Bioengineering,
Год журнала:
2025,
Номер
12(6), С. 579 - 579
Опубликована: Май 28, 2025
Flexoelectricity
arises
in
materials
under
strain
gradients,
which
can
be
particularly
significant
for
situations
the
existence
of
other
electromechanical
properties
is
absent
or
generating
large
flexoelectric
achievable.
This
effect
has
also
been
observed
some
biological
materials,
whose
understanding
hugely
help
to
further
enhance
our
vital
processes
like
mechanotransduction,
as
well
development
applications
regenerative
medicine
and
drug
delivery.
While
field
flexoelectricity
a
relevant
topic
relatively
new
still
developing,
current
study
aims
review
available
results
on
effects
such
cells
cell
membranes,
hearing
mechanisms,
bone,
their
potential
biomedical
research.
Therefore,
we
first
provide
brief
background
two
main
couplings
(piezoelectricity
flexoelectricity)
further,
how
experimentally
theoretically
identified.
We
then
different
aim
study.
Within
that,
additional
emphasis
influence
this
bone
remodeling.
In
particular,
outlines
limitations
provides
directions
future
work,
emphasizing
crucial
role
next-generation
devices
optimizing
function
area
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(9), С. 4242 - 4242
Опубликована: Апрель 29, 2025
Bone
defects
caused
by
various
traumas
and
diseases
such
as
osteoporosis,
which
affects
bone
density,
osteosarcoma,
the
integrity
of
structure,
are
now
well
known.
Given
this
situation,
several
innovative
research
projects
have
been
reported
to
improve
orthopedic
methods
technologies
that
positively
contribute
regeneration
affected
tissue,
representing
a
significant
advance
in
regenerative
medicine.
This
review
article
comprehensively
analyzes
transition
from
existing
for
implants
tissue
biomaterials.
These
biomaterials
great
interest
last
decade
due
their
physicochemical
characteristics,
allow
them
overcome
most
common
limitations
traditional
grafting
methods,
availability
risk
rejection
after
application
could
be
achieved
through
an
exhaustive
study
applications
properties
materials
with
potential
medicine,
using
magnetic
nanoparticles
hydrogels
sensitive
external
stimuli,
including
pH
temperature.
In
regard,
describes
relevant
compounds
used
regeneration,
promoting
integration
these
area's
thereby
allowing
preventing
amputation.
Additionally,
types
interactions
between
mesenchymal
stem
cells
effects
on
discussed,
is
critical
developing
optimal
properties.
Furthermore,
mechanisms
action
enhance
osteoconduction
osteoinduction,
ensuring
success
therapies,
analyzed.
enables
treatment
tailored
each
patient's
condition,
avoiding
limb
Consequently,
promising
future
medicine
emerging,
therapies
revolutionize
management
defects,
offering
more
efficient
safer
solutions.
Macromolecular Rapid Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 26, 2025
Abstract
Extracellular
matrix
(ECM)
is
a
multifaceted
network
that
encases
cells,
composed
of
various
polysaccharides,
proteins,
and
adhesion
molecules,
etc.
It
plays
critical
role
in
providing
structural
support
to
cells
regulating
essential
cellular
activities
such
as
proliferation,
migration,
differentiation.
Due
these
functions,
decellularized
extracellular
(dECM)
has
attracted
considerable
interest
biomedicine
holds
promising
application
potential.
However,
simple
dECM
materials
are
often
insufficient
meet
the
diverse
demands
different
physiological
or
pathological
microenvironments.
Recently,
composite
made
from
biomaterials
have
emerged
solution,
significantly
enhancing
biological
functions
clinical
applicability
dECM.
By
using
material
preparation
techniques,
can
be
endowed
with
specific
properties,
enabling
them
better
requirements
biomedical
applications.
In
this
review,
techniques
for
dECM‐based
biomaterials,
including
physical
crosslinking,
chemical
modification,
3D
printing,
electrospinning,
summarized.
Different
types
composites
also
classified,
their
properties
discussed,
highlighting
suitability
This
review
aims
provide
comprehensive
reference
development
translation
application.
Bioengineering,
Год журнала:
2025,
Номер
12(6), С. 579 - 579
Опубликована: Май 28, 2025
Flexoelectricity
arises
in
materials
under
strain
gradients,
which
can
be
particularly
significant
for
situations
the
existence
of
other
electromechanical
properties
is
absent
or
generating
large
flexoelectric
achievable.
This
effect
has
also
been
observed
some
biological
materials,
whose
understanding
hugely
help
to
further
enhance
our
vital
processes
like
mechanotransduction,
as
well
development
applications
regenerative
medicine
and
drug
delivery.
While
field
flexoelectricity
a
relevant
topic
relatively
new
still
developing,
current
study
aims
review
available
results
on
effects
such
cells
cell
membranes,
hearing
mechanisms,
bone,
their
potential
biomedical
research.
Therefore,
we
first
provide
brief
background
two
main
couplings
(piezoelectricity
flexoelectricity)
further,
how
experimentally
theoretically
identified.
We
then
different
aim
study.
Within
that,
additional
emphasis
influence
this
bone
remodeling.
In
particular,
outlines
limitations
provides
directions
future
work,
emphasizing
crucial
role
next-generation
devices
optimizing
function
area
