ACS Materials Au,
Год журнала:
2024,
Номер
5(1), С. 115 - 140
Опубликована: Ноя. 28, 2024
The
delivery
of
molecules,
such
as
DNA,
RNA,
peptides,
and
certain
hydrophilic
drugs,
across
the
epidermal
barrier
poses
a
significant
obstacle.
Microneedle
technology
has
emerged
prominent
area
focus
in
biomedical
research
because
its
ability
to
deliver
wide
range
biomolecules,
vaccines,
medicines,
other
substances
through
skin.
Microneedles
(MNs)
form
microchannels
by
disrupting
skin's
structure,
which
compromises
function,
facilitating
easy
penetration
drugs
into
These
devices
enhance
administration
many
therapeutic
skin,
enhancing
their
stability.
Transcutaneous
medications
using
microneedle
patch
offers
advantages
over
conventional
drug
methods.
containing
active
can
be
stimulated
different
internal
external
factors
result
regulated
release
substances.
To
achieve
efficient
desired
location,
it
is
necessary
consider
design
needles
with
appropriate
optimized
characteristics.
choice
materials
for
developing
manufacturing
these
vital
determining
pharmacodynamics
pharmacokinetics
delivery.
This
article
provides
most
recent
update
overview
numerous
systems
that
utilize
activators
stimulate
components
from
microneedles.
Further,
discusses
utilized
producing
microneedles
strategies
important
managing
drugs.
An
explanation
commonly
employed
fabrication
techniques
applications
electronics,
particularly
integrated
systems,
discussed.
successfully
implement
clinical
settings,
essential
comprehensively
assess
several
factors,
biocompatibility,
stability,
safety,
production
cost.
Finally,
an
in-depth
review
criteria
difficulties
potential
future
direction
delivering
monitoring
diseases
explored.
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 390 - 390
Опубликована: Март 19, 2025
Three-dimensional
printing
technology
is
transforming
pharmaceutical
manufacturing
by
shifting
from
conventional
mass
production
to
additive
manufacturing,
with
a
strong
emphasis
on
personalized
medicine.
The
integration
of
bioinks
and
AI-driven
optimization
further
enhancing
this
innovation,
enabling
drug
precise
dosages,
tailored
drug-release
profiles,
unique
multi-drug
combinations
that
respond
individual
patient
needs.
This
advancement
significantly
impacting
healthcare
accelerating
development,
encouraging
innovative
designs,
treatment
efficacy.
Traditional
follows
one-size-fits-all
approach,
which
often
fails
meet
the
specific
requirements
patients
medical
conditions.
In
contrast,
3D
printing,
coupled
bioink
formulations,
allows
for
on-demand
production,
reducing
dependency
large-scale
storage.
AI-powered
design
process
refine
dosage
forms,
printability,
release
mechanisms,
ensuring
precision
efficiency
in
manufacturing.
These
advancements
have
potential
lower
overall
costs
while
improving
adherence
medication
regimens.
review
explores
potential,
challenges,
environmental
benefits
positioning
it
as
key
driver
next-generation
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 26, 2025
Abstract
Driven
by
the
growing
burden
of
chronic
diseases
and
limited
public
healthcare
resources,
portable
health
monitoring
platforms
are
widely
developed
to
enable
continuous
timely
dissemination
provide
users
with
management
disease
prevention.
However,
it
is
still
a
challenge
for
precision
fully
bio‐integrated
electronic
devices
achieve
stable
physiological
signal
recording
over
long
periods
time.
Recently,
semi‐implantable
bioelectronics
(SI‐bioelectronics)
have
excelled
in
real‐time,
long‐term,
high‐sensitivity
pathological
signals
minimal
invasiveness,
enabled
precise
microneedle
sensing
probes.
In
this
review,
comprehensive
overview
recent
advancements
SI‐bioelectronics
provided,
focus
on
their
structures,
design
considerations,
performances
biochemical
indicators,
bioelectrical
signals,
biomechanical
signals.
Opportunities
research
such
as
smart
medicine
Internet
Things
also
discussed,
which
will
drive
toward
intelligence
efficiency.
Expert Opinion on Drug Delivery,
Год журнала:
2024,
Номер
21(7), С. 1053 - 1068
Опубликована: Июль 2, 2024
Introduction
Microneedles
(MNs)
are
miniaturized,
painless,
and
minimally
invasive
platforms
that
have
attracted
significant
attention
over
recent
decades
across
multiple
fields,
such
as
drug
delivery,
disease
monitoring,
diagnosis,
cosmetics.
Several
manufacturing
methods
been
employed
to
create
MNs;
however,
these
approaches
come
with
drawbacks
related
complicated,
costly,
time-consuming
fabrication
processes.
In
this
context,
employing
additive
(AM)
technology
for
MN
allows
the
quick
production
of
intricate
prototypes
exceptional
precision,
providing
flexibility
customize
MNs
according
desired
shape
dimensions.
Furthermore,
AM
demonstrates
promise
in
sophisticated
transdermal
delivery
systems
medical
devices
through
integration
various
technologies.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Март 7, 2025
Diabetes
is
a
widespread
metabolic
disorder
that
presents
considerable
challenges
in
its
management.
Recent
advancements
biomaterial
research
have
shed
light
on
innovative
approaches
for
the
treatment
of
diabetes.
This
review
examines
role
biomaterials
diabetes
diagnosis
and
treatment,
as
well
their
application
managing
diabetic
wounds.
By
evaluating
recent
developments
alongside
future
obstacles,
highlights
promising
potential
care,
underscoring
importance
enhancing
patient
outcomes
refining
methodologies.
