Flexoelectricity in Biological Materials and Its Potential Applications in Biomedical Research DOI Creative Commons
Melika Mohammadkhah, Vukašin Slavković, Sandra Klinge

и другие.

Bioengineering, Год журнала: 2025, Номер 12(6), С. 579 - 579

Опубликована: Май 28, 2025

Flexoelectricity arises in materials under strain gradients, which can be particularly significant for situations the existence of other electromechanical properties is absent or generating large flexoelectric achievable. This effect has also been observed some biological materials, whose understanding hugely help to further enhance our vital processes like mechanotransduction, as well development applications regenerative medicine and drug delivery. While field flexoelectricity a relevant topic relatively new still developing, current study aims review available results on effects such cells cell membranes, hearing mechanisms, bone, their potential biomedical research. Therefore, we first provide brief background two main couplings (piezoelectricity flexoelectricity) further, how experimentally theoretically identified. We then different aim study. Within that, additional emphasis influence this bone remodeling. In particular, outlines limitations provides directions future work, emphasizing crucial role next-generation devices optimizing function area

Язык: Английский

Evolution in Bone Tissue Regeneration: From Grafts to Innovative Biomaterials DOI Open Access
Domingo César Carrascal-Hernández, Juan Pablo Martínez-Cano, Juan David Rodríguez Macías

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(9), С. 4242 - 4242

Опубликована: Апрель 29, 2025

Bone defects caused by various traumas and diseases such as osteoporosis, which affects bone density, osteosarcoma, the integrity of structure, are now well known. Given this situation, several innovative research projects have been reported to improve orthopedic methods technologies that positively contribute regeneration affected tissue, representing a significant advance in regenerative medicine. This review article comprehensively analyzes transition from existing for implants tissue biomaterials. These biomaterials great interest last decade due their physicochemical characteristics, allow them overcome most common limitations traditional grafting methods, availability risk rejection after application could be achieved through an exhaustive study applications properties materials with potential medicine, using magnetic nanoparticles hydrogels sensitive external stimuli, including pH temperature. In regard, describes relevant compounds used regeneration, promoting integration these area's thereby allowing preventing amputation. Additionally, types interactions between mesenchymal stem cells effects on discussed, is critical developing optimal properties. Furthermore, mechanisms action enhance osteoconduction osteoinduction, ensuring success therapies, analyzed. enables treatment tailored each patient's condition, avoiding limb Consequently, promising future medicine emerging, therapies revolutionize management defects, offering more efficient safer solutions.

Язык: Английский

Процитировано

0

Nanomaterials in Regenerative Medicine: Advancing the Future of Tissue Engineering DOI
Ravikumar Jayabal

Regenerative Engineering and Translational Medicine, Год журнала: 2025, Номер unknown

Опубликована: Май 6, 2025

Язык: Английский

Процитировано

0

Nature‐Inspired Macromolecular Biocomposites Based on Decellularized Extracellular Matrix DOI
Yi‐Han Lin, Yu-Ting Lin, Haili Hu

и другие.

Macromolecular Rapid Communications, Год журнала: 2025, Номер unknown

Опубликована: Май 26, 2025

Abstract Extracellular matrix (ECM) is a multifaceted network that encases cells, composed of various polysaccharides, proteins, and adhesion molecules, etc. It plays critical role in providing structural support to cells regulating essential cellular activities such as proliferation, migration, differentiation. Due these functions, decellularized extracellular (dECM) has attracted considerable interest biomedicine holds promising application potential. However, simple dECM materials are often insufficient meet the diverse demands different physiological or pathological microenvironments. Recently, composite made from biomaterials have emerged solution, significantly enhancing biological functions clinical applicability dECM. By using material preparation techniques, can be endowed with specific properties, enabling them better requirements biomedical applications. In this review, techniques for dECM‐based biomaterials, including physical crosslinking, chemical modification, 3D printing, electrospinning, summarized. Different types composites also classified, their properties discussed, highlighting suitability This review aims provide comprehensive reference development translation application.

Язык: Английский

Процитировано

0

Flexoelectricity in Biological Materials and Its Potential Applications in Biomedical Research DOI Creative Commons
Melika Mohammadkhah, Vukašin Slavković, Sandra Klinge

и другие.

Bioengineering, Год журнала: 2025, Номер 12(6), С. 579 - 579

Опубликована: Май 28, 2025

Flexoelectricity arises in materials under strain gradients, which can be particularly significant for situations the existence of other electromechanical properties is absent or generating large flexoelectric achievable. This effect has also been observed some biological materials, whose understanding hugely help to further enhance our vital processes like mechanotransduction, as well development applications regenerative medicine and drug delivery. While field flexoelectricity a relevant topic relatively new still developing, current study aims review available results on effects such cells cell membranes, hearing mechanisms, bone, their potential biomedical research. Therefore, we first provide brief background two main couplings (piezoelectricity flexoelectricity) further, how experimentally theoretically identified. We then different aim study. Within that, additional emphasis influence this bone remodeling. In particular, outlines limitations provides directions future work, emphasizing crucial role next-generation devices optimizing function area

Язык: Английский

Процитировано

0