Chemistry of Materials, Год журнала: 2024, Номер unknown
Опубликована: Дек. 27, 2024
Язык: Английский
Materials Today Bio, Год журнала: 2024, Номер 29, С. 101315 - 101315
Опубликована: Окт. 31, 2024
Язык: Английский
Процитировано
5
Опубликована: Янв. 1, 2025
The discharge of silk sericin (SS) as waste with wastewater presents a dual challenge in terms resource utilization and environmental protection. In this study, SS was extracted from silkworm cocoons, multifunctional hydrogel tetrakis (hydroxymethyl) phosphonium sulfate antibacterial antioxidant components developed cross-linked polyvinyl alcohol agarose (PATS) to provide mechanical properties accelerate wound healing. PATS demonstrated excellent tensile compressive properties. Furthermore, exhibited notable capabilities against Escherichia coli Staphylococcus aureus, significantly scavenged the production free radicals. Additionally, displayed favorable cytocompatibility hemocompatibility. Ultimately, effectively accelerated healing rat full-thickness skin defect model. Therefore, study provides theoretical basis for development dressings highlights potential application sustainable biomaterials.
Язык: Английский
Процитировано
0
The FASEB Journal, Год журнала: 2025, Номер 39(1)
Опубликована: Янв. 9, 2025
Abstract Wounds in patients with diabetes present significant physical and economic challenges due to impaired healing prolonged inflammation, exacerbated by complex interactions between microbes. Especially, the development of diabetic foot ulcers (DFUs) remain an urgent clinical problem. The human gut harbors a vast microbial ecosystem comprising intestinal flora their metabolic products. Recent advancements research have illuminated concept “gut‐skin axis,” revealing intricate relationships microbiota, microbiota‐derived metabolites, various skin diseases, including DFUs. This review aims unravel formation process DFUs context gut‐skin axis. We reviewed current progress worldwide regarding axis, compared discussed changes microbiota colonizing roles metabolites such as lipopolysaccharides, short‐chain fatty acids, trimethylamine‐N‐oxide are highlighted. also treatment strategies currently employed practice identified potential therapeutic targets probiotics for treating need more comprehensive experimental designs elucidate relationship its therefore
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 296, С. 139809 - 139809
Опубликована: Янв. 11, 2025
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 139916 - 139916
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Biomaterials Advances, Год журнала: 2025, Номер unknown, С. 214216 - 214216
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 1 - 16
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
0
Advanced Materials Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Март 2, 2025
Abstract Radiation combined wound injury (RCWI) presents significant healing challenges due to radiation‐induced immune suppression, organ dysfunction, and disruption of growth factors extracellular matrix dynamics. Conventional dressings like gauze are inadequate for these complex injuries. Hydrogels have emerged as a promising solution skin mucosal injuries, offering superior mechanical strength, cell‐regeneration support, multifunctional biochemical properties, including antimicrobial, antioxidant, adhesive capabilities. They create moist, biocompatible environment that promotes cell proliferation, migration, tissue repair, while enabling sustained drug delivery, free radical scavenging, inflammation Deoxyribonucleic acid (DNA） repair. Despite their potential, systematic comparison radiation injuries remains lacking. This review addresses this gap by focusing on hydrogels supportive matrices therapeutic enhancers, exploring radiation‐impaired mechanisms, highlighting hydrogel advancements, comparing efficacy in common versus wounds. It also provides future research directions clinical practice insights, emphasizing the potential RCWI treatment. By bridging current knowledge gaps, aims guide improve practices radiology trauma medicine.
Язык: Английский
Процитировано
0
Biomacromolecules, Год журнала: 2025, Номер unknown
Опубликована: Март 18, 2025
Bioactive hydrogels are garnering increasing interest in wound management due to their porous structural features and versatile intrinsic biological activities. Importantly, the antibacterial capacity is a crucial requirement for hydrogel dressings chronically infected wounds. In this study, we report an constructed from silk sericin (SS) cross-linked with glycyrrhizic acid (GA) integrated silver ions (Ag+) accelerate healing of bacterial-infected The resultant sericin-glycyrrhizic acid-Ag+ (SGA) demonstrates favorable mechanical properties, effectively preventing secondary injury Moreover, vitro studies indicated that SGA possesses excellent swelling ratios, degradability, cytocompatibility, promoting cell growth proliferation. Notably, exhibited effective activity against both Gram-positive Gram-negative bacteria through release Ag+. Staphylococcus aureus-infected model, efficiently eradicated bacteria, thus repair. Overall, our work establishes novel strategy developing multifunctional based on natural materials managing bacteria-infected
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Март 18, 2025
Язык: Английский
Процитировано
0