The Dawn of a New Pharmaceutical Epoch: Can AI and Robotics Reshape Drug Formulation?
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(29)
Опубликована: Авг. 18, 2024
Abstract
Over
the
last
four
decades,
pharmaceutical
companies’
expenditures
on
research
and
development
have
increased
51‐fold.
During
this
same
time,
clinical
success
rates
for
new
drugs
remained
unchanged
at
about
10
percent,
predominantly
due
to
lack
of
efficacy
and/or
safety
concerns.
This
persistent
problem
underscores
need
innovate
across
entire
drug
process,
particularly
in
formulation,
which
is
often
deprioritized
under‐resourced.
Язык: Английский
Precision‐Guided Stealth Missiles in Biomedicine: Biological Carrier‐Mediated Nanomedicine Hitchhiking Strategy
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 8, 2025
Abstract
Nanodrug
delivery
systems
(NDDS)
have
demonstrated
broad
application
prospects
in
disease
treatment,
prevention,
and
diagnosis
due
to
several
advantages,
including
functionalization
capability,
high
drug‐loading
capacity,
drug
stability
protection,
the
enhanced
permeability
retention
(EPR)
effect.
However,
their
clinical
translation
still
faces
multiple
challenges,
rapid
clearance
by
reticuloendothelial
system
(RES),
poor
targeting
specificity,
insufficient
efficiency
crossing
biological
barriers.
To
address
these
limitations,
researchers
developed
carrier‐mediated
nanomedicine
hitchhiking
strategy
(BCM‐NHS),
which
leverages
circulating
cells,
proteins,
or
bacteria
as
natural
“mobile
carriers”
enhance
delivery.
This
approach
enables
nanocarriers
inherit
intrinsic
properties,
endowing
them
with
immune
evasion,
prolonged
circulation,
dynamic
targeting,
biocompatibility,
biodegradability,
naturally
optimized
interfaces.
Here,
a
systematic
overview
of
BCM‐NHS
is
provided.
First,
review
delves
into
methods
nanoparticles
(NPs)
binding
immobilization,
encompassing
both
surface‐attachment‐mediated
“backpack”
encapsulation‐based
“Trojan
horse”
strategy.
Second,
classification
carriers,
cell‐based
non‐cell‐based
elucidated.
Third,
physical
properties
release
mechanisms
nanomaterials
are
thoroughly
described.
Finally,
latest
applications
therapeutic
diagnostic
contexts
across
various
models
tumor,
ischemic
stroke,
pneumonia
highlighted.
Язык: Английский
The Role of Artificial Intelligence and Machine Learning in Accelerating the Discovery and Development of Nanomedicine
Pharmaceutical Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 2, 2024
Язык: Английский
Pharmaceutical technological trends containing flavonoids: a patent review
Future Medicinal Chemistry,
Год журнала:
2025,
Номер
17(3), С. 363 - 379
Опубликована: Янв. 21, 2025
Flavonoids
such
as
silibinin,
hesperetin,
and
phloretin
exhibit
well-documented
biological
activities,
including
anti-inflammatory,
cytoprotective,
anticarcinogenic,
antioxidant
effects.
However,
their
clinical
application
remains
limited
due
to
challenges
poor
aqueous
solubility,
low
bioavailability,
restricted
intestinal
absorption,
which
can
significantly
reduce
pharmacological
efficacy.
This
review
analyzed
patents
related
innovative
pharmaceutical
technologies
for
flavonoids.
The
analysis
used
databases
from
the
World
Intellectual
Property
Organization
European
Patent
Office.
Following
a
comprehensive
screening
process,
38
were
selected
detailed
examination.
These
highlighted
numerous
studies
on
novel
formulations,
characterizations,
proprietary
conditions.
highlights
technologies,
nanocapsules,
nanoemulsions,
solid
dispersions,
phospholipid
carriers,
inclusion
complexes,
microemulsions,
other
advanced
systems,
enhance
bioactive
molecules'
water
solubility
stability.
Consequently,
these
improve
permeability
absorption
through
intended
administration
route,
demonstrating
potential
of
flavonoids
promising
candidates
various
treatments,
particularly
when
integrated
into
technologies.
Язык: Английский
Mastering the complexities of cancer nanomedicine with text mining, AI and automation
Journal of Controlled Release,
Год журнала:
2025,
Номер
379, С. 906 - 919
Опубликована: Янв. 31, 2025
Язык: Английский
A Novel Paradigm on Data and Knowledge-Driven Drug Formulation Development: Opportunities and Challenges of Machine Learning
Journal of Industrial Information Integration,
Год журнала:
2025,
Номер
unknown, С. 100796 - 100796
Опубликована: Фев. 1, 2025
Язык: Английский
BayBE: a Bayesian Back End for experimental planning in the low-to-no-data regime
Digital Discovery,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
The
Bayesian
Back
End
(BayBE)
has
a
range
of
advanced
features
enabling
scientists
to
go
beyond
the
basic
optimization
loop
and
readily
tackle
real
world
experimental
campaigns.
Язык: Английский
Towards digital transformation: A quality by design approach to plant-based nanostructured lipid carriers formulation
International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
unknown, С. 125797 - 125797
Опубликована: Июнь 1, 2025
This
study
establishes
a
streamlined,
scalable,
and
reproducible
workflow
for
the
sustainable
computationally
guided
development
of
NLCs
by
integrating
Quality
Design
molecular
simulations
with
approaches
in
formulating
plant-based
nanostructured
lipid
carriers
(NLCs)
loaded
curcumin
(CUR)
as
model
natural
molecule.
Our
approach
aims
to
accelerate
screening,
optimization,
processes
nanoformulations
while
maintaining
drug
loading
stability
adhering
green
chemistry
principles.
A
combined-mixture
process
32
Factorial/RSM
experimental
design
were
used.
prepared
using
high-shear
hot
homogenization
at
12,000
RPM
10
min.
Following
characterization,
optimized
evaluated.
Molecular
dynamics
conducted
GROMACS
interaction
between
CUR
NLCs.
The
CUR-NLCs
had
particle
size
(80.28-87.31
nm),
PDI
(0.239-0.276),
Zeta
potential
(-11.63
-14.67
mV),
an
encapsulation
efficiency
(53
%-63
%).
demonstrated
desirable
properties
materials
methods.
Employing
provided
insights
into
assembly
interactions
their
components.
proof-of-concept
successfully
bridged
optimization
advanced
computational
pharmaceutics,
ensuring
that
digital
transformation
sustainability
are
core
future
nanoformulation
research
industrial
adoption.
Язык: Английский