
photocatalytic
therapy.
These
advancements
potential
regenerative
medicine
other
fields.
Язык: Английский
Synergic effects of core-shell nanospheres and magnetic field for sciatic nerve regeneration in decellularized artery conduits with Schwann cells
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Дек. 19, 2024
Numerous
conduits
have
been
developed
to
improve
peripheral
nerve
regeneration.
However,
challenges
remain,
including
remote
control
of
conduit
function,
and
programmed
cell
behaviors
like
orientation.
We
synthesized
Fe3O4-MnO2@Zirconium-based
Metal-organic
frameworks@Retinoic
acid
(FMZMR)
core-shell
assessed
their
impact
on
Schwann
function
behavior
within
made
from
decellularized
human
umbilical
arteries
(DHUCA)
under
magnetic
field
(MF).
FMZMR
core-shell,
featuring
a
spherical
porous
structure
catalytic
properties,
effectively
scavenges
radicals
facilitates
controlled
drug
release
MF.
The
histology
the
DHUCA
indicates
effective
decellularization
with
adequate
tensile
strength
Young's
modulus
for
sciatic
In-vitro
results
demonstrate
that
is
biocompatible
promotes
proliferation
through
remotely
release.
Furthermore,
its
synergy
MF
enhances
orientation
increases
neurite
length
by
~
1.93-fold.
Functional
histological
evaluations
indicate
combined
regeneration,
decreases
muscle
atrophy,
new
neuron
growth
myelin
formation,
without
negatively
affecting
vital
tissues.
This
study
suggests
synergistic
effect
can
alleviate
some
treatment
challenges.
Язык: Английский
3D Printed Multifunctional Bioadhesive Patch with Intrinsic Bioelectronic Properties for Decoding Electromechanical and Anisotropic Cardiac Microenvironment
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 6, 2024
ABSTRACT
Fabricating
anisotropic
multifunctional
bioadhesive
patches
with
tunable
mechanical
stiffness,
electrical
conductivity,
antimicrobial
activity,
and
modulating
cellular
behavior
is
crucial
for
the
successful
management
of
cardiac
tissue
injury
boosting
immunogenic
microenvironments.
Direct
ink
writing
(DIW)-based
3D
printing
holds
tremendous
potential
developing
electroactive
(ECPs)
microarchitecture.
Inspired
by
native
myocardium,
we
developed
a
ECP
stiffness
incorporating
highly
conductive
graphene
oxide/nanodiamond
(GO@ND)
complex
into
biocompatible
carboxymethyl
chitosan/polyvinyl
alcohol
(CSA)
matrix
regulating
cardiomyogenic
cues.
The
incorporation
GO@ND
enhanced
conductivity
(∼22.6
S
mm
-1
)
high
interfacial
toughness
(>250
MJ
m
improved
printability
(
n
=
0.5)
concentration-dependent
self-assembly
CSA
matrix.
We
observed
that
stimulation
(EFs;
250
mV/20
min/day)
through
nanoengineered
resulted
in
broad-spectrum
antibacterial
activity
against
E.
coli
S.
aureus
99.29%
98.74%,
respectively,
via
sustained
release
curcumin
(Cur).
Moreover,
electromechanical
study
revealed
higher
(∼6.2
kPa)
activated
cytoplasmic
YAPs
during
macrophage
polarization.
Besides,
EFs
regulated
human
cardiomyocyte
differentiation
force-driven
early
activation
Vinculin,
triggering
phosphorylation
NFATc3
activating
Lamin
A/C
YAP-dependent
manner.
Based
on
these
findings,
anticipated
fabricated
patch
had
electro-cardiomyogenic
microenvironment
abilities.
Язык: Английский
Immunomechanobiology: Engineering the Activation and Function of Immune Cells with the Mechanical Signal of Fluid Shear Stress
IEEE Reviews in Biomedical Engineering,
Год журнала:
2024,
Номер
18, С. 231 - 249
Опубликована: Ноя. 22, 2024
Immunomechanobiology,
the
study
of
how
physical
forces
influence
behavior
and
function
immune
cells,
is
a
rapidly
growing
area
research.
It
becoming
increasingly
recognized
that
mechanical
stimuli,
such
as
fluid
shear
forces,
are
critical
determinant
cell
regulation.
In
this
review,
we
discuss
principles
significance
various
present
within
human
body,
with
focus
on
flow
its
impact
activation
function.
Moreover,
engineering
approaches
used
to
mechanobiology,
their
implications
in
health
diseases
cancer,
autoimmune
disorders,
infectious
disease.
Язык: Английский