Progress in Nanotechnology for Treating Ocular Surface Chemical Injuries: Reflecting on Advances in Ophthalmology
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 4, 2025
Ocular
surface
chemical
injuries
often
result
in
permanent
visual
impairment
and
necessitate
complex,
long-term
treatments.
Immediate
extensive
irrigation
serves
as
the
first-line
intervention,
followed
by
various
therapeutic
protocols
applied
throughout
different
stages
of
condition.
To
optimize
outcomes,
conventional
regimens
increasingly
incorporate
biological
agents
surgical
techniques.
In
recent
years,
nanotechnology
has
made
significant
strides,
revolutionizing
management
ocular
enabling
sustained
drug
release,
enhancing
treatment
efficacy,
minimizing
side
effects.
This
review
provides
a
comprehensive
analysis
etiology,
epidemiology,
classification,
therapies
for
burns,
with
special
focus
on
nanotechnology-based
delivery
systems
managing
injuries.
Twelve
categories
nanocarrier
platforms
are
examined,
including
liposomes,
nanoemulsions,
nanomicelles,
nanowafers,
nanostructured
lipid
carriers,
nanoparticles,
hydrogels,
dendrimers,
nanocomplexes,
nanofibers,
nanozymes,
nanocomposite
materials,
highlighting
their
advantages
targeted
delivery,
biocompatibility,
improved
healing
efficacy.
Additionally,
current
challenges
limitations
field
discussed
future
potential
treating
diseases
is
explored.
presents
most
examination
this
topic
to
date,
aiming
link
advancements
broader
strategies.
Язык: Английский
Molecularly Imprinted Nanozymes with Substrate Specificity: Current Strategies and Future Direction
Small,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
Abstract
Molecular
imprinting
technology
(MIT)
stands
out
for
its
exceptional
simplicity
and
customization
capabilities
has
been
widely
employed
in
creating
artificial
antibodies
that
can
precisely
recognize
efficiently
capture
target
molecules.
Concurrently,
nanozymes
have
emerged
as
promising
enzyme
mimics
the
biomedical
field,
characterized
by
their
remarkable
stability,
ease
of
production
scalability,
robust
catalytic
activity,
high
tunability.
Drawing
inspiration
from
natural
enzymes,
molecularly
imprinted
combine
unique
benefits
both
MIT
nanozymes,
thereby
conferring
biomimetic
catalysts
with
substrate
specificity
selectivity.
In
this
review,
latest
strategies
fabrication
focusing
on
use
organic
polymers
inorganic
nanomaterials
are
explored.
Additionally,
cutting‐edge
techniques
generating
atom‐layer‐imprinted
islands
ultra‐thin
atomic‐scale
thickness
is
summarized.
Their
applications
particularly
noteworthy
fields
catalyst
optimization,
detection
techniques,
therapeutic
strategies,
where
they
boost
reaction
selectivity
efficiency,
enable
precise
identification
quantification
substances,
enhance
effectiveness
while
minimizing
adverse
effects.
Lastly,
prevailing
challenges
field
delineate
potential
avenues
future
progress
encapsulated.
This
review
will
foster
advancements
expand
applications.
Язык: Английский
Maltodextrin-driven MOF Nano-antibacterial system for effective targeted bacteria and enhancing photodynamic therapy in bacterial keratitis
Journal of Controlled Release,
Год журнала:
2025,
Номер
380, С. 1164 - 1183
Опубликована: Фев. 27, 2025
Язык: Английский
High-Performance Biosensing Platforms Based on Enzyme-Linked Nucleic Acid Amplification Regulated by Synergistic Allosteric Hairpin Catalysis of Bimetallic Nanozymes and Its Mechanisms
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 7, 2025
Sugar
cane
smut
disease
can
greatly
decrease
both
the
production
and
quality
of
sugar
cane,
its
early
diagnosis
is
an
effective
strategy
to
ensure
increase
income
cane.
Therefore,
developing
high-precision
detection
methods
has
major
implications
for
actual
Herein,
we
synthesize
bimetallic
nanozymes
Fe3O4@AuNPs
with
excellent
glucose
oxidase-like
activity
nitrogen-doped
graphdiyne
(N-GDY)
conductivity
interfacial
loading
capacity,
which
are
used
as
catalysts
biofuel
cells
flexible
electrode
substrates,
respectively.
An
allosteric
hairpin-regulated
enzymatic
cascade
nucleic
acid
amplification
employed
construct
a
novel
biosensing
platform
precise
highly
sensitive
analysis
pathogen
causing
disease,
catalytic
mechanism
studied.
The
specifically
cause
complementary
region
hairpin
migrate
form
new
functional
hairpin.
Under
promotion
enzymes,
dual
occurs
using
template
outputs
large
amount
double-stranded
products,
captured
by
RCA
long
chain
on
biocathode.
At
cathode,
DNA
double
strands
capable
holding
quantity
Ru[(NH3)6]3+
through
electrostatic
attraction.
anode
catalyze
oxidation
produce
electrons,
AuNPs/N-GDY
efficiently
transfer
electrons
cathode
obtain
strong
open-circuit
voltage
signal,
exhibits
linear
correlation
in
range
0.0001-10000
pM,
limit
53.29
aM
(S/N
=
3).
sensing
offers
reliable
method
that
allows
accurate
great
application
development
potential
identification
on-site
rapid
detection.
Язык: Английский
Ocular drug delivery systems based on nanotechnology: a comprehensive review for the treatment of eye diseases
Discover Nano,
Год журнала:
2025,
Номер
20(1)
Опубликована: Май 3, 2025
Ocular
drug
delivery
is
a
significant
challenge
due
to
the
intricate
anatomy
of
eye
and
various
physiological
barriers.
Conventional
therapeutic
approaches,
while
effective
some
extent,
often
fall
short
in
effectively
targeting
ocular
diseases,
resulting
suboptimal
outcomes
factors
such
as
poor
bioavailability,
frequent
dosing
requirements,
systemic
side
effects,
limited
penetration
through
This
review
elucidates
eye's
physiology,
prevalent
traditional
modalities,
inherent
pharmacokinetic
pharmacodynamic
limitations
associated
with
these
modalities.
Subsequently,
it
delves
into
nanotechnology-based
solutions,
presenting
breakthroughs
nanoformulations
nanocrystals,
liposomes,
dendrimers,
nanoemulsions
that
have
demonstrated
enhanced
stability,
controlled
release,
deeper
penetration.
Additionally,
explores
range
nanosized
carriers,
including
nano-structured
lipid
hydrogels,
nanogels,
nanoenzymes,
microparticles,
conjugates,
exosomes,
nanosuspensions,
viral
vectors,
polymeric
nanoparticles,
their
applications.
Unique
insights
include
emerging
innovations
nanowafers
transcorneal
iontophoresis,
which
indicate
paradigm
shifts
non-invasive
delivery.
Furthermore,
sheds
light
on
advantages
platforms
addressing
challenges
Though
nano-based
systems
are
drawing
increasing
attention
potential
enhance
bioavailability
efficacy,
ends
up
emphasizing
imperative
need
for
further
research
drive
innovation
improve
patient
ophthalmology.
Язык: Английский
The Role of Reactive Oxygen Species in Age-Related Macular Degeneration: A Comprehensive Review of Antioxidant Therapies
Biomedicines,
Год журнала:
2024,
Номер
12(7), С. 1579 - 1579
Опубликована: Июль 16, 2024
This
review
article
delves
into
the
intricate
roles
of
reactive
oxygen
species
(ROS)
in
pathogenesis
age-related
macular
degeneration
(AMD).
It
presents
a
detailed
analysis
oxidative
stress
mechanisms
that
contribute
to
development
and
progression
these
diseases.
The
systematically
explores
dual
nature
ROS
ocular
physiology
pathology,
underscoring
their
essential
cellular
signaling
detrimental
effects
when
excess.
In
context
AMD,
focus
is
on
impairment
retinal
pigment
epithelium
Bruch's
membrane,
culminating
deterioration
health.
Central
this
evaluation
various
antioxidant
strategies
prevention
management
AMD.
encompasses
wide
spectrum
antioxidants,
ranging
from
dietary
nutrients
like
vitamins
C
E,
lutein,
zeaxanthin
pharmacological
agents
with
antioxidative
properties.
also
addresses
novel
therapeutic
approaches,
including
gene
therapy
nanotechnology-based
delivery
systems,
aiming
enhance
defense
tissues.
concludes
by
synthesizing
current
research
findings,
clinical
trial
data,
meta-analyses
provide
evidence-based
recommendations.
underscores
need
for
further
optimize
therapies,
considering
individual
patient
factors
disease
stages.
comprehensive
thus
serves
as
valuable
resource
clinicians,
researchers,
healthcare
professionals
ophthalmology,
offering
insights
potential
antioxidants
mitigating
burden
Язык: Английский